Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity

Cha, J.M., Suh, W.S., Lee, T.H., Subedi, L., Kim, S.Y. and Lee, K.R. · Molecules · 2017

Preclinical

Abstract

A new sesquilignan glycoside 1 , together with seven known phenolic glycosides 2 - 8 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR) data (¹H- and 13 C-NMR, ¹H-¹H correlation spectroscopy (¹H-¹H COSY), heteronuclear single-quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear overhauser effect spectroscopy (NOESY)) and HR-FABMS analysis. The anti-inflammatory effects of 1 - 8 were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds 4 and 7 exhibited moderate inhibitory effects on nitric oxide production in LPS-activated BV-2 cells, with IC 50 values of 17.80 and 27.91 µM, respectively.

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How to cite

Cha, J.M., Suh, W.S., Lee, T.H., Subedi, L., Kim, S.Y. and Lee, K.R (2017) 'Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity', Molecules, 22(6), pp. 1023. doi:10.3390/molecules22061023

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