Vasorelaxant effects of the Vitex agnus-castus extract

Tha\c ci, S. and Krasniqi, B. and D\"ermaku-Sopjani, M. and Rifati-Nixha, A. and Abazi, S. and Sopjani, M. · Evidence-Based Complementary and Alternative Medicine · 2022

Preclinical

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Abstract

This study was undertaken to describe and characterize the relaxing effects of Vitex agnus-castus (VAC) extract on isolated rabbit arterial rings. The cumulative addition of VACE (0.15-0.75 mg/mL) relaxed, in a concentration-dependent manner, the rabbit aorta rings precontracted either with phenylephrine or with high KCl, suggesting calcium channel blocking activities. The VACE effect appeared to be endothelium-dependent. Preincubation with L-NAME, ODQ and indomethacin downregulated VACE-induced relaxation, whereas bradykinin and zaprinast further upregulated it. These results revealed that the aorta relaxation effect of VACE was mainly endothelium-dependent and mediated by NO/cGMP and prostaglandins synthesis.

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How to cite

Tha\c ci, S. and Krasniqi, B. and D\"ermaku-Sopjani, M. and Rifati-Nixha, A. and Abazi, S. and Sopjani, M (2022) 'Vasorelaxant effects of the Vitex agnus-castus extract', Evidence-Based Complementary and Alternative Medicine, 2022, pp. 7708781. doi:10.1155/2022/7708781

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