Omnia SanaCommon names in 7 European languages →
The complete database record: 4 documented constituents, 6 pharmacological actions, 10 traditional / indicated uses, with 20 cited sources.
Botanical Description
Evergreen tree (Oleaceae), typically 3-15 m tall, often gnarled and long-lived, with some specimens surviving for centuries. Leaves are narrow, leathery, lance-shaped, dark green above and silvery-grey beneath. Small, fragrant, creamy-white four-lobed flowers are borne in axillary clusters, followed by a fleshy drupe (the olive) that ripens from green to purple-black.[1]
Habitat & Distribution
Native to the Mediterranean basin, the Near East and parts of Africa, and cultivated for millennia across Mediterranean-type climates worldwide (warm, dry summers and mild winters); tolerates poor, rocky, calcareous soils and drought.[1]
Harvesting
Leaves can be harvested year-round from pruned or fallen branches, generally at their highest oleuropein content in late autumn and winter; fruit is hand- or machine-harvested from early autumn (green olives) through winter (fully ripe black olives), depending on the intended product.[10]
Key Constituents
The principal bioactive phenolics of the leaf, responsible for most of its antioxidant, anti-inflammatory and antihypertensive activity.
Antioxidant flavonoids of the leaf.
Pentacyclic triterpenes of the leaf cuticle and fruit skin, studied for anti-inflammatory and metabolic effects.
The dominant fatty acid of the fruit oil, a key component of the Mediterranean-diet lipid profile.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from antidiabetic action
more plants for blood sugar / diabetes support →detailed sources →
inferred from anticancer action
more plants for cancer (anticancer research) →detailed sources →
more plants for cardiovascular / heart health →detailed sources →
inferred from antiviral action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from antidiabetic action
inferred from anti-inflammatory action
inferred from antimicrobial action
Traditional Use & History
Olive leaf and fruit have a long Mediterranean tradition as a tonic, antipyretic and mild antihypertensive remedy, and olive oil is the foundation fat of the traditional Mediterranean diet, long associated with cardiovascular health. Modern research on oleuropein and other leaf polyphenols supports antioxidant, anti-inflammatory, antimicrobial, blood-pressure-lowering and insulin-sensitising effects consistent with these traditional and dietary uses.[1, 4, 7]
Preparations
Dosage
A meta-analysis of trials for blood pressure used around 500 mg/day of standardised olive leaf extract. Educational reference only, not a prescription; culinary olive oil and leaf tea are considered food-safe at normal dietary amounts.
Safety, Cautions & Contraindications
Olive leaf extract may lower blood pressure; use caution if already on antihypertensive medication. May have mild hypoglycaemic effects. Olive oil is safe for dietary use. Rare olive pollen allergy. Well tolerated in normal culinary and supplement doses.
Duke (2002) includes olive leaf as ++ and notes hypotensive, hypoglycemic, ACE inhibitor-like, and antioxidant activities at the experimental level (score 1). Olive leaf extract (containing oleuropein) has demonstrated blood pressure-lowering and antiarrhythmic effects consistent with clinical support (PHR). Duke notes that traditional Mediterranean use for both the leaf and fruit is food-grade and safe. Olive leaf preparations are used as mild antihypertensives in European phytotherapy. No significant adverse effects are reported at standard herbal doses (Duke, 2002).
Herb-Drug Interactions
Herb-Herb Pairings
Olive leaf and black seed (Nigella sativa) can each mildly lower blood pressure, so taking them together - especially alongside blood-pressure medicines - may add up and lower blood pressure more than expected. Monitor your blood pressure.
Harvest Readiness
[11]
[12]
External Identifiers
References & Sources
- Omar, S.H., Kerr, P.G., Scott, C.J., Hamlin, A.S. and others (2017) 'Olive (Olea europaea L.) Biophenols: A Nutriceutical against Oxidative Stress in SH-SY5Y Cells', Molecules, 22(11), pp. 1858. doi:10.3390/molecules22111858 Preclinical
https://doi.org/10.3390/molecules22111858 - Ruzzolini, J., Peppicelli, S., Andreucci, E., Bianchini, F. and others (2018) 'Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies', Nutrients, 10(12), pp. 1950. doi:10.3390/nu10121950 Preclinical
https://doi.org/10.3390/nu10121950 - Al-Rimawi, F., Sbeih, M., Amayreh, M., Rahhal, B. and others (2024) 'Evaluation of the antibacterial and antifungal properties of oleuropein, Olea europaea leaf extract, and Thymus vulgaris oil', BMC Complementary Medicine and Therapies, 24(1), pp. 297. doi:10.1186/s12906-024-04596-x Preclinical
https://doi.org/10.1186/s12906-024-04596-x - Qabaha, K., Al-Rimawi, F., Qasem, A. and Naser, S.A (2018) 'Oleuropein Is Responsible for the Major Anti-Inflammatory Effects of Olive Leaf Extract', Journal of Medicinal Food, 21(3), pp. 302-305. doi:10.1089/jmf.2017.0070 Preclinical
https://doi.org/10.1089/jmf.2017.0070 - Pang, K.L., Lumintang, J.N. and Chin, K.Y (2021) 'Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review', Nutrients, 13(2), pp. 529. doi:10.3390/nu13020529 Meta-analysis / review
https://doi.org/10.3390/nu13020529 - Kheirandish, F., Mosaffa, N., Tarahi, M.J. and Fallahi, S (2018) 'Olive (Olea europaea) leaf extract alters the cytokine profile of Leishmania major-infected macrophages: New insight into the underlying mechanism', Parasite Immunology, 40(4), pp. e12520. doi:10.1111/pim.12520 Preclinical
https://doi.org/10.1111/pim.12520 - de Bock, M., Derraik, J.G., Brennan, C.M., Biggs, J.B. and others (2013) 'Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial', PLoS One, 8(3), pp. e57622. doi:10.1371/journal.pone.0057622 Randomized trial
https://doi.org/10.1371/journal.pone.0057622 - Pasban-Aliabadi, H., Esmaeili-Mahani, S., Sheibani, V., Abbasnejad, M. and others (2013) 'Inhibition of 6-hydroxydopamine-induced PC12 cell apoptosis by olive (Olea europaea L.) leaf extract is performed by its main component oleuropein', Rejuvenation Research, 16(2), pp. 134-142. doi:10.1089/rej.2012.1384 Preclinical
https://doi.org/10.1089/rej.2012.1384 - Imperatrice, M., Lasfar, A., van Kalkeren, C.A.J. and Troost, F (2024) 'Olive Leaf Extract Supplementation Improves Postmenopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Parallel Study on Postmenopausal Women', Nutrients, 16(22), pp. 3879. doi:10.3390/nu16223879 Randomized trial
https://doi.org/10.3390/nu16223879 - de Bock, M., Thorstensen, E.B., Derraik, J.G., Henderson, H.V. and others (2013) 'Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract', Molecular Nutrition & Food Research, 57(11), pp. 2079-2085. doi:10.1002/mnfr.201200795 Preclinical
https://doi.org/10.1002/mnfr.201200795 - Plants For A Future 'Olea europaea (Olive)'. Available at: https://pfaf.org/user/Plant.aspx?LatinName=Olea+europaea Traditional / reference
https://pfaf.org/user/Plant.aspx?LatinName=Olea+europaea - Losada-Echeberr\'ia, Mar\'ia and Naranjo, Gustavo and Malouche, Dhafer and Taamalli, Amani and Barraj\'on-Catal\'an, Enrique and Micol, Vicente (2022) 'Influence of Drying Temperature and Harvesting Season on Phenolic Content and Antioxidant and Antiproliferative Activities of Olive (Olea europaea) Leaf Extracts', International Journal of Molecular Sciences, 24(1), pp. 54. doi:10.3390/ijms24010054 Preclinical
https://doi.org/10.3390/ijms24010054 - Ismail, M.A., Norhayati, M.N. and Mohamad, N (2021) 'Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a systematic review and meta-analysis', PeerJ, 9, pp. e11173. doi:10.7717/peerj.11173 Meta-analysis / review
https://doi.org/10.7717/peerj.11173 - Boskov Hansen, H.C. et al (2012) 'Oleocanthal, a phenolic derived from virgin olive oil: a review of the beneficial effects on inflammatory disease', 13(9), pp. 11628--11670. doi:10.3390/ijms150712323 Traditional / reference
https://doi.org/10.3390/ijms150712323 - Wainstein, J. et al (2012) 'Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats', 15(7), pp. 605--610. doi:10.1089/jmf.2011.0243 Randomized trial
https://doi.org/10.1089/jmf.2011.0243 - Waterman, E. and Lockwood, B (2007) 'Active components and clinical applications of olive oil', 12(4), pp. 331--342. Preclinical
https://scholar.google.com/scholar?q=Active%20components%20and%20clinical%20applications%20of%20olive%20oil - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - de Bock, M., Derraik, J.G.B., Brennan, C.M., Biggs, J.B., Morgan, P.E., Hodgkinson, S.C., Hofman, P.L. and Cutfield, W.S (2013) 'Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial', PLoS One, 8(3), pp. e57622. doi:10.1371/journal.pone.0057622 Randomized trial
https://doi.org/10.1371/journal.pone.0057622 - Willcox, M.L., Elugbaju, C., Al-Anbaki, M., Lown, M. and Graz, B (2021) 'Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials', Frontiers in Pharmacology, 12, pp. 777561. doi:10.3389/fphar.2021.777561 Meta-analysis / review
https://doi.org/10.3389/fphar.2021.777561 - Sahebkar, A., Soranna, D., Liu, X., Thomopoulos, C., Simental-Mendia, L.E., Derosa, G., Maffioli, P. and Parati, G (2016) 'A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure', Journal of Hypertension, 34(11), pp. 2127-2135. doi:10.1097/HJH.0000000000001049 Meta-analysis / review
https://doi.org/10.1097/HJH.0000000000001049
Selected studies & references
All 18 studies in the Knowledge Finder →
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