Symptom → Plant Sources
White Dead Nettle (Lamium album) as a tool for helping with Wounds
Vulnerary (minor wounds), applied topically
2 sources supporting White Dead Nettle for Wounds. Includes scientific publications, books, monographs and traditional-use references.
Mechanistic basis
This use is associated with the plant's astringent, vulnerary (wound healing) actions. Further evidence for that pharmacology:
Background : As part of the efforts to find natural alternatives for cancer treatment and to overcome the barriers of cellular resistance to chemotherapeutic agents, polymeric nanocapsules containing curcumin and/or methotrexate were prepared by an interfacial deposition of preformed polymer method. Methods : Physicochemical properties, drug release experiments and in vitro cytotoxicity of these nanocapsules were performed against the Calu-3 lung cancer cell line. Results : The colloidal suspensions of nanocapsules showed suitable size (287 to 325 nm), negative charge (-33 to -41 mV) and high encapsulation efficiency (82.4 to 99.4%). Spherical particles at nanoscale dimensions were observed by scanning electron microscopy. X-ray diffraction analysis indicated that nanocapsules exhibited a non-crystalline pattern with a remarkable decrease of crystalline peaks of the raw materials. Fourier-transform infrared spectra demonstrated no chemical bond between the drug(s) and polymers. Drug release experiments evidenced a controlled release pattern with no burst effect for nanocapsules containing curcumin and/or methotrexate. The nanoformulation containing curcumin and methotrexate (NCUR/MTX-2) statistically decreased the cell viability of Calu-3. The fluorescence and morphological analyses presented a predominance of early apoptosis and late apoptosis as the main death mechanisms for Calu-3. Conclusions : Curcumin and methotrexate co-loaded nanocapsules can be further used as a novel therapeutic strategy for treating non-small-cell lung cancer.
Butanolic extracts of Lamium album aerial parts showed haemostatic (procoagulant) activity in vitro, providing experimental support for the traditional astringent and styptic use of white dead-nettle.
Lamium album extracts modulated proliferation and morphology of cultured human corneal epithelial cells without marked cytotoxicity, supporting the traditional use of white dead-nettle for mucosal and ocular inflammation.