Plant Comparison
Labrador-tea vs Common coltsfoot
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Labrador-tea and Common coltsfoot: they share 3 indicated uses (arthritis / joint pain, inflammation (general), skin irritation); 1 pharmacological action in common.
Evidence face-off — shared uses
| Condition | Labrador-tea | Common coltsfoot | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 2/10 | 1/10 | Comparable evidence |
| Inflammation (general) | 1/10 | 2/10 | Comparable evidence |
| Skin irritation | 1/10 | 1/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Ledol is the characteristic, mildly toxic sesquiterpene alcohol of the leaf, particularly concentrated in fresh material.
Toxic diterpenes shared with related Ericaceae; the basis for the caution around excessive or prolonged use.
Hepatotoxic constituents that are the central safety concern for this plant; regulatory limits and PA-controlled/PA-reduced products exist specifically because of these compounds.
Demulcent polysaccharide contributing to the traditional soothing action on irritated airways.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from diuretic action
inferred from diuretic action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from sedative action
Safety, Cautions & Contraindications
Labrador tea contains ledol, a toxic sesquiterpene alcohol, particularly concentrated in fresh leaves. Excessive consumption can cause dizziness, headache, nausea, and even toxicity (especially in the related Ledum palustre). Use only in small, controlled amounts. Not recommended during pregnancy or breastfeeding. Identify plant correctly — confusion with other bog plants can be dangerous.
Duke (2002) rates Labrador tea as + (caution warranted) and notes primarily folkloric activities, with the plant acting as a diuretic, expectorant, and vulnerary. Importantly, Duke classifies it as having narcotic and deliriant potential — large doses can cause intoxication, hallucinations, and toxicity. It contains ericolin and ledol, which are potentially neurotoxic compounds. Duke emphasizes that Labrador tea should be used only with caution and at low doses, and notes that it is not appropriate for regular internal use given its toxicity profile at higher amounts (Duke, 2002).
Safety notes (contraindications, interactions, pregnancy/lactation notes, adverse effects, dose-duration cautions) Important: Coltsfoot naturally contains pyrrolizidine alkaloids (PAs)—plant chemicals that can damage the liver and may increase cancer risk with enough exposure (EMA, 2021; Kopp et al., 2020).
Because of this, European regulators set very strict limits for PA exposure from herbal products (EMA, 2021).
Many safety-focused herbal references recommend avoiding homemade/internal coltsfoot use, unless the product is specifically made to be PA-controlled / PA-reduced (EMA, 2021).
Avoid internal use if you are pregnant or breastfeeding, have liver disease, or for children—these groups are treated as “sensitive” in PA risk guidance (EMA, 2021).
Medication caution: if you take medicines that stress the liver (some prescription drugs can), it’s extra important to avoid unregulated PA exposure (general PA risk logic; consult a clinician) (EMA, 2021).
Topical use may still carry PA considerations; EMA discusses limits and recommends use only on intact skin for PA-containing products (EMA, 2021).
Duke (2002) provides clinical support (score 2) for coltsfoot's anti-inflammatory and expectorant effects, explaining its traditional use in bronchitis and coughs. However, the plant contains hepatotoxic pyrrolizidine alkaloids (PAs), and Duke notes a carcinogenic score (1) — a critical safety concern. Commission E has placed restrictions on coltsfoot use, recommending maximum internal use of 4–6 weeks per year and avoiding use in pregnancy, lactation, and in children under 12. Duke rates its overall safety as low (+) and emphasizes that preparations free of PAs are preferred (Duke, 2002).
External Ids
Botanical Description
Low evergreen shrub (Ericaceae), 30-100 cm tall. Leaves are narrow, leathery, with in-rolled margins and a dense, rust-coloured, woolly felt on the underside, strongly aromatic when crushed. Small white flowers are borne in terminal clusters.[4]
Low perennial herb notable for flowering before its leaves appear: solitary, bright yellow, dandelion-like flower heads emerge on scaly pinkish stalks in very early spring, followed later by large, hoof-shaped (heart-shaped with angular teeth), white-woolly-backed leaves arising directly from the creeping rhizome.[11]
Habitat
Grows on disturbed, damp or clay-rich waste ground, riverbanks, railway embankments and bare soil; native to Europe, North Africa and temperate Asia and naturalised in North America.[11]
Harvesting
Leaves and young stems are gathered, traditionally in late summer, and dried. Only small amounts are used given the plant's ledol/grayanotoxin content, and correct identification against toxic bog look-alikes (bog rosemary) is essential.[6]
Flowers are gathered in very early spring before the leaves appear; leaves are gathered later in the season once expanded. Given the plant's pyrrolizidine alkaloid content, harvesting from a positively confirmed patch (not a look-alike) and preferring PA-tested commercial material for internal use is strongly advised.[2]
Traditional Uses
Labrador tea has a long Indigenous North American and Scandinavian folk-medicine tradition as a mild diuretic and respiratory remedy, and as an aromatic tea and spice, always used in small, cautious amounts given its narcotic/toxic potential at higher doses. Modern phytochemical work confirms anti-inflammatory and antioxidant activity of its essential oil.[1]
Coltsfoot has an ancient European and Chinese tradition, reflected in its Latin name (tussis = cough), as an expectorant and demulcent remedy for coughs, bronchitis and irritated airways; because of its pyrrolizidine alkaloid content, contemporary use is restricted to short courses of PA-controlled preparations under regulatory limits (see contraindications).[1, 2, 12]
Preparations
Commercially prepared, pyrrolizidine-alkaloid-tested extract or syrup, the only form recommended for internal use given the plant's natural PA content.
Dried flower or leaf infused in hot water; traditional but subject to strict duration/PA-content limits under EU herbal regulation.
Dosage
Duke (2002) advises using Labrador tea only with caution and at low doses given its narcotic/deliriant potential at higher amounts; it is not appropriate for regular internal use. Educational reference only, not a prescription - use only small, occasional amounts of properly identified leaf.
EU regulatory guidance restricts internal use to PA-controlled preparations. The EMA public statement on unsaturated pyrrolizidine alkaloids records a maximum daily intake for internal use of 1 microgram of PAs for at most 6 weeks per year, or 0.1 microgram per day with no duration limit; for cutaneous use the limits are 100 micrograms for at most 6 weeks per year, or 10 micrograms without a duration limit. Not for use in pregnancy, breastfeeding, or children. Note that these are limits on PA intake, not a herb dose — no EMA monograph exists for Tussilago farfara, so there is no official posology for the herb itself. Educational reference only, not a prescription — consult a qualified practitioner and prefer tested commercial products.
References
Lookalikes Review
Dangerous Lookalikes
References & Sources
- Dampc, A. and Luczkiewicz, M (2013) 'Rhododendron tomentosum (Ledum palustre): a review of traditional use based on current research', pp. 130--143. Traditional / reference
https://scholar.google.com/scholar?q=Rhododendron%20tomentosum%20%28Ledum%20palustre%29%3A%20a%20review%20of%20traditional%20use%20based%20on%20current%20research - Jesionek, A., Kokotkiewicz, A., Mikosik-Roczynska, A., Ciesielska-Figlon, K. and others (2019) 'Chemical variability of Rhododendron tomentosum (Ledum palustre) essential oils and their pro-apoptotic effect on lymphocytes and rheumatoid arthritis synoviocytes', Fitoterapia, 139, pp. 104402. doi:10.1016/j.fitote.2019.104402 Preclinical
https://doi.org/10.1016/j.fitote.2019.104402 - Kang, J.Y., Tran, K.D., Seiff, S.R., Mack, W.P. and Lee, W.W (2017) 'Assessing the Effectiveness of Arnica montana and Rhododendron tomentosum (Ledum palustre) in the Reduction of Ecchymosis and Edema After Oculofacial Surgery: Preliminary Results', Ophthalmic Plastic and Reconstructive Surgery, 33(1), pp. 47-52. doi:10.1097/IOP.0000000000000645 Clinical study
https://doi.org/10.1097/IOP.0000000000000645 - Vengryte, M. and Raudone, L (2024) 'Phytochemical Profiling and Biological Activities of Rhododendron subsect. Ledum: Discovering the Medicinal Potential of Labrador Tea Species in the Northern Hemisphere', Plants (Basel), 13(6), pp. 901. doi:10.3390/plants13060901 Traditional / reference
https://doi.org/10.3390/plants13060901 - Iunusova, D.R., Polezhaeva, M.A. and Marchuk, E.A (2024) 'Confusing boundaries of the Labrador tea species: dispersal history explains the lack of clear species structure', Annals of Botany, 134(6), pp. 959-974. doi:10.1093/aob/mcae130 Preclinical
https://doi.org/10.1093/aob/mcae130 - Dampc, A. and Luczkiewicz, M (2014) 'Labrador tea - the aromatic beverage and spice: a review of origin, processing and safety', Journal of the Science of Food and Agriculture, 95(8), pp. 1577-1583. doi:10.1002/jsfa.6889 Traditional / reference
https://doi.org/10.1002/jsfa.6889 - Jaenson, T.G.T., Palsson, K. and Borg-Karlson, A.K (2005) 'Evaluation of extracts and oils of tick-repellent plants from Sweden', Medical and Veterinary Entomology, 19(4), pp. 345-352. doi:10.1111/j.1365-2915.2005.00578.x Preclinical
https://doi.org/10.1111/j.1365-2915.2005.00578.x - Tattje, D.H.E. and Bos, R (1981) 'Composition of essential oil of Ledum palustre', Planta Medica, 41(3), pp. 303-307. doi:10.1055/s-2007-971719 Preclinical
https://doi.org/10.1055/s-2007-971719 - Zhang, K., Wang, J., Chen, L., Li, J. and others (2019) 'Two new taraxerane-type triterpenes from Ledum palustre L', Natural Product Research, 34(19), pp. 2723-2728. doi:10.1080/14786419.2019.1586689 Preclinical
https://doi.org/10.1080/14786419.2019.1586689 - Islam, M.N., Khalil, M.I., Islam, M.A. and Gan, S.H (2013) 'Toxic compounds in honey', Journal of Applied Toxicology, 34(7), pp. 733-742. doi:10.1002/jat.2952 Traditional / reference
https://doi.org/10.1002/jat.2952 - Baananou, S., Bagdonaite, E., Marongiu, B., Piras, A. and others (2014) 'Supercritical CO2 extract and essential oil of aerial part of Ledum palustre L. - Chemical composition and anti-inflammatory activity', Natural Product Research, 29(11), pp. 999-1005. doi:10.1080/14786419.2014.965167 Preclinical
https://doi.org/10.1080/14786419.2014.965167 - Grieve, M (1931) 'A Modern Herbal'. Traditional / reference
https://scholar.google.com/scholar?q=A%20Modern%20Herbal - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Kirtley, Paul (2015) 'Labrador Tea - Tonic or Toxic?'. Available at: https://paulkirtley.co.uk/2015/labrador-tea-tonic-or-toxic/ Traditional / reference
https://paulkirtley.co.uk/2015/labrador-tea-tonic-or-toxic/ - Jiang, L. and Zhanxiong, L. and Fengcai, Y. and Fuli, L. and Xiaoling, S (2022) 'Third-degree atrioventricular block caused by intoxication with rhododendron leaves', Annals of Noninvasive Electrocardiology, 28(2), pp. e13012. doi:10.1111/anec.13012 Clinical study
https://doi.org/10.1111/anec.13012
- Ahmad, I., Kudaibergenova, B., Ahmad, M. and others (2025) 'Coltsfoot (Tussilago farfara L.; Asteraceae): modern methods of extraction, phytochemistry, nanoparticles synthesis, ethnopharmacology, and biological activities', Natural Product Research, pp. 1-20. doi:10.1080/14786419.2025.2548616 Traditional / reference
https://doi.org/10.1080/14786419.2025.2548616 - Chen, S., Dong, L., Quan, H., Zhou, X. and others (2020) 'A review of the ethnobotanical value, phytochemistry, pharmacology, toxicity and quality control of Tussilago farfara L. (coltsfoot)', Journal of Ethnopharmacology, 267, pp. 113478. doi:10.1016/j.jep.2020.113478 Traditional / reference
https://doi.org/10.1016/j.jep.2020.113478 - Feng, J., Zhang, Y., Qin, X., Gao, T. and others (2022) 'Novel Quinic Acid Glycerates from Tussilago farfara Inhibit Polypeptide GalNAc-Transferase', ChemBioChem, 23(3), pp. e202100539. doi:10.1002/cbic.202100539 Preclinical
https://doi.org/10.1002/cbic.202100539 - Zhao, J., Evangelopoulos, D., Bhakta, S., Gray, A.I. and Seidel, V (2014) 'Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents', Journal of Ethnopharmacology, 155(1), pp. 796-800. doi:10.1016/j.jep.2014.06.034 Preclinical
https://doi.org/10.1016/j.jep.2014.06.034 - Avila, C., Breakspear, I., Hawrelak, J., Salmond, S. and Evans, S (2020) 'A systematic review and quality assessment of case reports of adverse events for borage (Borago officinalis), coltsfoot (Tussilago farfara) and comfrey (Symphytum officinale)', Fitoterapia, 142, pp. 104519. doi:10.1016/j.fitote.2020.104519 Meta-analysis / review
https://doi.org/10.1016/j.fitote.2020.104519 - Lee, J., Park, S., Kim, M.J., Kwon, S.J. and others (2019) 'Sesquiterpenoids from Tussilago farfara Flower Bud Extract for the Eco-Friendly Synthesis of Silver and Gold Nanoparticles Possessing Antibacterial and Anticancer Activities', Nanomaterials (Basel), 9(6), pp. 819. doi:10.3390/nano9060819 Preclinical
https://doi.org/10.3390/nano9060819 - Bota, V.B., Neamtu, A.A., Olah, N.K., Chiselita, O. and others (2022) 'A Comparative Analysis of the Anatomy, Phenolic Profile, and Antioxidant Capacity of Tussilago farfara L. Vegetative Organs', Plants (Basel), 11(13), pp. 1663. doi:10.3390/plants11131663 Preclinical
https://doi.org/10.3390/plants11131663 - Boucher, M.A., Cote, H., Pichette, A., Ripoll, L. and Legault, J (2020) 'Chemical composition and antibacterial activity of Tussilago farfara (L.) essential oil from Quebec, Canada', Natural Product Research, 34(4), pp. 545-548. doi:10.1080/14786419.2018.1489384 Preclinical
https://doi.org/10.1080/14786419.2018.1489384 - Li, Z.Y., Zhang, J., Zhang, Y.B., Yang, X.W. and others (2022) 'Polyhydroxylated eudesmane sesquiterpenoids and sesquiterpenoid glucoside from the flower buds of Tussilago farfara', Chinese Journal of Natural Medicines, 20(4), pp. 301-308. doi:10.1016/S1875-5364(21)60120-6 Preclinical
https://doi.org/10.1016/S1875-5364(21)60120-6 - Jang, H., Lee, J.W., Lee, C., Jin, Q. and others (2016) 'Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells', Archives of Pharmacal Research, 39(1), pp. 127-132. doi:10.1007/s12272-015-0667-7 Preclinical
https://doi.org/10.1007/s12272-015-0667-7 - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Westendorf, J., Czok, G., Marquardt, R., Nausner, M., Krauer, B. and Paul, H.L (1988) 'Pyrrolizidine alkaloid content of Tussilago farfara plants from different regions and preparations', pp. 903--909. Traditional / reference
https://scholar.google.com/scholar?q=Pyrrolizidine%20alkaloid%20content%20of%20Tussilago%20farfara%20plants%20from%20different%20regions%20and%20preparations - European Medicines Agency (HMPC) (2021) 'Public statement on the use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs), including recommendations regarding contamination of herbal medicinal products with PAs, Revision 1'. Available at: https://www.ema.europa.eu/en/documents/public-statement/public-statement-use-herbal-medicinal-products-containing-toxic-unsaturated-pyrrolizidine-alkaloids-pas-including-recommendations-regarding-contamination-herbal-medicinal-products-pyrrolizidine_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/public-statement/public-statement-use-herbal-medicinal-products-containing-toxic-unsaturated-pyrrolizidine-alkaloids-pas-including-recommendations-regarding-contamination-herbal-medicinal-products-pyrrolizidine_en.pdf - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Sperl, W. and Stuppner, H. and Gassner, I. and Judmaier, W. and Dietze, O. and Vogel, W (1995) 'Reversible hepatic veno-occlusive disease in an infant after consumption of pyrrolizidine-containing herbal tea', European Journal of Pediatrics, 154(2), pp. 112-6. doi:10.1007/BF01991912 Clinical study
https://doi.org/10.1007/BF01991912
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.