Angelica (Angelica archangelica) and Indigestion: evidence and sources

Background Herbal medicine is widely used in different systems of traditional and complementary medicine including. People believe that herbal medicines are safe and more cost-effective than other synthetic medicines. Herbal medicines are also used as a promising source of new drug discovery molecules in modern medicines. Coumarins are polyphenols class phytochemical that naturally occurs in higher plants and are used in medicine for the treatment of human disorders and associated secondary complications. Columbianetin is a coumarin class phytochemical found in Angelica archangelica L. Methods The aim of the present work is to review the medicinal importance and pharmacological activities of columbianetin and to provide a summary of the medicinal importance and pharmacological activities of columbianetin in medicine. Further scientific progress of columbianetin in the fields of Ethnopharmacology, Phytochemistry and Pharmacology has been analyzed and discussed in the present work. However, possible future research on columbianetin has been also discussed in the present work. Scientific information on columbianetin was collected from PubMed, Elsevier, Google, Google Scholar, and Europe PMC using herbal medicine, columbianetin and coumarin as important keywords. Other published books and journal data have also been included in the present work to know the therapeutic potential of columbianetin in medicine. Results Scientific data analysis of columbianetin signified the biological importance of phytochemicals belonging to the coumarins. Biological effectiveness of coumarins for their antioxidative, cytotoxic, and anti-inflammatory potential has been discussed in the research fields. Columbianetin has analgesic, antioxidative, anti-inflammatory, anti-proliferative, and anti-allergic activities in medicine. However, its biological effectiveness on neuroprotection, keratinocyte damage and platelet aggregation has also been discussed in the present work. Further tissue distribution of columbianetin in different biological tissue has been estimated through different analytical methods and scientific data are also presented in the present work. Conclusion The present work summarized the biological importance and pharmacological activities of columbianetin in medicine. Analytical methods developed for the quantitative and qualitative estimation of columbianetin have also been reviewed.

Plant-derived molecules have enduring usefulness in treating diseases, and herbal drugs have emerged as a vital component of global therapeutic demand. Angelica archangelica L. (A. archangelica), commonly known as garden angelica, is an aromatic food plant used in culinary procedures as a flavoring agent. In the traditional medicine system, it is regarded as an "Angel plant" due to its miraculous curative power. This review aims to provide a comprehensive summary of the plant's taxonomic profile, ethnopharmacology, Phytochemistry, and pharmacological activities. Various in vivo and in vitro experiments have validated that the plant possesses broad pharmacological potential. The biological activities attributed to the plant include anti-anxiety activity, anti-convulsant activity, cognition enhancer, antiviral activity, cholinesterase inhibitory potential, antiinflammatory activity, gastroprotective activity, and radioprotective activity. The beneficial effects of the plant are credited to its bioactive components, that is, coumarins and volatile oils. The review summarizes the pharmacological activities of crude extract and its bioactive fractions and has also explored their target-oriented effects. This review will be of value in undertaking further investigations on the plant with regard to exploring mechanism-based pharmacological approaches on A. archangelica.

The plant Angelica archangelica, owing to its magnificent therapeutic effectiveness in folklore medicine system, has been regarded as an "angel plant." The current investigation was aimed to optimize extraction conditions of A. archangelica roots and to investigate in vivo role of optimized extract in fibromyalgia. Plant material (dried roots) was subjected to methanol extraction at variable temperature (40 to 60 °C) and time (12 to 36 hr) conditions as per two-factorial design strategy, and responses in terms of antioxidant activity were determined. The optimized extraction conditions were found to be temperature of 60 °C and time of 36 hr. HPLC fingerprinting indicated the presence of coumarins in extract. To induce fibromyalgia, the mice were administered reserpine at a dose of 0.5 mg/kg. Mice were orally treated with 100, 200, and 400 mg/kg extract, and magnitude of fibromyalgia was quantified. In comparison to reserpine group, the extract treatment attenuated pain as shown by significant increase in paw withdrawal threshold against mechanical stimuli (P < 0.05), improved motor ability indicated by increase in fall-off time in inclined plane test (P < 0.05), improved locomotion indicated by increased square crossings in open field test (P < 0.05), and improved cognition as shown by significant reduction in time to reach platform in Morris water maze test and passive avoidance task test (P < 0.05). Extract treatment significantly halted reserpine-induced rise in serum cytokine level (P < 0.05) and brain oxidative stress (P < 0.05). Angelica archangelica extract exerted its beneficial effects in fibromyalgia possibly through the attenuation of oxidative stress-mediated inflammatory cascade. PRACTICAL APPLICATION: Leads from natural products have become an integral part of drug designing processes and have high acceptability due to their better tolerance. The optimization of extraction conditions of plant yields better results and could reduce the processing time, thus increasing its industrial value.