Omnia SanaHibiscus sabdariffa extract lowers blood pressure and improves endothelial function
Abstract
Polyphenols from Hibiscus sabdariffa calices were administered to patients with metabolic syndrome (125 mg/kg/day for 4 wk, n = 31) and spontaneously hypertensive rats (125 or 60 mg/kg in a single dose or daily for 1 wk, n = 8 for each experimental group). The H. sabdariffa extract improved metabolism, displayed potent anti-inflammatory and antioxidant activities, and significantly reduced blood pressure in both humans and rats. Diuresis and inhibition of the angiotensin I-converting enzyme were found to be less important mechanisms than those related to the antioxidant, anti-inflammatory, and endothelium-dependent effects to explain the beneficial actions. Notably, polyphenols induced a favorable endothelial response that should be considered in the management of metabolic cardiovascular risks.
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How to cite
Joven, J., March, I., Espinel, E., Fernandez-Arroyo, S., Rodriguez-Gallego, E., Aragones, G., Beltran-Debon, R., Alonso-Villaverde, C., Rios, L., Martin-Paredero, V., Menendez, J.A., Micol, V., Segura-Carretero, A. and Camps, J (2014) 'Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function', Molecular Nutrition & Food Research, 58(6), pp. 1374-1378. doi:10.1002/mnfr.201300774
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