Trypanocidal terpenoids from Laurus nobilis L.

Uchiyama, N., Matsunaga, K., Kiuchi, F., Honda, G., Tsubouchi, A. and Nakajima-Shimada, J. · Chemical & Pharmaceutical Bulletin · 2002

Preclinical

View original source →

Abstract

Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 microM, respectively.

Referenced for these plants

How to cite

Uchiyama, N., Matsunaga, K., Kiuchi, F., Honda, G., Tsubouchi, A. and Nakajima-Shimada, J (2002) 'Trypanocidal terpenoids from Laurus nobilis L', Chemical & Pharmaceutical Bulletin, 50(11), pp. 1514-1516. doi:10.1248/cpb.50.1514

This reference is part of the evidence base for the Omnia Sana plant database. Source links open the original publication; Omnia Sana does not host third-party content.