Omnia SanaLamiridosins, hepatitis C virus entry inhibitors from Lamium album
Abstract
Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC(50) 2.31 muM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.
Referenced for these plants
How to cite
Zhang, H., Rothwangl, K., Mesecar, A.D., Sabahi, A., Rong, L. and Fong, H.H.S (2009) 'Lamiridosins, hepatitis C virus entry inhibitors from Lamium album', Journal of Natural Products, 72(12), pp. 2158-2162. doi:10.1021/np900549e
This reference is part of the evidence base for the Omnia Sana plant database. Source links open the original publication; Omnia Sana does not host third-party content.