Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo
Randomized trial
Abstract
In a randomized clinical trial, supplementation with goldenseal (Hydrastis canadensis) inhibited human CYP3A activity in vivo, indicating a clinically relevant herb-drug interaction potential of goldenseal.
Referenced for these plants
How to cite
Gurley, B.J., Swain, A., Hubbard, M.A., Hartsfield, F., Thaden, J., Williams, D.K., Gentry, W.B. and Tong, Y (2007) 'Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo', Clinical Pharmacology and Therapeutics, 83(1), pp. 61-69. doi:10.1038/sj.clpt.6100222
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