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Perforate St John’s-wort (Hypericum perforatum) as a tool for helping with Arthritis / joint pain

Evidence

inferred from anti-inflammatory action

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Hypericum perforatum (St

Natural Standard · 2013

Traditional / referencePerforate St John’s-wortSt John's wortcommon St John's wortperforate St John's wortHypericum perforatum

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St John

Linde, K. et al · 2008

Traditional / referencePerforate St John’s-wortSt John's wortcommon St John's wortperforate St John's wortHypericum perforatum

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2 sources supporting Perforate St John’s-wort for Arthritis / joint pain. Includes scientific publications, books, monographs and traditional-use references.

Mechanistic basis

This use is associated with the plant's anti-inflammatory action. Further evidence for that pharmacology:

Hypericum perforatum L. attenuates depression by regulating Akkermansia muciniphila, tryptophan metabolism and NFkB-NLRP2-Caspase1-IL1beta pathway

Jiang, Z., Wang, F., Zhao, Y., Lu, L., Jiang, X., Huang, T., Lin, Y., Guo, L., Weng, Z. and Liu, E. · Phytomedicine · 2024

PreclinicalPerforate St John’s-wortSt John's wortcommon St John's wortperforate St John's wortHypericum perforatum

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