Antihyperglycemic and Antihyperlipidemic Effects of Lippia citriodora in Rats

Abstract

Aim The study was conducted to assess the antidiabetic and antihyperlipidemic effects of Lippia citriodora. Background Lippia citriodora Kunth (Verbenaceae) is a medicinal plant with many traditional uses. Objective The goal of this study was to investigate the antidiabetic activity of aqueous extract of Lippia citriodora and its capacity to improve the lipid profile in diabetic rats. Methods Normal and diabetic rats were treated orally for 15 days by the leaves aqueous extract of Lippia citriodora (LCLAE) (100 mg/kg). The whole glucose utilization and liver architecture were also evaluated. The in vitro antioxidant activity of LCLAE was also assessed. Results LCLAE lowered blood glucose and lipid levels in all groups. Moreover, LCLAE ameliorated the liver structure and exhibited antioxidant activity. Conclusion In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of LCLAE in rats.