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Japanese Rose (Rosa rugosa) and Immune support: evidence and sources
For educational purposes only, not medical advice. Always consult a qualified practitioner before using medicinal plants, especially alongside prescribed medication, during pregnancy, or for a serious condition.
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Full Japanese Rose monograph →All plants for immune support →
Rose hip, rose hip and seed and rose hip seed, all were negatively monographed by the German Commission E due to insufficient evidence of effects and effectiveness. Therefore a comprehensive review of the literature was conducted to summarize the pharmacological and clinical effects of Rosa canina L. to reevaluate its usefulness in traditional medicine. For various preparations of rose hip and rose hip and seed, antioxidative and antiinflammatory effects have been demonstrated. Lipophilic constituents are involved in those mechanisms of action. The proprietary rose hip and seed powder Litozin has been employed successfully in a number of exploratory studies in patients suffering from osteoarthritis, rheumatoid arthritis and low back pain. However, the sizes of the clinical effects for the different indications need to be determined to assure clinical significance. There is also a rationale behind the use of Litozin as part of a hypocaloric diet based on the rose hip probiotic, stool regulating and smooth muscle-relaxing actions, as well as the rose hip seed lipid-lowering, antiobese and antiulcerogenic effects. Further research is needed to clarify the importance of the reported promising experimental effects in clinical use and to characterize the optimum rose hip seed oil preparation for topical use in the treatment of skin diseases.
3 sources supporting Japanese Rose for Immune support. Includes scientific publications, books, monographs and traditional-use references.
Mechanistic basis
This use is associated with the plant's immunomodulator / immune support action. Further evidence for that pharmacology:
This study elucidates the anti-colorectal cancer (CRC) mechanism of Rosa rugosa cv. Plena polysaccharide RPP1 against AOM/DSS-induced carcinogenesis. Purified via water extraction and chromatography, RPP1 was characterized as an eight-monosaccharide polymer by HPLC. In CRC mice, RPP1 administration reduced colonic polyp formation and ameliorated colon shortening while normalizing elevated serum IL-1β and TNF-α levels. Integrated multi-omics analyses revealed RPP1 remodeled gut microbiota composition through suppression of pro-inflammatory Bacteroides and Desulfovibrio concurrent with enrichment of beneficial Eubacterium and Muribaculum. These microbial shifts were associated with downregulation of fecal phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), perturbing ether lipid, glycerophospholipid and sphingolipid metabolism. Mechanism correlation analysis further indicated Muribaculum/Clostridium modulation mediated RPP1's regulation of LPC levels. Transcriptomics confirmed suppression of lipid-metabolism pathways alongside activation of NOD-like receptor (NLR) and PPAR immune signaling. Collectively, RPP1 alleviates CRC through multifaceted modulation of gut microbiota, lipidomic remodeling, and immune pathway activation.
Rosa damascena and Rosa rugosa , which are the two most commercial species in the Rosa genus, are used to make rose oil, cosmetics, and functional foods. The majority of polysaccharide constituents of both species is structurally diverse and demonstrates promising biological activities, such as moisturizing, immunomodulation, and antioxidant activity. The extraction technique has a significant impact on the yield, purity, and bioactivity of polysaccharides. Traditional extraction methods (hot water, ethanol) are simple and economical, yet they typically produce low yields and degrade sensitive compounds. Novel extraction methods (pressurized liquid extraction, enzyme-assisted extraction, ultrasound-assisted extraction, microwave-assisted extraction, supercritical fluid extraction) offer higher efficiency, selectivity, and sustainability, while better preserving polysaccharide structure and bioactivity. This review serves as a comparative summary of conventional versus novel extraction methodologies of polysaccharides from R. damascena and R. rugosa , with particular consideration towards the yield, polysaccharide structural integrity, sustainability, and industrial conduct of each methodology. In addition, it summarizes the distribution and functional role of selected polysaccharides in the various organs of the plants, while also providing an overview of their antioxidant mechanisms and potential bioactive applications in health. Challenges and critical factors that surround specific species, standards for processes, and extraction methods, and that therefore appeal to time and economic considerations, are identified. In efforts to optimize the extraction methodology, the high economic and functional potential of the Rosa species can be maximized in the interest of healthy, functional consumables for the pharmaceutical, nutraceutical, and cosmetic industries.