Symptom → Plant Sources
Ground Elder (Aegopodium podagraria) as a tool for helping with Skin irritation
inferred from anti-inflammatory action
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Full Ground Elder monograph →All plants for skin irritation →
3 sources supporting Ground Elder for Skin irritation. Includes scientific publications, books, monographs and traditional-use references.
Mechanistic basis
This use is associated with the plant's anti-inflammatory action. Further evidence for that pharmacology:
Goutweed (Aegopodium podagraria L.) is a medicinal perennial in the celery family (Apiaceae), also an edible plant of high nutritional value. In traditional folk medicine it was known as a remedy for gout (arthritis) and used to relieve rheumatism or sciatica. Specific metabolites include organic acids, flavonoids, coumarins, polyacetylenes and terpene components of essential oil. Its valuable medicinal properties include anti-inflammatory, antirheumatic, antioxidant, antibacterial, antifungal, diuretic, sedative and protective effects on the kidneys and liver.
Goutweed (Aegopodium podagraria L.) leaves contain polyacetylenes, essential oils, mono- and sesquiterpenes, vitamins, macro- and microelements and phenolic compounds. This study investigated the antioxidant properties of different goutweed leaf extracts and their effects on the THP-1 cell line. Ethanol extracts had a high content of polyphenols, polyacetylenes and essential oil and high antioxidant potential, with positive effects on antioxidant enzyme activity in cells under fluoride-induced oxidative stress.
Bioassay-guided fractionation of Aegopodium podagraria identified the polyacetylene falcarindiol as a potent cyclooxygenase-1 (COX-1) inhibitor (IC50 0.3 microM), providing a mechanistic basis for the anti-inflammatory and traditional anti-rheumatic use of goutweed.