Comparison of protective and curative potential of Daucus carota root extract on renal ischemia reperfusion injury in rats

Abstract

Context Daucus carota Linn (Apiaceae), a useful vegetable, is traditionally used in treating kidney and hepatic dysfunctions. Objective To evaluate the protective and curative potential of D. carota root extract on renal ischemia reperfusion injury in rats. Materials and methods Wistar rats were selected with 8 + 8 groups (n = 6). Renal pedicles of rats were occluded for 45 min and allowed for reperfusion period. In protective and curative studies, 14 days prior and 14 days after the induction of ischemia/reperfusion (I/R), rats received petroleum ether extract (PEE 250 and 500 mg/kg), fractional methanol extract (FME 250 and 500 mg/kg) and direct methanol extract (DME 250 and 500 mg/kg) of Daucus carota root, orally, once daily. Results PEE at a dose of 500 mg/kg significantly (p Discussion and conclusion Findings demonstrate that postconditioning with the D. carota root extract significantly improves kidney function in I/R rats.