Ganoderma lucidum Polysaccharide Supplementation Significantly Activates T-Cell-Mediated Antitumor Immunity and Enhances Anti-PD-1 Immunotherapy Efficacy in Colorectal Cancer
Abstract
Ganoderma lucidum (reishi) polysaccharide (GLP) significantly inhibited tumor growth and activated antitumor immunity in colorectal cancer: it increased cytotoxic CD8 T cells and Th1 helper cells while decreasing immunosuppressive Tregs, alleviated gut microbiota dysbiosis, increased short-chain fatty acid production, and enhanced the efficacy of anti-PD-1 immunotherapy, supporting reishi as an immunomodulatory prebiotic.
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How to cite
Li, W., Zhou, Q., Lv, B., Li, N. et al (2024) 'Ganoderma lucidum Polysaccharide Supplementation Significantly Activates T-Cell-Mediated Antitumor Immunity and Enhances Anti-PD-1 Immunotherapy Efficacy in Colorectal Cancer', Journal of Agricultural and Food Chemistry, 72(21), pp. 12072-12082. doi:10.1021/acs.jafc.3c08385
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