Detoxification of comfrey (Symphytum officinale L.) extract using natural deep eutectic solvent (NADES) and evaluation of its anti-inflammatory, antioxidant, and hepatoprotective properties
Abstract
Natural deep eutectic solvents (betaine-urea) selectively extracted the anti-inflammatory, antioxidant constituent rosmarinic acid over the hepatotoxic pyrrolizidine alkaloid lycopsamine from comfrey (Symphytum officinale), giving extracts with higher anti-inflammatory and antioxidant and lower hepatotoxic profiles — a detoxification approach for medicinal comfrey.
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How to cite
Syarifah, A.N., Suryadi, H., Hayun, H., Simamora, A. and others (2023) 'Detoxification of comfrey (Symphytum officinale L.) extract using natural deep eutectic solvent (NADES) and evaluation of its anti-inflammatory, antioxidant, and hepatoprotective properties', Frontiers in Pharmacology, 14, pp. 1012716. doi:10.3389/fphar.2023.1012716
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