Chemical composition, skin microbiota metabolism, antimicrobial potential and anti-inflammatory properties of witch hazel bark (Hamamelis virginiana L.)
Abstract
Witch hazel (Hamamelis virginiana) bark, valued in traditional medicine for its astringent tannins, was studied for composition and activity. The aqueous extract and its key component hamamelitannin exhibited the most pronounced anti-inflammatory activity (reducing ROS and cytokine release in human neutrophils and keratinocytes), supported keratinocyte migration in a wound-healing assay and inhibited Staphylococcus aureus growth, supporting its use for skin inflammation and minor wounds.
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How to cite
Skowrońska, W., Pawłowska, K.A., Obrębski, M., Piwowarski, J.P. et al (2025) 'Chemical composition, skin microbiota metabolism, antimicrobial potential and anti-inflammatory properties of witch hazel bark (Hamamelis virginiana L.)', Journal of Ethnopharmacology, 353(Pt B), pp. 120433. doi:10.1016/j.jep.2025.120433
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