Sleep-enhancing effect of Hongcheon-hop (Humulus lupulus L.) extract containing xanthohumol and humulone through GABA-A receptor
Abstract
The bitter resins in hops (Humulus lupulus) modulate GABA receptors, producing sedative effects and enhancing sleep. A hop extract containing xanthohumol and humulone dose-dependently increased sleep duration in a pentobarbital model, enhanced non-rapid-eye-movement (deep delta-wave) sleep, and acted by binding the GABA site on the GABA-A receptor while increasing brain GABA and 5-HT receptor levels, supporting hops as a natural sleep aid.
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How to cite
Lee, H., Chung, S.H., Kwon, D.J., Nam, M.J. et al (2024) 'Sleep-enhancing effect of Hongcheon-hop (Humulus lupulus L.) extract containing xanthohumol and humulone through GABA-A receptor', Journal of Ethnopharmacology, 338(Pt 2), pp. 119019. doi:10.1016/j.jep.2024.119019
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