Symptom → Plant Sources

Meadowsweet (Filipendula ulmaria) and Acid reflux: evidence and sources

Preliminary evidence

inferred from gastroprotective action

For educational purposes only, not medical advice. Always consult a qualified practitioner before using medicinal plants, especially alongside prescribed medication, during pregnancy, or for a serious condition.

← Back to Symptom-to-Plant Lookup

Full Meadowsweet monograph →All plants for acid reflux →

Inhibition of pro-inflammatory biomarkers in THP1 macrophages by polyphenols derived from chamomile, meadowsweet and willow bark

Drummond, E.M., Harbourne, N., Marete, E., Jacquier, J.C., O'Riordan, D. and Gibney, E.R · 2013

Traditional / referenceMeadowsweetmead wortqueen of the meadowFilipendula ulmaria

Find this paper

The Herbal Remedy Handbook

Bridge, J · 2008

Traditional / referenceMeadowsweetmead wortqueen of the meadowFilipendula ulmaria

Find this paper

A Modern Herbal

Grieve, M · 1931

Traditional / referenceBaltic pineChickweedCommon SorrelCommon chickweedDutch clover+43 moreAchillea millefolium

Find this paper

3 sources supporting Meadowsweet for Acid reflux. Includes scientific publications, books, monographs and traditional-use references.

Mechanistic basis

This use is associated with the plant's gastroprotective action. Further evidence for that pharmacology:

Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench

Samardžić, S., Arsenijević, J., Božić, D., Milenković, M. et al. · Journal of Ethnopharmacology · 2017

PreclinicalMeadowsweetmead wortqueen of the meadowFilipendula ulmaria

View source

Ethnopharmacological relevance Meadowsweet (Filipendula ulmaria (L.) Maxim.) and dropwort (Filipendula vulgaris Moench) are herbaceous perennials employed in folk medicine for their antirheumatic, antipyretic and anti-ulcer properties. Aim of the study To assess ethnomedicinal claims through investigation of antioxidant, anti-inflammatory and gastroprotective effects of F. ulmaria and F. vulgaris lyophilized flower infusions (LFIs) as well as the F. vulgaris isolated flavonoids spiraeoside, kaempferol 4'-O-glucoside, astragalin 2'-O-gallate, mixture of hyperoside 2'-O-gallate and isoquercitrin 2'-O-gallate, and a tannin tellimagrandin II. Materials and methods Free radical scavenging activity of the tested samples was determined by examining their ability to neutralize DPPH and OH radicals in vitro, whereas reducing properties were assessed in Ferric Reducing Antioxidant Power (FRAP) assay. Anti-inflammatory activity was studied ex vivo in human platelets by monitoring the effect on eicosanoid biosynthesis. Gastroprotective action was estimated in animal model of acute gastric injury induced by ethanol. Results LFIs and spiraeoside exerted activities comparable to those of positive control in DPPH-radical scavenging and FRAP antioxidant assays, whereas notable hydroxyl radical scavenging ability was demonstrated only for spiraeoside (IC 50 = 5.1μg/mL). Among tested samples, astragalin 2″-O-gallate (IC 50 = 141.1μg/mL) and spiraeoside (IC 50 = 4.69μg/mL) the most markedly inhibited production of pro-inflammatory prostaglandin E 2 and 12(S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid in human platelets, respectively. Examination of LFIs (100-300mg/kg, p.o.) gastroprotective action in rats revealed their capacity to preserve mucosal integrity. In addition, spiraeoside (50mg/kg, p.o.) and tellimagrandin II (40mg/kg, p.o.) showed ulcer preventive ability. Conclusion Current study supports documented traditional use of investigated herbs and indicates that flavonoid and tannin components are partially responsible for the demonstrated pharmacological activities.