Bioactive amides from Reynoutria japonica

Abstract

One pair of new amides enantiomers ( 1a and 1b ) and two known amides were isolated from the rhizomes of Polygonum cuspidatum . Their structures were established using UV, IR, HRESIMS, and NMR data. Notably, compound 1 possesses unique C-C connection between feruloyltyramine and resveratrol. Their absolute configurations were determined by the ECD method. All compounds were evaluated for their α -glucosidase inhibitory activity and compounds 2 and 3 showed significant inhibitory activity with IC 50 values of 2.82 and 13.06 μmol/L, respectively (positive control acarbose, IC 50 385 μmol/L).