Journal

Goldenseal

July 2, 2026 · Omnia Sana
Hydrastis canadensis
Family: Ranunculaceae  ·  Parts used: Rhizome and root  ·  Also known as: Orange root, Yellow root, Ground raspberry

Key actions

Anti-inflammatoryAntimicrobialAstringentDigestive aid

Traditional & clinical uses, by strength of evidence

  • Arthritis / joint painModerate
  • BloatingModerate
  • DiarrhoeaModerate
  • IndigestionModerate
  • Infection (general)Moderate
  • Inflammation (general)Moderate
  • Skin irritationModerate
  • Sore throatModerate
  • WoundsModerate

Selected studies & references

ReviewThe effect of berberine on metabolic profiles in type 2 diabetic patients: a systematic review and meta-analysis of randomized controlled trials (2021)
RctGoldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues (2020)
RctSupplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo (2007)
RctIn vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes (2005)
PreclinicalEffects of Hydrastis Canadensis, Commiphora Habessinica, Phytolacca Americana, and Echinacea Purpurea on Bacterial Growth (2021)
PreclinicalPlant isoquinoline alkaloids: Advances in the chemistry and biology of berberine (2021)
PreclinicalModulation of major human liver microsomal cytochromes P450 by component alkaloids of goldenseal: time-dependent inhibition and allosteric effects (2020)
PreclinicalDetection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics (2018)

All 16 studies in the Knowledge Finder →

Educational use only. This profile summarises traditional and scientific sources for reference. It is not medical advice and not a substitute for a qualified practitioner. Some plants carry safety cautions and drug interactions — always check before use.

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