Plant Comparison
Soapwort vs Heartsease
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Soapwort and Heartsease: they share 5 indicated uses (bronchitis, cough, eczema, …); 1 pharmacological action in common.
Evidence face-off — shared uses
| Condition | Soapwort | Heartsease | Verdict |
|---|---|---|---|
| Bronchitis | 1/10 | 1/10 | Comparable evidence |
| Cough | 1/10 | 1/10 | Comparable evidence |
| Eczema | 2/10 | 3/10 | Comparable evidence |
| Respiratory support | 1/10 | 1/10 | Comparable evidence |
| Skin irritation | 2/10 | 1/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Surfactant compounds giving the soapy, expectorant and irritant properties; their surface activity has been confirmed experimentally, with Saponaria officinalis saponins forming stable oil-in-water nanoemulsions.
Bioactive cyclic peptides shown to suppress over-active immune (T-cell) responses - the rationale for use in inflammatory skin disease; the cytotoxic cyclotides vitri A, varv A and varv E have been isolated from V. tricolor. Cyclotide-enriched preparations (including hot-water decoctions) reduce T-cell proliferation and macrophage cytokine output in vitro, of interest for inflammatory bowel disease.
Pharmacological Actions
Anti-inflammatory / immunomodulatory for chronic skin conditions - eczema, psoriasis, itching and scabs (traditional, supported by cyclotide research) - cyclotide-enriched V. tricolor preparations suppress T-cell proliferation and pro-inflammatory cytokine secretion in vitro; Soothes irritated skin (demulcent and anti-inflammatory)
Cytotoxic / antiproliferative against cancer cell lines in vitro (cyclotides vitri A, varv A and varv E)
Soothes irritated skin (demulcent and anti-inflammatory); Traditional demulcent / expectorant for cough, bronchitis and chest inflammation
Traditional demulcent / expectorant for cough, bronchitis and chest inflammation
Anti-inflammatory / immunomodulatory for chronic skin conditions - eczema, psoriasis, itching and scabs (traditional, supported by cyclotide research) - cyclotide-enriched V. tricolor preparations suppress T-cell proliferation and pro-inflammatory cytokine secretion in vitro
Traditional & Indicated Uses
Expectorant for cough, bronchitis and upper-respiratory catarrh (saponins stimulate the cough reflex and loosen mucus) - largely an outdated use
Expectorant for cough, bronchitis and upper-respiratory catarrh (saponins stimulate the cough reflex and loosen mucus) - largely an outdated use
Topical cleansing/soothing for skin ailments (the saponins act as a natural soap; traditional for eczema)
Topical cleansing/soothing for skin ailments (the saponins act as a natural soap; traditional for eczema)
Expectorant for cough, bronchitis and upper-respiratory catarrh (saponins stimulate the cough reflex and loosen mucus) - largely an outdated use
inferred from anti-inflammatory action
Traditional demulcent / expectorant for cough, bronchitis and chest inflammation
inferred from anticancer action
Traditional demulcent / expectorant for cough, bronchitis and chest inflammation
Anti-inflammatory / immunomodulatory for chronic skin conditions - eczema, psoriasis, itching and scabs (traditional, supported by cyclotide research) - cyclotide-enriched V. tricolor preparations suppress T-cell proliferation and pro-inflammatory cytokine secretion in vitro
inferred from immunomodulator action
Traditional demulcent / expectorant for cough, bronchitis and chest inflammation
Anti-inflammatory / immunomodulatory for chronic skin conditions - eczema, psoriasis, itching and scabs (traditional, supported by cyclotide research) - cyclotide-enriched V. tricolor preparations suppress T-cell proliferation and pro-inflammatory cytokine secretion in vitro
inferred from expectorant action
Soothes irritated skin (demulcent and anti-inflammatory)
Safety, Cautions & Contraindications
SERIOUS: the saponins are irritant and can cause haemolysis (destruction of red blood cells). Never take soapwort in large doses or for prolonged periods. Internal use can cause severe gastrointestinal irritation (cramps, nausea, vomiting, diarrhoea).
Internal use should only be under professional supervision; its expectorant use is now largely outdated. Avoid in pregnancy and breastfeeding.
Regarded as safe in customary traditional use; because the extract suppresses immune-cell activity, there is a theoretical caution when taking immunosuppressant medicines.
Contains salicylates, so use caution if you are salicylate-sensitive; safety in pregnancy and breastfeeding is not established.
External Ids
Botanical Description
Perennial herb (Caryophyllaceae), 30-90 cm tall, with erect, smooth or slightly hairy stems. Leaves are opposite, elliptical to lance-shaped, with 3-5 prominent veins. Clusters of fragrant, pale pink to white, five-petalled flowers are borne at the stem tips. The root system is creeping and rhizomatous.[12]
Small, low-growing annual or short-lived perennial herb with oval to lance-shaped, scalloped leaves and large, leaf-like stipules. The distinctive flowers are tricoloured - purple, yellow and white in varying combinations - with five petals, the lower petal often marked with dark veining (a 'face' pattern), giving rise to the name 'heartsease'.[9]
Habitat
Native to Europe and western Asia and widely naturalised elsewhere; grows on riverbanks, roadsides, waste ground and damp meadows, often near old settlements, reflecting its historic cultivation as a source of soap.[12]
Grows in grassland, cultivated ground, gardens and waste places on a wide range of soils; native to Europe and widely naturalised elsewhere as a common garden and wild plant.[9]
Harvesting
The root is dug in autumn (traditionally from 2-3-year-old plants), when saponin content is highest; aerial parts are cut during the growing season.[12]
The flowering aerial parts are cut in summer while in flower and dried in a warm, shaded, airy place.[9]
Traditional Uses
Soapwort takes its name from its traditional use as a natural, gentle soap - the root, crushed and agitated in water, produces a lathering saponin solution historically used for washing delicate fabrics and, topically, for skin conditions like eczema. Internal use as an expectorant for cough is an older tradition now considered outdated given the irritant, haemolytic risk of concentrated saponins.[11, 12]
Heartsease has a long European folk history as a soothing remedy for skin conditions such as eczema and itching, and as a traditional demulcent and expectorant for coughs and chest complaints; this traditional skin-supportive use is now linked to immunomodulatory cyclic peptides (cyclotides) unique to the Viola genus.[9]
Preparations
Crushed root simmered in water to produce a lathering, gentle cleansing wash for skin and delicate textiles.
Dried aerial parts or diluted root steeped in hot water; internal use only under professional supervision given real toxicity risk.
Dried flowering herb infused in hot water, taken internally for cough or used as a cooled compress for skin irritation.
Dosage
Given the real risk of haemolysis and gastrointestinal irritation from concentrated saponins, internal use should only be undertaken under professional supervision, at low doses and for short periods; topical/external use as a wash is the safer traditional application. Educational reference only, not a prescription; never take in large or prolonged doses.
The EU herbal monograph gives, for oral use in adults and elderly, 3 g of the comminuted herb as an infusion 1-3 times daily. For cutaneous use, 5-20 g/L as an infusion applied as a wet dressing 2-3 times daily, or 5-10 g/L as a bath additive (1 litre of infusion per bath). Contraindicated in hypersensitivity to salicylates, and cutaneously on open wounds or large areas of damaged skin. Oral use not recommended under 18 years. Educational reference only, not a prescription.
References
Lookalikes Review
References & Sources
- Grzywaczyk, A., Smulek, W. and Kaczorek, E (2024) 'Saponaria officinalis saponins as a factor increasing permeability of Candida yeasts' biomembrane', World Journal of Microbiology & Biotechnology, 40(5), pp. 152. doi:10.1007/s11274-024-03961-9 Preclinical
https://doi.org/10.1007/s11274-024-03961-9 - Smulek, W., Zdarta, A., Pacholak, A., Zgola-Grzeskowiak, A. and others (2016) 'Saponaria officinalis L. extract: Surface active properties and impact on environmental bacterial strains', Colloids and Surfaces B: Biointerfaces, 150, pp. 209-215. doi:10.1016/j.colsurfb.2016.11.035 Preclinical
https://doi.org/10.1016/j.colsurfb.2016.11.035 - Jurek, I., Szuplewska, A., Chudy, M. and Wojciechowski, K (2021) 'Soapwort (Saponaria officinalis L.) Extract vs. Synthetic Surfactants - Effect on Skin-Mimetic Models', Molecules, 26(18), pp. 5628. doi:10.3390/molecules26185628 Preclinical
https://doi.org/10.3390/molecules26185628 - Yu, G.R., Lim, D.W., Karunarathne, W.A.H.M., Kim, G.Y. and others (2022) 'A non-polar fraction of Saponaria officinalis L. acted as a TLR4/MD2 complex antagonist and inhibited TLR4/MyD88 signaling in vitro and in vivo', FASEB Journal, 36(7), pp. e22387. doi:10.1096/fj.202200018RR Preclinical
https://doi.org/10.1096/fj.202200018RR - Hedayati, A., Naseri, F., Nourozi, E., Hosseini, B. and others (2022) 'Response of Saponaria officinalis L. hairy roots to the application of TiO2 nanoparticles in terms of production of valuable polyphenolic compounds and SO6 protein', Plant Physiology and Biochemistry, 178, pp. 80-92. doi:10.1016/j.plaphy.2022.03.001 Preclinical
https://doi.org/10.1016/j.plaphy.2022.03.001 - Sefrioui, M.R., El Othmani, I.S., Filali, H., Derfoufi, S. and others (2021) 'Evaluation of spermicidal activity of saponosides from Saponaria officinalis (Caryophyllaceae), Glycyrrhiza glabra (Fabaceae) and Herniaria glabra (Caryophyllaceae)', Medicine and Pharmacy Reports, 94(2), pp. 239-247. doi:10.15386/mpr-1879 Preclinical
https://doi.org/10.15386/mpr-1879 - Petrovic, G.M., Ilic, M.D., Stankov-Jovanovic, V.P., Stojanovic, G.S. and Jovanovic, S.C (2017) 'Phytochemical analysis of Saponaria officinalis L. shoots and flowers essential oils', Natural Product Research, 32(3), pp. 331-334. doi:10.1080/14786419.2017.1350668 Preclinical
https://doi.org/10.1080/14786419.2017.1350668 - Ashurova, L.N., Khurramov, A.R., Bobakulov, K.M., Sasmakov, S.A. and others (2025) 'A new withanolide from Saponaria officinalis and its antimicrobial and cytotoxic activities', Natural Product Research, 40(9), pp. 2392-2401. doi:10.1080/14786419.2025.2472276 Preclinical
https://doi.org/10.1080/14786419.2025.2472276 - Bolshakov, A.P., Stepanichev, M.Y., Dobryakova, Y.V., Spivak, Y.S. and Markevich, V.A (2020) 'Saporin from Saponaria officinalis as a Tool for Experimental Research, Modeling, and Therapy in Neuroscience', Toxins (Basel), 12(9), pp. 546. doi:10.3390/toxins12090546 Traditional / reference
https://doi.org/10.3390/toxins12090546 - Nujkic, M., Milic, S., Spalovic, B., Dardas, A. and others (2020) 'Saponaria officinalis L. and Achillea millefolium L. as possible indicators of trace elements pollution caused by mining and metallurgical activities in Bor, Serbia', Environmental Science and Pollution Research International, 27(36), pp. 44969-44982. doi:10.1007/s11356-020-10371-5 Preclinical
https://doi.org/10.1007/s11356-020-10371-5 - Drugs.com (n.d.) 'Soapwort Uses, Benefits & Dosage'. Available at: https://www.drugs.com/npp/soapwort.html Traditional / reference
https://www.drugs.com/npp/soapwort.html - MedicineNet (n.d.) 'Soapwort Root: Eczema Uses, Benefits, Side Effects'. Available at: https://www.medicinenet.com/soapwort/article.htm Traditional / reference
https://www.medicinenet.com/soapwort/article.htm - Jarzebski, M., Siejak, P., Smulek, W., Fathordoobady, F., Guo, Y. and others (2020) 'Plant Extracts Containing Saponins Affects the Stability and Biological Activity of Hempseed Oil Emulsion System', Molecules, 25(11). doi:10.3390/molecules25112696 Preclinical
https://doi.org/10.3390/molecules25112696
- Retzl, B., Zimmermann-Klemd, A.M., Winker, M., Nicolay, S., Grundemann, C. and Gruber, C.W (2023) 'Exploring Immune Modulatory Effects of Cyclotide-Enriched Viola tricolor Preparations', Planta Medica, 89(15), pp. 1493--1504. doi:10.1055/a-2173-8627 Preclinical
https://doi.org/10.1055/a-2173-8627 - Harati, E., Bahrami, M., Razavi, A., Kamalinejad, M. and others (2018) 'Effects of Viola tricolor Flower Hydroethanolic Extract on Lung Inflammation in a Mouse Model of Chronic Asthma', Iranian Journal of Allergy, Asthma, and Immunology, 17(5), pp. 409-417. doi:10.18502/ijaai.v17i5.299 Preclinical
https://doi.org/10.18502/ijaai.v17i5.299 - Sadeghnia, H.R., Ghorbani Hesari, T., Mortazavian, S.M., Mousavi, S.H. and others (2014) 'Viola tricolor induces apoptosis in cancer cells and exhibits antiangiogenic activity on chicken chorioallantoic membrane', BioMed Research International, 2014, pp. 625792. doi:10.1155/2014/625792 Preclinical
https://doi.org/10.1155/2014/625792 - Mousavi, S.H., Naghizade, B., Pourgonabadi, S. and Ghorbani, A (2016) 'Protective effect of Viola tricolor and Viola odorata extracts on serum/glucose deprivation-induced neurotoxicity: role of reactive oxygen species', Avicenna Journal of Phytomedicine, 6(4), pp. 434-441. Preclinical
https://scholar.google.com/scholar?q=Protective%20effect%20of%20Viola%20tricolor%20and%20Viola%20odorata%20extracts%20on%20serum/glucose%20deprivation-induced%20neurotoxicity%3A%20role%20of%20reactive%20oxygen%20species - Witkowska-Banaszczak, E., Bylka, W., Matlawska, I., Goslinska, O. and Muszynski, Z (2005) 'Antimicrobial activity of Viola tricolor herb', Fitoterapia, 76(5), pp. 458-461. doi:10.1016/j.fitote.2005.03.005 Preclinical
https://doi.org/10.1016/j.fitote.2005.03.005 - Baradaran Rahimi, V., Askari, V.R., Hosseini, M., Yousefsani, B.S. and Sadeghnia, H.R (2019) 'Anticonvulsant Activity of Viola tricolor against Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice', Iranian Journal of Medical Sciences, 44(3), pp. 220-226. Preclinical
https://scholar.google.com/scholar?q=Anticonvulsant%20Activity%20of%20Viola%20tricolor%20against%20Seizures%20Induced%20by%20Pentylenetetrazol%20and%20Maximal%20Electroshock%20in%20Mice - Piana, M., Silva, M.A., Trevisan, G., de Brum, T.F. and others (2013) 'Antiinflammatory effects of Viola tricolor gel in a model of sunburn in rats and the gel stability study', Journal of Ethnopharmacology, 150(2), pp. 458-465. doi:10.1016/j.jep.2013.08.040 Preclinical
https://doi.org/10.1016/j.jep.2013.08.040 - Han, B.Y., Wang, Z.L., Li, J., Jin, Q. and others (2023) 'A highly selective C-rhamnosyltransferase from Viola tricolor and insights into its mechanisms', Acta Pharmaceutica Sinica B, 13(8), pp. 3535-3544. doi:10.1016/j.apsb.2023.05.011 Preclinical
https://doi.org/10.1016/j.apsb.2023.05.011 - Hellinger, R., Koehbach, J., Fedchuk, H., Sauer, B., Huber, R., Gruber, C.W. and Grundemann, C (2013) 'Immunosuppressive activity of an aqueous Viola tricolor herbal extract', Journal of Ethnopharmacology, pp. 2013. doi:10.1016/j.jep.2013.10.044 Traditional / reference
https://doi.org/10.1016/j.jep.2013.10.044 - Kirichenko, T.V., Sobenin, I.A., Nikolic, D., Rizzo, M. and Orekhov, A.N (2015) 'Anti-cytokine therapy for prevention of atherosclerosis', Phytomedicine, 23(11), pp. 1198-1210. doi:10.1016/j.phymed.2015.12.002 Clinical study
https://doi.org/10.1016/j.phymed.2015.12.002 - Conzelmann, C., Muratspahic, E., Tomasevic, N., Munch, J. and Gruber, C.W (2022) 'Inhibition of HIV-1 by Cyclotide-Enriched Extracts of Viola tricolor', Frontiers in Pharmacology, 13, pp. 888961. doi:10.3389/fphar.2022.888961 Preclinical
https://doi.org/10.3389/fphar.2022.888961 - Maraschio, A., Wulhfard, K. and Monsellato, L (2023) 'Case study of clinical improvement of atopic dermatitis in a patient treated with herbal-based parapharmaceuticals', Journal of Complementary & Integrative Medicine, 20(2), pp. 504-511. doi:10.1515/jcim-2023-0005 Clinical study
https://doi.org/10.1515/jcim-2023-0005 - Svangard, E. and Goransson, U. and Hocaoglu, Z. and Gullbo, J. and Larsson, R. and Claeson, P. and Bohlin, L (2004) 'Cytotoxic cyclotides from Viola tricolor', Journal of Natural Products, 67(2), pp. 144--147. doi:10.1021/np030101l Preclinical
https://doi.org/10.1021/np030101l - European Medicines Agency (HMPC) (2010) 'Community herbal monograph on Viola tricolor L. and/or subspecies Viola arvensis Murray (Gaud) and Viola vulgaris Koch (Oborny), herba cum flore'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-viola-tricolor-l_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-viola-tricolor-l_en.pdf
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.