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Ethanolic Extract of Rosa rugosa Roots and Its Bioactive Compound, Oleamide, Prevented Amyloid beta-Induced Oxidative Stress and Improved Behavioral Tests in Mice

Park, C.K., Choi, S.J., Kim, C.R., Shin, H.R. and others · International Journal of Molecular Sciences · 2025

Preclinical

Abstract

Rosa rugosa root extract and its bioactive compound oleamide protected against amyloid-beta-induced neurotoxicity in mice, improving cognition in Y-maze and passive-avoidance tests, restoring acetylcholine and reducing malondialdehyde, indicating antioxidant and neuroprotective effects.

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How to cite

Park, C.K., Choi, S.J., Kim, C.R., Shin, H.R. and others (2025) 'Ethanolic Extract of Rosa rugosa Roots and Its Bioactive Compound, Oleamide, Prevented Amyloid beta-Induced Oxidative Stress and Improved Behavioral Tests in Mice', International Journal of Molecular Sciences, 26(9), pp. 4214. doi:10.3390/ijms26094214

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