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Field restharrow (Ononis arvensis) and Pain (general): evidence and sources
inferred from analgesic action
For educational purposes only, not medical advice. Always consult a qualified practitioner before using medicinal plants, especially alongside prescribed medication, during pregnancy, or for a serious condition.
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The present study investigated the analgesic and hepatoprotective activities of a water extract of Ononis spinosa L. (OS) in mice. Analgesic activity was based on the pain thresholds measured with the tail-flick test before administration at 30, 90 and 150 min. The results were analysed with one-way variance analysis. The extract of Ononis spinosa showed analgesic activity equivalent to aspirin at 30 and 90 min and even higher than aspirin with the 50 mg/kg dose. At a dose of 100 mg/kg OS showed an analgesic effect equivalent to aspirin at all time points.The hepatoprotective influence of OS on carbon tetrachloride (CCl(4))-induced acute liver toxicity was also studied. The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05). Thus, the results reveal that the extract of OS had no hepatoprotective effect on CCl(4)-induced acute liver toxicity.
1 source supporting Field restharrow for Pain (general). Includes scientific publications, books, monographs and traditional-use references.
Mechanistic basis
This use is associated with the plant's analgesic (pain relief) action. Further evidence for that pharmacology:
Ononis spinosa (spiny restharrow) is a perennial herb that belongs to the family Fabaceae with many non-sticky hanging stems, trifoliate serrate leaflets and pink-violet flowers (1). This plant is widespread in the Mediterranean region of Europe, in West Asia and North Africa (2, 3). O. spinosa is used for treating kidney stones and inflammatory diseases (4) and healing wounds (5). In fact, ononidis radix; the dried roots of O. spinosa are commercially available in different forms for various uses. The herbal tea of this plant is taken mainly as a diuretic and for rheumatism (3).