Symptom → Plant Sources
Japanese knotweed (Reynoutria japonica) as a tool for helping with Skin irritation
inferred from anti-inflammatory action
← Back to Symptom-to-Plant Lookup
Full Japanese knotweed monograph →All plants for skin irritation →
Stilbenes, in particular trans-resveratrol and its glucoside, are widely reported to be beneficial to health, having been shown to possess antioxidative, anticarcinogenic, and antitumor properties. Major dietary sources include grapes, wine, peanuts, and soy; however, they can also be introduced into the diet through Itadori tea, which has long been used in Japan and China as a traditional herbal remedy for heart disease and strokes. Analysis of grapes, peanuts, and Itadori tea shows that they contain mainly trans-resveratrol glucoside. In contrast, red wines are primarily a source of the aglycones cis- and trans-resveratrol. While peanuts and grapes contain low levels of the stilbenes, Itadori tea and red wine both supply relatively high concentrations of resveratrol. For people who do not consume alcohol, Itadori tea may be a suitable substitute for red wine. However, further study on the potential biological effects of other endogenous compounds in Itadori tea is required and there is also a need for more information on the absorption and in vivo biomedical actions of free and conjugated resveratrol.
3 sources supporting Japanese knotweed for Skin irritation. Includes scientific publications, books, monographs and traditional-use references.
Mechanistic basis
This use is associated with the plant's anti-inflammatory action. Further evidence for that pharmacology:
Emodin, a natural anthraquinone derivative and a major bioactive constituent of Polygonum cuspidatum (Reynoutria japonica), possesses anticancer, hepatoprotective, anti-inflammatory, antioxidant and antimicrobial activities, but can also cause toxicity at high doses. This review summarises the pharmacology, toxicity and pharmacokinetics of emodin.
This systematic review evaluated Reynoutria japonica (Huzhang) for acute respiratory tract infections in adults and children, finding evidence that Chinese herbal medicine containing Reynoutria japonica has anti-inflammatory and antiviral effects relevant to respiratory infection.
Reynoutria japonica (Polygonum cuspidatum, Huzhang), whose root has a long history as a Chinese medicinal plant, has anti-inflammatory, antitumour, antioxidant, antiviral, cardioprotective and neuroprotective pharmacological activities. This review summarises advances in its pharmacological activities and active constituents (resveratrol, polydatin, emodin).
The dried roots and rhizomes of Polygonum cuspidatum (Reynoutria japonica) are used as medicinal herbs. This review summarises the extraction, purification, structure and biological activities of its polysaccharides, including antioxidant, anti-inflammatory, immunomodulatory and antitumour effects.
Polygonum cuspidatum (Reynoutria japonica, Huzhang) is a traditional Chinese medicinal herb. This review covers its botany, phytochemistry (resveratrol, polydatin, emodin, anthraquinones), and pharmacology, including anti-inflammatory, antioxidant, anticancer, cardiovascular-protective, antimicrobial and antiviral activities.
Using network pharmacology, this study explored the multicomponent, multitarget mechanism by which Polygonum cuspidatum (Reynoutria japonica) may act against osteoarthritis, identifying anti-inflammatory targets relevant to the treatment of joint disease.