Omnia SanaFour organosulfur compounds from the seeds of Capsella bursa-pastoris and their anti-inflammatory activities
Abstract
Phytochemical investigation of the seeds of Capsella bursa-pastoris led to the isolation of four organosulfur compounds. There were two new compounds, 10-methylsulfinyl-decanamide ( 1 ) and 11-methylsulfinyl-undecanamide ( 2 ), along with two known compounds ( 3 - 4 ), which all have a sulfoxide group and an amide or a nitrile group. Their chemical structures were elucidated by analysing UV, IR, ESI-MS and NMR spectroscopy. In addition, compounds 1 - 4 were evaluated for their anti-inflammatory activities by using LPS-induced RAW 264.7 cells. Compounds 1 - 4 exhibited potential anti-inflammatory activities on NO release characterised by decreasing the mRNA expression levels of inducible NO synthase (iNOS), cytokines cyclooxygenase-2 (COX-2) and interleukin 6 (IL-6).
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How to cite
Wei, Z.Z., Zhou, T.Q., Xia, Z.M., Liu, S.F. et al (2022) 'Four organosulfur compounds from the seeds of Capsella bursa-pastoris and their anti-inflammatory activities', Natural Product Research, 37(16), pp. 2688-2696. doi:10.1080/14786419.2022.2130307
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