Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action
Abstract
A systematic review of six randomized, double-blind clinical trials of saffron for depression. In placebo-comparison trials saffron had large treatment effects, and compared with antidepressant medications it had similar antidepressant efficacy. Saffron's antidepressant effects are potentially due to its serotonergic, antioxidant, anti-inflammatory, neuro-endocrine and neuroprotective actions, providing initial support for its use in mild-to-moderate depression.
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How to cite
Lopresti, A.L. and Drummond, P.D (2014) 'Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action', Human Psychopharmacology, 29(6), pp. 517-527. doi:10.1002/hup.2434
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