Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response
Abstract
Ganoderma lucidum polysaccharides (GLP) down-regulated LPS- or amyloid-beta-induced pro-inflammatory cytokines and promoted anti-inflammatory cytokine expression in microglia, and attenuated inflammation-related microglial migration, morphological alterations and phagocytosis, suggesting the neuroprotective function of reishi polysaccharides is achieved through modulation of microglial inflammatory and behavioural responses.
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How to cite
Cai, Q., Li, Y. and Pei, G (2017) 'Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response', Journal of Neuroinflammation, 14(1), pp. 63. doi:10.1186/s12974-017-0839-0
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