Herbal Remedies by Symptom

Low mood / depression - Medicinal Plants & Herbal Remedies

The Omnia Sana plant database documents 8 medicinal plants traditionally used for low mood / depression. Each is rated by strength of evidence and linked to its full monograph and cited scientific sources.

Also known as: low mood, mild depression.

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Psilocybin mushroomsPsilocybe cubensis
Strong evidence

Psilocybin-assisted therapy reduced depression in clinical trials

SaffronCrocus sativus
Strong evidence

RCTs and a meta-analysis report that saffron (stigma, and petal in one trial) improves symptoms of mild-to-moderate depression compared with placebo, and performed similarly to imipramine in a pilot trial. Trials are small and mostly from Iran.

Perforate St John’s-wortHypericum perforatum
Strong evidence

Cochrane review and meta-analysis: hypericum extracts are superior to placebo and comparable to standard antidepressants (including SSRIs) in mild-to-moderate major depression, with fewer side effects. Evidence for severe depression is lacking.

Black CohoshActaea racemosa
Good evidence

Reduces neurovegetative and psychological menopausal symptoms (including anxiety and low mood)

Lemon balmMelissa officinalis
Good evidence

Meta-analysis of clinical trials: lemon balm may improve depressive and anxiety symptoms, particularly in the acute setting; trials are few and heterogeneous.

Sweet FlagAcorus calamus
Good evidence

inferred from antidepressant action

VervainVerbena officinalis
Preliminary evidence

inferred from antidepressant action

Educational information compiled from the Omnia Sana plant database. Not medical advice - always consult a qualified practitioner before using medicinal plants.