Omnia SanaHypoglycemic effect of Coffea arabica leaf extracts and major bioactive constituents
Abstract
The present study focused on investigating the antioxidant, antiglycation activity, digestive enzymes inhibition, bioaccessibility and hypoglycemic effect of C. arabica leaves extracts. The extracts deactivated the O 2 • - , ROO•, H 2 O 2 , HOCl reactive oxygen species. Coffee leaves showed strong inhibition of α-glucosidase (IC 50 = 40.30 μg mL -1 ) greater than the isolated metabolites and acarbose. There was also inhibition of pancreatic lipase (IC 50 = 56.43 μg mL -1 ) in addition to a hypoglycemic effect in zebrafish similar to acarbose and metformin. With the exception of rutin, all biocompounds were detected at all stages of in vitro digestion. Finally, these results suggest that C. arabica leaf extracts possess antidiabetic and anti-obesity properties that can be attributed to the main metabolites and the synergistic action between them.Communicated by Ramaswamy H. Sarma.
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How to cite
Nascimento, G.O. and Marques, S.P.D. and Maia, C.E.G. and de Sousa, A.F. and Cunha, R.L. and Malta, M.R. and Owen, R.W. and Ferreira, M.K.A. and da Silva, A.W. and Reboucas, E.L. and de Menezes, J.E.S.A. and Marinho, M.M. and Marinho, E.S. and Dos Santos, H.S. and Saliba, A.S.M.C. and Massarioli, A.P. and Alencar, S.M. and Sartori, A.G.O. and Trevisan, M.T.S (2023) 'Hypoglycemic effect of Coffea arabica leaf extracts and major bioactive constituents', Journal of Biomolecular Structure & Dynamics, 41(24), pp. 14871-14886. doi:10.1080/07391102.2023.2188421
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