Plant Comparison
Sweet Violet vs Heartsease
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Sweet Violet and Heartsease: both belong to the Violaceae family; they share 8 indicated uses (arthritis / joint pain, bronchitis, cancer (anticancer research), …); 4 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Sweet Violet | Heartsease | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 1/10 | 2/10 | Comparable evidence |
| Bronchitis | 5/10 | 1/10 | Stronger for Sweet Violet |
| Cancer (anticancer research) | 2/10 | 2/10 | Comparable evidence |
| Cough | 5/10 | 1/10 | Stronger for Sweet Violet |
| Inflammation (general) | 1/10 | 3/10 | Stronger for Heartsease |
| Respiratory support | 6/10 | 1/10 | Stronger for Sweet Violet |
| Skin irritation | 5/10 | 1/10 | Stronger for Sweet Violet |
| Sore throat | 1/10 | 1/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Bioactive cyclic peptides shown to suppress over-active immune (T-cell) responses - the rationale for use in inflammatory skin disease; the cytotoxic cyclotides vitri A, varv A and varv E have been isolated from V. tricolor. Cyclotide-enriched preparations (including hot-water decoctions) reduce T-cell proliferation and macrophage cytokine output in vitro, of interest for inflammatory bowel disease.
Pharmacological Actions
Demulcent / expectorant for cough, bronchitis and catarrh (mucilage soothes; saponins loosen mucus) - a double-blind RCT found violet-flower syrup, added to standard treatment, sped cough suppression in children with asthma
Demulcent / expectorant for cough, bronchitis and catarrh (mucilage soothes; saponins loosen mucus) - a double-blind RCT found violet-flower syrup, added to standard treatment, sped cough suppression in children with asthma
Anti-inflammatory / immunomodulatory for chronic skin conditions - eczema, psoriasis, itching and scabs (traditional, supported by cyclotide research) - cyclotide-enriched V. tricolor preparations suppress T-cell proliferation and pro-inflammatory cytokine secretion in vitro; Soothes irritated skin (demulcent and anti-inflammatory)
Cytotoxic / antiproliferative against cancer cell lines in vitro (cyclotides vitri A, varv A and varv E)
Soothes irritated skin (demulcent and anti-inflammatory); Traditional demulcent / expectorant for cough, bronchitis and chest inflammation
Traditional demulcent / expectorant for cough, bronchitis and chest inflammation
Anti-inflammatory / immunomodulatory for chronic skin conditions - eczema, psoriasis, itching and scabs (traditional, supported by cyclotide research) - cyclotide-enriched V. tricolor preparations suppress T-cell proliferation and pro-inflammatory cytokine secretion in vitro
Traditional & Indicated Uses
inferred from anti-inflammatory action
Demulcent / expectorant for cough, bronchitis and catarrh (mucilage soothes; saponins loosen mucus) - a double-blind RCT found violet-flower syrup, added to standard treatment, sped cough suppression in children with asthma
Demulcent / expectorant for cough, bronchitis and catarrh (mucilage soothes; saponins loosen mucus) - a double-blind RCT found violet-flower syrup, added to standard treatment, sped cough suppression in children with asthma
inferred from anticancer action
Demulcent / expectorant for cough, bronchitis and catarrh (mucilage soothes; saponins loosen mucus) - a double-blind RCT found violet-flower syrup, added to standard treatment, sped cough suppression in children with asthma
Mild sedative for sleeplessness and to ease headache (traditional)
inferred from anti-inflammatory action
Mild sedative for sleeplessness and to ease headache (traditional)
inferred from expectorant action
inferred from demulcent action
inferred from anti-inflammatory action
Traditional demulcent / expectorant for cough, bronchitis and chest inflammation
inferred from anticancer action
Traditional demulcent / expectorant for cough, bronchitis and chest inflammation
Anti-inflammatory / immunomodulatory for chronic skin conditions - eczema, psoriasis, itching and scabs (traditional, supported by cyclotide research) - cyclotide-enriched V. tricolor preparations suppress T-cell proliferation and pro-inflammatory cytokine secretion in vitro
inferred from immunomodulator action
Traditional demulcent / expectorant for cough, bronchitis and chest inflammation
Anti-inflammatory / immunomodulatory for chronic skin conditions - eczema, psoriasis, itching and scabs (traditional, supported by cyclotide research) - cyclotide-enriched V. tricolor preparations suppress T-cell proliferation and pro-inflammatory cytokine secretion in vitro
inferred from expectorant action
Soothes irritated skin (demulcent and anti-inflammatory)
Safety, Cautions & Contraindications
Generally well tolerated as flower/leaf preparations. It contains salicylates, so use caution if you are salicylate-sensitive; the root in large doses is emetic and purgative.
Safety in pregnancy and breastfeeding is not established, so avoid medicinal doses.
Regarded as safe in customary traditional use; because the extract suppresses immune-cell activity, there is a theoretical caution when taking immunosuppressant medicines.
Contains salicylates, so use caution if you are salicylate-sensitive; safety in pregnancy and breastfeeding is not established.
External Ids
Botanical Description
Low, spreading perennial herb with heart-shaped, softly toothed leaves arising from a short rootstock, spreading by runners (stolons). Fragrant, deep violet-purple (occasionally white) flowers with five petals, the lower petal spurred, are borne singly on slender stalks.[11]
Small, low-growing annual or short-lived perennial herb with oval to lance-shaped, scalloped leaves and large, leaf-like stipules. The distinctive flowers are tricoloured - purple, yellow and white in varying combinations - with five petals, the lower petal often marked with dark veining (a 'face' pattern), giving rise to the name 'heartsease'.[9]
Habitat
Grows in woodland edges, hedgerows, shaded banks and gardens on moist, humus-rich soils; native to Europe, North Africa and Asia and widely naturalised and cultivated elsewhere.[11]
Grows in grassland, cultivated ground, gardens and waste places on a wide range of soils; native to Europe and widely naturalised elsewhere as a common garden and wild plant.[9]
Harvesting
Flowers are picked as they open in early spring; leaves can be gathered through the growing season and dried.[11]
The flowering aerial parts are cut in summer while in flower and dried in a warm, shaded, airy place.[9]
Traditional Uses
Sweet violet flower and leaf have a long European folk history as a soothing demulcent and expectorant remedy for cough, bronchitis and catarrh, and as a mild sedative for sleeplessness and headache; the flower syrup in particular has a long tradition as a children's cough remedy.[11]
Heartsease has a long European folk history as a soothing remedy for skin conditions such as eczema and itching, and as a traditional demulcent and expectorant for coughs and chest complaints; this traditional skin-supportive use is now linked to immunomodulatory cyclic peptides (cyclotides) unique to the Viola genus.[9]
Preparations
Dried flowering herb infused in hot water, taken internally for cough or used as a cooled compress for skin irritation.
Dosage
A double-blind randomised placebo-controlled trial used 5 mL of Viola odorata syrup every 12 hours for 4 weeks as add-on therapy for insomnia. Traditional references suggest around 2-4 g of dried flower and leaf per cup, up to three times daily. Note the EU monograph on Violae herba cum flore covers Viola tricolor, a different species, and its posology does not transfer here. Educational reference only, not a prescription.
The EU herbal monograph gives, for oral use in adults and elderly, 3 g of the comminuted herb as an infusion 1-3 times daily. For cutaneous use, 5-20 g/L as an infusion applied as a wet dressing 2-3 times daily, or 5-10 g/L as a bath additive (1 litre of infusion per bath). Contraindicated in hypersensitivity to salicylates, and cutaneously on open wounds or large areas of damaged skin. Oral use not recommended under 18 years. Educational reference only, not a prescription.
References
Drug Class Interactions
Not documented
Lookalikes Review
Dangerous Lookalikes
Not documented
References & Sources
- Feyzabadi, Z., Ghorbani, F., Vazani, Y. and Zarshenas, M.M (2017) 'A Critical Review on Phytochemistry, Pharmacology of Viola odorata L. and Related Multipotential Products in Traditional Persian Medicine', Phytotherapy Research, 31(11), pp. 1669-1675. doi:10.1002/ptr.5909 Meta-analysis / review
https://doi.org/10.1002/ptr.5909 - Heger, T., Zatloukal, M., Kubala, M., Strnad, M. and others (2022) 'Procyanidin C1 from Viola odorata L. inhibits Na,K-ATPase', Scientific Reports, 12(1), pp. 7011. doi:10.1038/s41598-022-11086-y Preclinical
https://doi.org/10.1038/s41598-022-11086-y - Yousefnia, S., Naseri, D., Seyed Forootan, F., Tabatabaeian, M. and others (2020) 'Suppressive role of Viola odorata extract on malignant characters of mammosphere-derived breast cancer stem cells', Clinical & Translational Oncology, 22(9), pp. 1619-1634. doi:10.1007/s12094-020-02307-9 Preclinical
https://doi.org/10.1007/s12094-020-02307-9 - Tafazoli, V., Shahriari, M., Heydari, M., Nikbakht, H.A. and others (2020) 'The Effect of Viola odorata L. Oil for Fever in Children: A Randomized Triple-blinded Placebo-controlled Clinical Trial', Current Drug Discovery Technologies, 17(5), pp. 696-703. doi:10.2174/1570163816666190620142256 Randomized trial
https://doi.org/10.2174/1570163816666190620142256 - Rahimi, V.B., Askari, V.R., Emami, S.A. and Tayarani-Najaran, Z (2017) 'Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells', Iranian Journal of Basic Medical Sciences, 20(3), pp. 242-249. doi:10.22038/ijbms.2017.8350 Preclinical
https://doi.org/10.22038/ijbms.2017.8350 - Adel Mehraban, M.S., Shirzad, M., Mohammad Taghizadeh Kashani, L., Ahmadian-Attari, M.M. and others (2022) 'Efficacy and safety of add-on Viola odorata L. in the treatment of COVID-19: A randomized double-blind controlled trial', Journal of Ethnopharmacology, 304, pp. 116058. doi:10.1016/j.jep.2022.116058 Randomized trial
https://doi.org/10.1016/j.jep.2022.116058 - Saleem, U., Hira, S., Anwar, F., Shah, M.A. and others (2021) 'Pharmacological Screening of Viola odorata L. for Memory-Enhancing Effect via Modulation of Oxidative Stress and Inflammatory Biomarkers', Frontiers in Pharmacology, 12, pp. 664832. doi:10.3389/fphar.2021.664832 Preclinical
https://doi.org/10.3389/fphar.2021.664832 - Shayesteh, M., Vaez-Mahdavi, M.R., Shams, J., Kamalinejad, M. and others (2020) 'Effects of Viola odorata as an Add-On Therapy on Insomnia in Patients with Obsession or Depression: A Pilot Randomized Double-Blind Placebo-Controlled Trial', Journal of Alternative and Complementary Medicine, 26(5), pp. 398-408. doi:10.1089/acm.2019.0254 Randomized trial
https://doi.org/10.1089/acm.2019.0254 - Feyzabadi, Z., Jafari, F., Kamali, S.H., Ashayeri, H. and others (2014) 'Efficacy of Viola odorata in Treatment of Chronic Insomnia', Iranian Red Crescent Medical Journal, 16(12), pp. e17511. doi:10.5812/ircmj.17511 Clinical study
https://doi.org/10.5812/ircmj.17511 - Parsley, N.C., Kirkpatrick, C.L., Crittenden, C.M., Rad, J.G. and others (2018) 'PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata', Phytochemistry, 152, pp. 61-70. doi:10.1016/j.phytochem.2018.04.014 Preclinical
https://doi.org/10.1016/j.phytochem.2018.04.014 - Herbal Reality (n.d.) 'Violets (Viola odorata): Benefits, Safety, Uses'. Available at: https://www.herbalreality.com/herb/violets/ Traditional / reference
https://www.herbalreality.com/herb/violets/ - Qasemzadeh, M.J., Sharifi, H., Hamedanian, M., Gharehbeglou, M., Heydari, M., Sardari, M., Akhlaghdoust, M. and Minae, M.B (2015) 'The Effect of Viola odorata Flower Syrup on the Cough of Children With Asthma: A Double-Blind, Randomized Controlled Trial', Journal of Evidence-Based Complementary & Alternative Medicine, 20(4), pp. 287--291. doi:10.1177/2156587215584862 Randomized trial
https://doi.org/10.1177/2156587215584862 - RxList (n.d.) 'Sweet Violet: Health Benefits, Side Effects, Uses, Dose & Precautions'. Available at: https://www.rxlist.com/supplements/sweet_violet.htm Traditional / reference
https://www.rxlist.com/supplements/sweet_violet.htm - Ghasemzadeh Rahbardar, M. and Hosseinzadeh, H (2024) 'Therapeutic potential of hypnotic herbal medicines: A comprehensive review', Phytotherapy Research, 38(6), pp. 3037-3059. doi:10.1002/ptr.8201 Meta-analysis / review
https://doi.org/10.1002/ptr.8201 - Block, K.I., Gyllenhaal, C. and Mead, M.N (2004) 'Safety and efficacy of herbal sedatives in cancer care', Integrative Cancer Therapies, 3(2), pp. 128-148. doi:10.1177/1534735404265003 Meta-analysis / review
https://doi.org/10.1177/1534735404265003 - Unruly Gardening 'Foraging Violets: How to Identify, Harvest and Use'. Available at: https://unrulygardening.com/foraging-violets/ Traditional / reference
https://unrulygardening.com/foraging-violets/
- Retzl, B., Zimmermann-Klemd, A.M., Winker, M., Nicolay, S., Grundemann, C. and Gruber, C.W (2023) 'Exploring Immune Modulatory Effects of Cyclotide-Enriched Viola tricolor Preparations', Planta Medica, 89(15), pp. 1493--1504. doi:10.1055/a-2173-8627 Preclinical
https://doi.org/10.1055/a-2173-8627 - Harati, E., Bahrami, M., Razavi, A., Kamalinejad, M. and others (2018) 'Effects of Viola tricolor Flower Hydroethanolic Extract on Lung Inflammation in a Mouse Model of Chronic Asthma', Iranian Journal of Allergy, Asthma, and Immunology, 17(5), pp. 409-417. doi:10.18502/ijaai.v17i5.299 Preclinical
https://doi.org/10.18502/ijaai.v17i5.299 - Sadeghnia, H.R., Ghorbani Hesari, T., Mortazavian, S.M., Mousavi, S.H. and others (2014) 'Viola tricolor induces apoptosis in cancer cells and exhibits antiangiogenic activity on chicken chorioallantoic membrane', BioMed Research International, 2014, pp. 625792. doi:10.1155/2014/625792 Preclinical
https://doi.org/10.1155/2014/625792 - Mousavi, S.H., Naghizade, B., Pourgonabadi, S. and Ghorbani, A (2016) 'Protective effect of Viola tricolor and Viola odorata extracts on serum/glucose deprivation-induced neurotoxicity: role of reactive oxygen species', Avicenna Journal of Phytomedicine, 6(4), pp. 434-441. Preclinical
https://scholar.google.com/scholar?q=Protective%20effect%20of%20Viola%20tricolor%20and%20Viola%20odorata%20extracts%20on%20serum/glucose%20deprivation-induced%20neurotoxicity%3A%20role%20of%20reactive%20oxygen%20species - Witkowska-Banaszczak, E., Bylka, W., Matlawska, I., Goslinska, O. and Muszynski, Z (2005) 'Antimicrobial activity of Viola tricolor herb', Fitoterapia, 76(5), pp. 458-461. doi:10.1016/j.fitote.2005.03.005 Preclinical
https://doi.org/10.1016/j.fitote.2005.03.005 - Baradaran Rahimi, V., Askari, V.R., Hosseini, M., Yousefsani, B.S. and Sadeghnia, H.R (2019) 'Anticonvulsant Activity of Viola tricolor against Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice', Iranian Journal of Medical Sciences, 44(3), pp. 220-226. Preclinical
https://scholar.google.com/scholar?q=Anticonvulsant%20Activity%20of%20Viola%20tricolor%20against%20Seizures%20Induced%20by%20Pentylenetetrazol%20and%20Maximal%20Electroshock%20in%20Mice - Piana, M., Silva, M.A., Trevisan, G., de Brum, T.F. and others (2013) 'Antiinflammatory effects of Viola tricolor gel in a model of sunburn in rats and the gel stability study', Journal of Ethnopharmacology, 150(2), pp. 458-465. doi:10.1016/j.jep.2013.08.040 Preclinical
https://doi.org/10.1016/j.jep.2013.08.040 - Han, B.Y., Wang, Z.L., Li, J., Jin, Q. and others (2023) 'A highly selective C-rhamnosyltransferase from Viola tricolor and insights into its mechanisms', Acta Pharmaceutica Sinica B, 13(8), pp. 3535-3544. doi:10.1016/j.apsb.2023.05.011 Preclinical
https://doi.org/10.1016/j.apsb.2023.05.011 - Hellinger, R., Koehbach, J., Fedchuk, H., Sauer, B., Huber, R., Gruber, C.W. and Grundemann, C (2013) 'Immunosuppressive activity of an aqueous Viola tricolor herbal extract', Journal of Ethnopharmacology, pp. 2013. doi:10.1016/j.jep.2013.10.044 Traditional / reference
https://doi.org/10.1016/j.jep.2013.10.044 - Kirichenko, T.V., Sobenin, I.A., Nikolic, D., Rizzo, M. and Orekhov, A.N (2015) 'Anti-cytokine therapy for prevention of atherosclerosis', Phytomedicine, 23(11), pp. 1198-1210. doi:10.1016/j.phymed.2015.12.002 Clinical study
https://doi.org/10.1016/j.phymed.2015.12.002 - Conzelmann, C., Muratspahic, E., Tomasevic, N., Munch, J. and Gruber, C.W (2022) 'Inhibition of HIV-1 by Cyclotide-Enriched Extracts of Viola tricolor', Frontiers in Pharmacology, 13, pp. 888961. doi:10.3389/fphar.2022.888961 Preclinical
https://doi.org/10.3389/fphar.2022.888961 - Maraschio, A., Wulhfard, K. and Monsellato, L (2023) 'Case study of clinical improvement of atopic dermatitis in a patient treated with herbal-based parapharmaceuticals', Journal of Complementary & Integrative Medicine, 20(2), pp. 504-511. doi:10.1515/jcim-2023-0005 Clinical study
https://doi.org/10.1515/jcim-2023-0005 - Svangard, E. and Goransson, U. and Hocaoglu, Z. and Gullbo, J. and Larsson, R. and Claeson, P. and Bohlin, L (2004) 'Cytotoxic cyclotides from Viola tricolor', Journal of Natural Products, 67(2), pp. 144--147. doi:10.1021/np030101l Preclinical
https://doi.org/10.1021/np030101l - European Medicines Agency (HMPC) (2010) 'Community herbal monograph on Viola tricolor L. and/or subspecies Viola arvensis Murray (Gaud) and Viola vulgaris Koch (Oborny), herba cum flore'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-viola-tricolor-l_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-viola-tricolor-l_en.pdf
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.