The effects of Vitex agnus-castus on menstrual bleeding: a systematic review and meta-analysis

Abstract

This systematic review examined the evidence of the effectiveness and safety of Vitex on menstrual bleeding and its side effects. Out of 8,905 searched papers, five papers entered this study. Based on the subgroup analysis, the consumption of Vitex did not have a significant effect on the amount of menstrual bleeding compared to the placebo group in the first (mean difference 3.08; 95% CI -3.11 to 9.26; p=0.33) and second menstrual cycles (MD 0.00; 95% CI -5.75 to 5.75; p=1.00). The Higham mean score was statistically higher in the Vitex group compared to the mefenamic acid group in the first menstrual cycle (MD 7.17; 95% CI 0.33-14.01; p=0.04) but there was no significant difference in the second cycle. Only nausea and abdominal pain were reported as side effects. The results showed that the consumption of Vitex did not have a significant effect on menstrual bleeding in comparison with placebo.