Journal

Perforate St John’s-wort

July 2, 2026 · Omnia Sana
Hypericum perforatum
Family: Hypericaceae  ·  Parts used: Flower, Leaf  ·  Also known as: St John's wort, common St John's wort, perforate St John's wort

Key actions

Anti-inflammatoryAntioxidantAntiviralEmollient / skin-soothingSedative / sleep supportVulnerary (wound healing)

Traditional & clinical uses, by strength of evidence

  • Arthritis / joint painTraditional
  • BruisingTraditional
  • Cold & fluTraditional
  • EczemaTraditional
  • Infection (general)Traditional
  • Inflammation (general)Traditional
  • Insomnia / sleeplessnessTraditional
  • Skin irritationTraditional
  • WoundsTraditional

Selected studies & references

ReviewEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks (2026)
ReviewHypericum perforatum: Traditional uses, clinical trials, and drug interactions (2022)
ReviewClinical relevance of St. John's wort drug interactions revisited (2020)
ReviewClinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis (2017)
ReviewNeuroprotective Activity of Hypericum perforatum and Its Major Components (2016)
ReviewHypericum perforatum L. preparations for menopause: a meta-analysis of efficacy and safety (2013)
ReviewHypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions (2013)
ReviewA review of the antibacterial activity of Hypericum perforatum L. (2010)

All 30 studies in the Knowledge Finder →

Educational use only. This profile summarises traditional and scientific sources for reference. It is not medical advice and not a substitute for a qualified practitioner. Some plants carry safety cautions and drug interactions — always check before use.

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