Nature, properties and the mechanism of the effect on blood coagulation of the preparation obtained from Pulmonaria officinalis

Abstract

The non-dialyzable fraction of the ammonia extract from Pulmonaria officinalis contains the anticoagulant glycopeptide. The anticoagulant in doses reducing total coagulation activity of the blood 4-5-fold, does not change the animals' behaviour, hypocoagulemia remains at a high level up to 6 h after intravenous administration of the anticoagulant, and diminishes only after 24 h. The anticoagulant reduces the death rate of the animals with exogenous thromboplastinemia by suppressing the blood coagulation activity. The inhibitor effect is realized mainly at the stage of fibrinogen conversions.