Omnia SanaEfficacy and safety of Rosa canina L. and a traditional polyherbal formulation syrup in children and adolescents with attention-deficit/hyperactivity disorder: a factorial randomized double-blind placebo-controlled clinical trial
Abstract
The present study was conducted to determine the efficacy and safety of Rosa canina L. and a traditional polyherbal formulation (PHF) syrup on ADHD as a complementary treatment. Ninety ADHD patients aged 5-14 years based on DSM-5 diagnostic criteria were randomly divided into three groups to receive (1) R. canina syrup + methylphenidate (MPH), (2) PHF syrup + MPH, and (3) placebo syrup + MPH for 8 weeks. The results showed that the decreasing trend of intra-group changes in the sum of CTRS, CPRS, and CSI-4 was statistically significant in three groups. The study of intergroup changes in the CTRS (p = 0.02) and CSI-4 (p = 0.04) was significant and the CPRS was not significant (p = 0.15). Therefore, R. canina and PHF syrups in combination with standard medical treatment could provide more clinical benefits for ADHD patients.
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How to cite
Golsorkhi, H. and Montazerlotfelahi, H. and Abniki, E. and Vafaee-Shahi, M. and Kamalinejad, M. and Qorbani, M. and Bahrami, M. and Dadmehr, M (2025) 'Efficacy and safety of Rosa canina L. and a traditional polyherbal formulation syrup in children and adolescents with attention-deficit/hyperactivity disorder: a factorial randomized double-blind placebo-controlled clinical trial', Phytotherapy Research, 39(9), pp. 4116--4125. doi:10.1002/ptr.70061
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