Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
Abstract
In the COSMOS randomized clinical trial, cocoa (Theobroma cacao) flavanol supplementation did not significantly reduce total cardiovascular events but reduced cardiovascular mortality in secondary analyses, providing the largest trial evidence on cocoa flavanols and cardiovascular health.
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How to cite
Sesso, H.D., Manson, J.E., Aragaki, A.K., Rist, P.M. and others (2022) 'Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial', The American Journal of Clinical Nutrition, 115(6), pp. 1490-1500. doi:10.1093/ajcn/nqac055
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