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Development of a PBPK model of psilocybin/psilocin from Psilocybe cubensis (magic mushroom) in mice, rats, and humans

Thaoboonruang, N., Lohitnavy, O., Ya, K. and Lohitnavy, M. · Scientific Reports · 2025

Preclinical

Abstract

A physiologically based pharmacokinetic (PBPK) model of psilocybin/psilocin from the magic mushroom Psilocybe cubensis was developed across mice, rats and humans, characterising the disposition of the mushroom's active alkaloids.

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How to cite

Thaoboonruang, N., Lohitnavy, O., Ya, K. and Lohitnavy, M (2025) 'Development of a PBPK model of psilocybin/psilocin from Psilocybe cubensis (magic mushroom) in mice, rats, and humans', Scientific Reports, 15(1), pp. 13721. doi:10.1038/s41598-025-98202-w

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