Two new triterpenoid glycosides from Bacopa monnieri and their cytotoxic activity

Abstract

Using combined chromatographic methods, two new triterpenoid glycosides, bacopasaponin K ( 1 ) and bacopasaponin L ( 2) , along with eight known compounds, bacopaside IV ( 3 ), bacopaside VII ( 4 ), bacopasaponin E ( 5 ), bacoside A 3 ( 6 ), bacopasaponin F ( 7 ), bacopasaponin C ( 8 ), bacopaside I ( 9 ), and bacopaside II ( 10 ) were isolated from the methanol extract of the Bacopa monnieri . Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis, HR-ESI-MS and comparing with the NMR data reported in the literature. All these compounds were evaluated for their cytotoxic activity using the cell counting kit-8 (CCK-8) assay. Compounds 4 , 6 , 8 , and 10 exhibited potential cytotoxic effects against human lung cancer cells (PC9) and human colon cancer cells (SW620).