Plant Comparison

Rhodiola Rosea vs Ashwagandha

A side-by-side comparison of two medicinal plants - every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant ARhodiola RoseaRhodiola roseaCrassulaceaeFull monograph →
Plant BAshwagandhaWithania somniferaSolanaceaeFull monograph →

At a glance

Rhodiola Rosea and Ashwagandha: they share 7 indicated uses (arthritis / joint pain, cognitive function, fatigue / low energy, …); 6 pharmacological actions in common.

Rhodiola RoseaAshwagandha
Constituents33
Pharmacological actions68
Indicated uses119
Safety notes22
Cited sources1917
Indicated uses
Only Rhodiola Rosea
Blood sugar / diabetes supportCold & fluImmune supportMetabolic support
Shared (7)
Arthritis / joint painCognitive functionFatigue / low energyInflammation (general)MemoryMuscle sorenessSkin irritation
Only Ashwagandha
Cancer (anticancer research)Insomnia / sleeplessness
Pharmacological actions
Only Rhodiola Rosea
none
Shared (6)
Anti-inflammatoryAntidiabetic (blood-sugar lowering)AntioxidantPhysical performance / ergogenicImmunomodulator / immune supportNeuroprotective / cognition support
Only Ashwagandha
Anticancer (preclinical)Sedative / sleep support

Evidence face-off - shared uses

ConditionRhodiola RoseaAshwagandhaVerdict
Arthritis / joint pain2/10n/aStronger for Rhodiola Rosea
Cognitive function6/10n/aStronger for Rhodiola Rosea
Fatigue / low energy10/10n/aStronger for Rhodiola Rosea
Inflammation (general)7/10n/aStronger for Rhodiola Rosea
Memory5/10n/aStronger for Rhodiola Rosea
Muscle soreness7/10n/aStronger for Rhodiola Rosea
Skin irritation2/10n/aStronger for Rhodiola Rosea

Evidence scores (1-10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Rosavins (rosavin, rosarin, rosin)[3]

Characteristic phenylpropanoid glycosides largely unique to Rhodiola rosea, used as a standardisation marker for commercial extracts.

Salidroside and tyrosol[3]

Phenylethanoid glycosides considered key adaptogenic and antioxidant constituents.

Phenylpropanoids and flavonoids[2]

Contribute to the anti-inflammatory and antioxidant activity of the root.

Flavonoids
Withanolides (withaferin A, withanolide A)[5]

Steroidal lactones considered the principal bioactive compounds, responsible for most of the plant's adaptogenic, anti-inflammatory and anticancer research interest.

Withanolides
Alkaloids (withanine, somniferine)[5]

Minor tropane-type alkaloids contributing to the traditional sedative reputation.

Alkaloids
Sitoindosides and saponins[5]

Glycowithanolides linked to adaptogenic and immunomodulatory activity.

Saponins

Pharmacological Actions

Anti-inflammatory[2, 3, 9, 13, 14]
Antidiabetic (blood-sugar lowering)[3, 13, 14]
Antioxidant[3, 13, 14]
Physical performance / ergogenic[3, 4, 13, 14]

Physical performance / strength improvement

Immunomodulator / immune support[3, 13, 14]
Neuroprotective / cognition support[3, 10, 13, 14]
Anti-inflammatory[5]
Anticancer (preclinical)[11]
Antidiabetic (blood-sugar lowering)
Antioxidant[6]
Physical performance / ergogenic[8, 10]

Physical performance / strength improvement

Immunomodulator / immune support
Neuroprotective / cognition support[2, 6, 9]
Sedative / sleep support[1, 2, 3, 4, 7]

Traditional & Indicated Uses

Arthritis / joint pain[3, 14]Preliminary · 2/10

inferred from anti-inflammatory action

Mechanistic Exclude Ids: REF-0055, REF-1534
Evidence: 2
Label: Arthritis / joint pain
Blood sugar / diabetes support[3, 14]Preliminary · 2/10

inferred from antidiabetic action

Mechanistic Exclude Ids: REF-0055
Evidence: 2
Label: Blood sugar / diabetes support
Cognitive function[3, 5, 13, 14]Moderate · 6/10

inferred from neuroprotective action

Mechanistic Exclude Ids: REF-1535
Evidence: 6
Label: Cognitive function
Cold & flu[3, 14]Preliminary · 2/10

inferred from immunomodulator action

Mechanistic Exclude Ids: REF-0055
Evidence: 2
Label: Cold & flu
Fatigue / low energy[1, 3, 4, 7, 8, 13, 14]Strong · 10/10

inferred from ergogenic action

Evidence: 10
Label: Fatigue / low energy
Immune support[3, 14]Preliminary · 2/10
Mechanistic Exclude Ids: REF-0055
Evidence: 2
Label: Immune support
Inflammation (general)[2, 3, 9, 14]Good · 7/10

inferred from anti-inflammatory action

Mechanistic Exclude Ids: REF-0055
Evidence: 7
Label: Inflammation (general)
Memory[3, 13, 14]Moderate · 5/10

inferred from neuroprotective action

Mechanistic Exclude Ids: REF-1535
Evidence: 5
Label: Memory
Metabolic support[3, 14]Preliminary · 2/10
Mechanistic Exclude Ids: REF-0055
Evidence: 2
Label: Metabolic support
Muscle soreness[3, 4, 14]Good · 7/10

inferred from ergogenic action

Mechanistic Exclude Ids: REF-0055
Evidence: 7
Label: Muscle soreness
Skin irritation[3, 14]Preliminary · 2/10

inferred from anti-inflammatory action

Mechanistic Exclude Ids: REF-0055, REF-1534
Evidence: 2
Label: Skin irritation
Arthritis / joint pain

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Cancer (anticancer research)[11]Good · 7/10

inferred from anticancer action

Evidence: 7
Label: Cancer (anticancer research)
Cognitive function

inferred from neuroprotective action

Mechanistic Exclude Ids: REF-2246
Evidence: 1
Label: Cognitive function
Fatigue / low energy

inferred from ergogenic action

Evidence: 1
Label: Fatigue / low energy
Inflammation (general)

inferred from anti-inflammatory action

Evidence: 1
Label: Inflammation (general)
Insomnia / sleeplessness

inferred from sedative action

Mechanistic Exclude Ids: REF-2247, REF-2248
Evidence: 1
Label: Insomnia / sleeplessness
Memory

inferred from neuroprotective action

Mechanistic Exclude Ids: REF-2246
Evidence: 1
Label: Memory
Muscle soreness

inferred from ergogenic action

Evidence: 1
Label: Muscle soreness
Skin irritation

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation

Safety, Cautions & Contraindications

Safety note[3, 13, 14]Caution

Generally well tolerated. May cause agitation, insomnia, or vivid dreams in sensitive individuals - take in the morning. Avoid in manic episodes or severe anxiety. Theoretical interactions with MAOIs, SSRIs, and CNS stimulants. Avoid during pregnancy and breastfeeding.

Safety note[3, 13, 14, 15]Info

Duke (2002) does not include a dedicated entry for Rhodiola rosea in the Handbook of Medicinal Herbs, Second Edition.

Safety noteCaution

Generally well-tolerated in clinical trials at doses up to 600 mg/day for up to 12 weeks. Common side effects may include mild drowsiness, gastrointestinal upset, and diarrhea at higher doses. Contraindicated during pregnancy due to potential abortifacient effects. May interact with sedatives, immunosuppressants, thyroid medications, and blood sugar medications. People with autoimmune diseases, hyperthyroidism, or scheduled for surgery should consult healthcare providers before use. May cause allergic reactions in sensitive individuals. Not recommended for children without medical supervision.

Safety note[13]Caution

Duke (2002) classifies ashwagandha activities primarily at the experimental level (score 1), with adaptogenic, sedative, immunostimulant, and anti-inflammatory actions demonstrated in animal and in vitro models. Root preparations are used at 2–3 g powdered root three times daily, or 150–300 mg of standardized extract. Importantly, the plant has documented abortifacient and antifertility properties in animal studies, and its use should be avoided during pregnancy. It may potentiate the effects of barbiturates and sedatives (Duke, 2002).

External Ids

Gbif: 2985688
Wikidata: Q161665
Gbif: 2928840
Wikidata: Q852660

Botanical Description

Succulent perennial herb (Crassulaceae), 15-40 cm tall, with a thick, fleshy, branching rhizome that has a rose-like fragrance when cut - the origin of the name 'rosea'. Leaves are fleshy, greyish-green, oval to oblong. Small yellow (occasionally reddish) flowers are clustered in dense terminal heads; the species is dioecious, with separate male and female plants. Fruit follicles turn red as they ripen.[3]

Height: 15-40 cm
Habit: Succulent perennial herb, dioecious
Leaves: Fleshy, greyish-green, oval to oblong
Flowers: Small, yellow (occasionally reddish), in dense terminal clusters
Stem: Erect, succulent
Root: Thick, fleshy, branching rhizome, rose-scented when cut
Fruit: Follicles, turning red as they ripen
Flowering Period: June-July

Erect, branching perennial shrub with soft, downy, oval to lance-shaped leaves. Small, inconspicuous, greenish-yellow bell-shaped flowers are borne in the leaf axils, followed by a small orange-red berry enclosed in a papery, lantern-like calyx, giving rise to the name 'winter cherry'.[5]

Height: 0.3-1.5 m
Habit: Erect, branching perennial shrub
Leaves: Soft, downy, oval to lance-shaped
Flowers: Small, inconspicuous, greenish-yellow, bell-shaped
Stem: Erect, branching, downy
Root: Long, thick, tapering, pale brown root (the medicinal part), aromatic with a distinctive horse-like smell (the source of the name ashwagandha)
Fruit: Small orange-red berry enclosed in a papery, lantern-like calyx
Flowering Period: Summer to autumn

Habitat

Native to arctic and mountainous regions of Europe, Asia and North America (circumpolar), growing in cold, rocky, high-altitude or high-latitude terrain - cliffs, rocky slopes and tundra - tolerating harsh, exposed conditions.[3]

Native to the drier regions of India, the Middle East and parts of Africa; cultivated in warm, semi-arid climates on well-drained soils, notably in central and western India.[5]

Harvesting

Rhizome and root are dug from plants at least a few years old (traditionally 4-5 years), typically in autumn, then cleaned and dried. Wild populations grow slowly, so cultivated sources are increasingly preferred for sustainability.[3]

Parts: Rhizome, Root
Season: Autumn, from plants at least 4-5 years old

The root is dug in winter from plants around one year old, when withanolide content is highest, then cleaned, cut and dried; the leaves are picked through the growing season.[5]

Parts: Leaf, Root
Season: Root in winter, from around one-year-old plants; leaf through the growing season

Harvest Readiness

[11, 12]

Part: rhizome
Signals: Lift only from mature plants: the underground parts are dug once, at the end of the fourth or fifth year of growth., Within a season the rosavin content of the dried rhizome is at its highest at flowering.
Basis: both
Constituent Note: Total rosavins in the dried rhizome peak at flowering, and root dry weight falls to a minimum at budding/full flowering before rising again towards a harvest taken after wilting (ISHS Acta Horticulturae, REF-3385).
Source Quote: Rhodiola rosea is grown as a perennial, but the roots are harvested once at the end of four or five years.
Species Confirmed: 1
Notes: Two complementary sources, not one confirming the other, which is why this stays provisional. Alberta Agriculture Agdex 188/20-2 (REF-3384) gives the maturity rule (fourth or fifth year); the ISHS harvest-time study (REF-3385) gives the within-season phenophase - 'The content of total rosavins in the dry rhizomes was the highest at flowering on both sites'. They address different aspects of readiness and so do not constitute an independent confirmation of the same stage. Supersedes the earlier dead end (PFAF and Useful Temperate Plants gave only flowering and propagation-division timing).

[11, 12]

Part: root
Signals: The root is dug with the rhizome, from mature plants only, at the end of the fourth or fifth year of growth., Root dry weight falls to a minimum around budding and full flowering, then rises again towards a harvest taken after the tops have wilted.
Basis: both
Constituent Note: Rhizomes of R. rosea contain more phenylpropenoids than the roots, and root dry weight is lowest at budding/full flowering, recovering towards the post-wilting harvest (ISHS Acta Horticulturae, REF-3385).
Source Quote: the dry weight of the root decreased until budding/full flowering, followed by an increase towards the last harvest after wilting
Species Confirmed: 1
Notes: ISHS harvest-time study of cultivated Rhodiola rosea at Finnish and Norwegian sites (REF-3385) for the within-season phenophase, plus Alberta Agriculture Agdex 188/20-2 (REF-3384) for the maturity rule, 'the roots are harvested once at the end of four or five years'. The two sources are complementary rather than confirmatory, so this stays provisional. Supersedes the earlier dead end.

[12]

Part: root
Signals: Dig the root in autumn.
Basis: traditional
Source Quote: The root is harvested in the autumn and dried for later use.
Species Confirmed: 1
Notes: PFAF (REF-3369); the root is dug in autumn. Single lineage -> provisional. (Leaf, also a listed part, is gathered through the growing season but was not separately timing-sourced this pass.)

Traditional Uses

Rhodiola has a long tradition of use across Scandinavian, Russian and Central Asian folk medicine as a tonic for cold-climate hardiness, physical endurance and mental stamina. It is classified as a modern 'adaptogen', and clinical trials support benefits for stress-related fatigue, mood and cognitive performance.[1, 3]

Ashwagandha root is one of the most important rasayana (rejuvenative) tonics of Ayurvedic medicine, traditionally used to build strength and vitality, support healthy stress response, and promote restful sleep; this traditional adaptogenic reputation is now supported by clinical trials of standardised root extract for stress, sleep and physical performance.[1, 5]

Preparations

Standardised root extract (capsule)[7, 8]

Standardised to rosavins and salidroside (commonly the SHR-5 extract), the form used in most clinical trials.

Standardised extract[1, 5]

Root extract standardised to withanolide content, taken as capsules or tablets; the form used in most clinical stress, sleep and performance studies.

Dosage

Standardised extract[7, 8]

Clinical trials have most often used 340-680 mg/day of standardised root extract (e.g. SHR-5, standardised to rosavins/salidroside), typically taken in the morning to avoid overstimulation. Educational reference only, not a prescription.

Standardised extract[1]

Clinical trials for stress and sleep commonly use around 300-600 mg of standardised root extract daily, in divided doses, over several weeks. Educational reference only, not a prescription.

References

REF-1526, REF-1527, REF-1528, REF-1529, REF-1530, REF-1531, REF-1532, REF-1533, REF-1534, REF-1535
REF-2245, REF-2246, REF-2247, REF-2248, REF-2249, REF-2250, REF-2251, REF-2252, REF-2253, REF-2254, REF-2255

Drug Class Interactions

Antidepressants Serotonergic[16, 17]Caution
Mechanism: Rhodiola inhibits monoamine oxidase (MAO-A/B) and raises serotonin and dopamine activity; a case report described serotonergic-syndrome-type symptoms (restlessness, trembling) when rhodiola was added to the antidepressant paroxetine. Combined with antidepressants it may add to serotonergic effects.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03
Thyroid Medicines[14, 15]Caution
Mechanism: Ashwagandha can raise circulating thyroid hormone (T3/T4) and lower TSH; a randomized trial normalised thyroid indices in subclinical hypothyroidism and a case of thyrotoxicosis has been reported. Combined with thyroid medication it may add to thyroid activity, so monitor thyroid levels.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03
Sedatives Cns Depressants[1, 16]Caution
Mechanism: Ashwagandha has sedative, GABA-related calming activity (a meta-analysis of randomised trials found it improves sleep); taken with sedatives, sleeping tablets or other central-nervous-system depressants it may add to drowsiness and slowed reactions.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03
Antidiabetics[17]Caution
Mechanism: Ashwagandha can lower blood glucose; combined with diabetes medicines it may add to blood-sugar lowering and increase the risk of hypoglycaemia, so monitor blood sugar.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Pairings

Eleutherococcus Senticosus[18, 19]

Rhodiola and eleuthero (Siberian ginseng) are classic adaptogens combined in traditional and studied fixed formulas to build resistance to stress and fatigue; used together their stress-protective effects are complementary.

Type: synergy
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03
Schisandra Chinensis[18, 19]

Rhodiola and schisandra are adaptogens co-formulated in clinically studied combinations for stress, fatigue and mental performance; combined use is intended to be synergistic rather than harmful.

Type: synergy
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03
Valeriana Officinalis[1, 16]

Both ashwagandha and valerian are calming, sleep-promoting herbs; using them together may add to drowsiness and sedation, so take care especially before driving or when using other sedatives.

Type: caution
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03
Piper Methysticum[1, 16]

Ashwagandha and kava both calm the central nervous system; combining them may add to sedation and drowsiness, so combined use warrants caution.

Type: caution
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Lookalikes Review

Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

References & Sources

  1. Ivanova Stojcheva, E. and Quintela, J.C (2022) 'The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions - Encouraging Clinical Evidence', Molecules, 27(12), pp. 3902. doi:10.3390/molecules27123902 Meta-analysis / review
    https://doi.org/10.3390/molecules27123902
  2. Pu, W.L., Zhang, M.Y., Bai, R.Y., Sun, L.K. and others (2019) 'Anti-inflammatory effects of Rhodiola rosea L.: A review', Biomedicine & Pharmacotherapy, 121, pp. 109552. doi:10.1016/j.biopha.2019.109552 Meta-analysis / review
    https://doi.org/10.1016/j.biopha.2019.109552
  3. Panossian, A., Wikman, G. and Sarris, J (2010) 'Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy', Phytomedicine, 17(7), pp. 481-493. doi:10.1016/j.phymed.2010.02.002 Preclinical
    https://doi.org/10.1016/j.phymed.2010.02.002
  4. Tinsley, G.M., Jagim, A.R., Potter, G.D.M., Garner, D. and Galpin, A.J (2023) 'Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature', The British Journal of Nutrition, 131(3), pp. 461-473. doi:10.1017/S0007114523001988 Meta-analysis / review
    https://doi.org/10.1017/S0007114523001988
  5. Cropley, M., Banks, A.P. and Boyle, J (2015) 'The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms', Phytotherapy Research, 29(12), pp. 1934-1939. doi:10.1002/ptr.5486 Randomized trial
    https://doi.org/10.1002/ptr.5486
  6. Amsterdam, J.D. and Panossian, A.G (2016) 'Rhodiola rosea L. as a putative botanical antidepressant', Phytomedicine, 23(7), pp. 770-783. doi:10.1016/j.phymed.2016.02.009 Meta-analysis / review
    https://doi.org/10.1016/j.phymed.2016.02.009
  7. Olsson, E.M., von Scheele, B. and Panossian, A.G (2009) 'A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue', Planta Medica, 75(2), pp. 105-112. doi:10.1055/s-0028-1088346 Randomized trial
    https://doi.org/10.1055/s-0028-1088346
  8. Ishaque, S., Shamseer, L., Bukutu, C. and Vohra, S (2012) 'Rhodiola rosea for physical and mental fatigue: a systematic review', BMC Complementary and Alternative Medicine, 12, pp. 70. doi:10.1186/1472-6882-12-70 Meta-analysis / review
    https://doi.org/10.1186/1472-6882-12-70
  9. Borgonetti, V., Governa, P., Biagi, M., Dalia, P. and Corsi, L (2019) 'Rhodiola rosea L. modulates inflammatory processes in a CRH-activated BV2 cell model', Phytomedicine, 68, pp. 153143. doi:10.1016/j.phymed.2019.153143 Preclinical
    https://doi.org/10.1016/j.phymed.2019.153143
  10. Coors, A., Brosch, M., Kahl, E., Khalil, R. and others (2019) 'Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating', Journal of Ethnopharmacology, 235, pp. 320-328. doi:10.1016/j.jep.2019.02.031 Preclinical
    https://doi.org/10.1016/j.jep.2019.02.031
  11. Alberta Agriculture and Rural Development (2010) 'Rhodiola rosea: A High Value Crop (Agdex 188/20-2)'. Available at: https://www1.agric.gov.ab.ca/$department/deptdocs.nsf/all/agdex13054/$file/188_20-2.pdf Traditional / reference
    https://www1.agric.gov.ab.ca/$department/deptdocs.nsf/all/agdex13054/$file/188_20-2.pdf
  12. International Society for Horticultural Science 'Harvest time and drying temperature effect on secondary metabolites in Rhodiola rosea', Acta Horticulturae, (955), pp. 245--250. Available at: https://ishs.org/ishs-article/955_35/ Preclinical
    https://ishs.org/ishs-article/955_35/
  13. Darbinyan, V. et al (2000) 'Rhodiola rosea in stress induced fatigue — a double blind cross-over study of a standardized extract SHR-5', 7(5), pp. 365--371. Randomized trial
    https://scholar.google.com/scholar?q=Rhodiola%20rosea%20in%20stress%20induced%20fatigue%20%E2%80%94%20a%20double%20blind%20cross-over%20study%20of%20a%20standardized%20extract%20SHR-5
  14. Kelly, G.S (2001) 'Rhodiola rosea: a possible plant adaptogen', 6(3), pp. 293--302. Traditional / reference
    https://scholar.google.com/scholar?q=Rhodiola%20rosea%3A%20a%20possible%20plant%20adaptogen
  15. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  16. Maniscalco, I., Toffol, E., Giupponi, G. and Conca, A (2014) 'The interaction of Rhodiola rosea and antidepressants. A case report', Neuropsychiatrie, 29(1), pp. 36-38. doi:10.1007/s40211-014-0124-8 Clinical study
    https://doi.org/10.1007/s40211-014-0124-8
  17. van Diermen, D., Marston, A., Bravo, J., Reist, M., Carrupt, P.A. and Hostettmann, K (2009) 'Monoamine oxidase inhibition by Rhodiola rosea L. roots', Journal of Ethnopharmacology, 122(2), pp. 397-401. doi:10.1016/j.jep.2009.01.007 Preclinical
    https://doi.org/10.1016/j.jep.2009.01.007
  18. Panossian, A.G (2013) 'Adaptogens in mental and behavioral disorders', Psychiatric Clinics of North America, 36(1), pp. 49-64. doi:10.1016/j.psc.2012.12.005 Meta-analysis / review
    https://doi.org/10.1016/j.psc.2012.12.005
  19. Karosanidze, I., Kiladze, U., Kirtadze, N., Giorgadze, M. and Panossian, A (2022) 'Efficacy of Adaptogens in Patients with Long COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial', Pharmaceuticals, 15(3), pp. 345. doi:10.3390/ph15030345 Randomized trial
    https://doi.org/10.3390/ph15030345
  1. Cheah, K.L., Norhayati, M.N., Husniati Yaacob, L. and Abdul Rahman, R (2021) 'Effect of Ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis', PLoS One, 16(9), pp. e0257843. doi:10.1371/journal.pone.0257843 Meta-analysis / review
    https://doi.org/10.1371/journal.pone.0257843
  2. Speers, A.B., Cabey, K.A., Soumyanath, A. and Wright, K.M (2021) 'Effects of Withania somnifera (ashwagandha) on stress and the stress-related neuropsychiatric disorders anxiety, depression, and insomnia', Current Neuropharmacology, 19(9), pp. 1468-1495. doi:10.2174/1570159X19666210712151556 Meta-analysis / review
    https://doi.org/10.2174/1570159X19666210712151556
  3. Arumugam, V., Vijayakumar, V., Balakrishnan, A., B Bhandari, R., Boopalan, D., Ponnurangam, R., Sankaralingam Thirupathy, V. and Kuppusamy, M (2024) 'Effects of Ashwagandha (Withania somnifera) on stress and anxiety: a systematic review and meta-analysis', Explore, 20(6), pp. 103062. doi:10.1016/j.explore.2024.103062 Meta-analysis / review
    https://doi.org/10.1016/j.explore.2024.103062
  4. Lopresti, A.L., Smith, S.J., Malvi, H. and Kodgule, R (2019) 'An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study', Medicine, 98(37), pp. e17186. doi:10.1097/MD.0000000000017186 Randomized trial
    https://doi.org/10.1097/MD.0000000000017186
  5. Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S.C., Patil, M.T., Kandimalla, R. and Prockow, J (2021) 'Withania somnifera (L.) Dunal (Ashwagandha): a comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects', Biomedicine & Pharmacotherapy, 143, pp. 112175. doi:10.1016/j.biopha.2021.112175 Meta-analysis / review
    https://doi.org/10.1016/j.biopha.2021.112175
  6. Dar, N.J., Hamid, A. and Ahmad, M (2015) 'Pharmacologic overview of Withania somnifera, the Indian ginseng', Cellular and Molecular Life Sciences, 72(23), pp. 4445-4460. doi:10.1007/s00018-015-2012-1 Meta-analysis / review
    https://doi.org/10.1007/s00018-015-2012-1
  7. Pandit, S., Srivastav, A.K., Sur, T.K., Chaudhuri, S., Wang, Y. and Biswas, T.K (2024) 'Effects of Withania somnifera extract in chronically stressed adults: a randomized controlled trial', Nutrients, 16(9), pp. 1293. doi:10.3390/nu16091293 Randomized trial
    https://doi.org/10.3390/nu16091293
  8. Wankhede, S., Langade, D., Joshi, K., Sinha, S.R. and Bhattacharyya, S (2015) 'Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial', Journal of the International Society of Sports Nutrition, 12, pp. 43. doi:10.1186/s12970-015-0104-9 Randomized trial
    https://doi.org/10.1186/s12970-015-0104-9
  9. Choudhary, D., Bhattacharyya, S. and Bose, S (2017) 'Efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions', Journal of Dietary Supplements, 14(6), pp. 599-612. doi:10.1080/19390211.2017.1284970 Randomized trial
    https://doi.org/10.1080/19390211.2017.1284970
  10. Tiwari, S., Gupta, S.K. and Pathak, A.K (2021) 'A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults', Journal of Ethnopharmacology, 272, pp. 113929. doi:10.1016/j.jep.2021.113929 Randomized trial
    https://doi.org/10.1016/j.jep.2021.113929
  11. Singh, N., Yadav, S.S., Rao, A.S., Nandal, A., Kumar, S., Ganaie, S.A. and Narasihman, B (2020) 'Review on anticancerous therapeutic potential of Withania somnifera (L.) Dunal', Journal of Ethnopharmacology, 270, pp. 113704. doi:10.1016/j.jep.2020.113704 Meta-analysis / review
    https://doi.org/10.1016/j.jep.2020.113704
  12. Plants For A Future 'Withania somnifera (Ashwagandha, Winter Cherry)'. Available at: https://pfaf.org/user/Plant.aspx?LatinName=Withania+somnifera Traditional / reference
    https://pfaf.org/user/Plant.aspx?LatinName=Withania+somnifera
  13. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  14. Sharma, A.K., Basu, I. and Singh, S (2018) 'Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial', Journal of Alternative and Complementary Medicine, 24(3), pp. 243-248. doi:10.1089/acm.2017.0183 Randomized trial
    https://doi.org/10.1089/acm.2017.0183
  15. Gannon, J.M., Forrest, P.E. and Roy Chengappa, K.N (2014) 'Subtle changes in thyroid indices during a placebo-controlled study of an extract of Withania somnifera in persons with bipolar disorder', Journal of Ayurveda and Integrative Medicine, 5(4), pp. 241-245. doi:10.4103/0975-9476.146566 Clinical study
    https://doi.org/10.4103/0975-9476.146566
  16. Caus, M.N., Lupoae, M. and Chitescu, C.L (2026) 'Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks', Pharmaceuticals, 19(3), pp. 399. doi:10.3390/ph19030399 Meta-analysis / review
    https://doi.org/10.3390/ph19030399
  17. Makhlouf, E.A., AlamElDeen, Y.K., El-Shiekh, R.A. and Okba, M.M (2024) 'Unveilling the antidiabetic potential of ashwagandha (Withania somnifera L.) and its withanolides - a review', Natural Product Research, 39(24), pp. 7203-7218. doi:10.1080/14786419.2024.2439009 Meta-analysis / review
    https://doi.org/10.1080/14786419.2024.2439009
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only - not medical advice. Always consult a qualified practitioner before using medicinal plants.

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