Plant Comparison
White Dead Nettle vs Red Clover
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
First plant
Second plant
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At a glance
White Dead Nettle and Red Clover: they share 7 indicated uses (arthritis / joint pain, bronchitis, cough, …); 4 pharmacological actions in common.
White Dead NettleRed Clover
Constituents32
Pharmacological actions510
Indicated uses916
Safety notes42
Cited sources2644
Indicated uses
Only White Dead Nettle
BruisingDiarrhoea
Shared (7)
Arthritis / joint painBronchitisCoughInflammation (general)Respiratory supportSkin irritationWounds
Only Red Clover
Cardiovascular / heart healthMenstrual crampsMuscle spasmMenopauseHot flashesHigh cholesterolCancer (anticancer research)Blood sugar / diabetes supportCognitive function
Pharmacological actions
Only White Dead Nettle
Astringent
Shared (4)
Anti-inflammatoryAntioxidantExpectorantVulnerary (wound healing)
Only Red Clover
AntispasmodicLipid-loweringAnticancer (preclinical)Neuroprotective / cognition supportAntidiabetic (blood-sugar lowering)Antimicrobial
Evidence face-off — shared uses
| Condition | White Dead Nettle | Red Clover | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 2/10 | 5/10 | Stronger for Red Clover |
| Bronchitis | 1/10 | 5/10 | Stronger for Red Clover |
| Cough | 1/10 | 5/10 | Stronger for Red Clover |
| Inflammation (general) | 2/10 | 5/10 | Stronger for Red Clover |
| Respiratory support | 1/10 | 5/10 | Stronger for Red Clover |
| Skin irritation | 2/10 | 5/10 | Stronger for Red Clover |
| Wounds | 1/10 | 7/10 | Stronger for Red Clover |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Phenylpropanoid and flavonoid glycosides[13]
Verbascoside, tiliroside and quercetin/kaempferol 3-O-glucosides in the flowers.
Verbascoside (acteoside)GlycosidesKaempferolFlavonoidsQuercetin
Iridoid glycosides[14]
Lamalbid, alboside A and B and caryoptoside; linked to antioxidant and anti-inflammatory activity.
Iridoid glycosidesGlycosides
Standardisation markers (Lamii albi flos)[15]
Lamalbid, chlorogenic acid, verbascoside, rutin and tiliroside, richest in the flowering tops.
Chlorogenic acidVerbascoside (acteoside)Rutin
Isoflavones (formononetin, biochanin A, daidzein, genistein)[14]
Phytoestrogenic isoflavones responsible for the plant's estrogenic and cardiovascular research interest; one of the richest known plant sources.
Flavonoids
Coumarins[40]
Contribute mild anticoagulant activity; relevant to the plant's caution around blood-thinning medication.
Coumarins
Pharmacological Actions
Astringent and anti-inflammatory infusion or tincture (flowering tops)
Parts: Flower, Aerial parts
Astringent (catarrh, excessive menstrual or vaginal discharge); Astringent and anti-inflammatory infusion or tincture (flowering tops)
Parts: Flower, Aerial parts
Traditional & Indicated Uses
inferred from anti-inflammatory action
Evidence: 2
Label: Arthritis / joint pain
Astringent (catarrh, excessive menstrual or vaginal discharge)
Evidence: 1
Label: Cough
inferred from anti-inflammatory action
Evidence: 2
Label: Inflammation (general)
inferred from expectorant action
Evidence: 1
Label: Respiratory support
inferred from astringent action
Evidence: 2
Label: Skin irritation
inferred from anti-inflammatory action
Evidence: 5
Label: Arthritis / joint pain
Evidence: 9
Label: Cardiovascular / heart health
inferred from anti-inflammatory action
Evidence: 5
Label: Inflammation (general)
inferred from antispasmodic action
Evidence: 5
Label: Muscle spasm
inferred from expectorant action
Evidence: 5
Label: Respiratory support
inferred from anti-inflammatory action
Evidence: 5
Label: Skin irritation
inferred from anticancer action
Evidence: 7
Label: Cancer (anticancer research)
Evidence: 2
Label: Blood sugar / diabetes support
inferred from neuroprotective action
Evidence: 8
Label: Cognitive function
Safety, Cautions & Contraindications
Safety note[19]Info
Generally regarded as safe in culinary amounts and at normal medicinal doses; unlike the stinging nettle it has no stinging hairs.
Medicinal use during pregnancy or breastfeeding should be approached cautiously, as for any traditional astringent.
Identify correctly before foraging (resembles stinging nettle before flowering and red dead-nettle); clinical evidence is limited, so it should not replace conventional treatment.
Generally safe in normal dietary amounts. Isoflavones are phytoestrogens — exercise caution in oestrogen-receptor-positive breast cancer patients or those taking hormone therapies. May interact with warfarin (antiplatelet activity). Avoid in pregnancy and breastfeeding. Well tolerated in most adults.
Duke (2002) rates red clover as +++ and provides clinical evidence (score 2) for estrogenic activity — the plant is one of the richest plant sources of isoflavones (formononetin, biochanin A, daidzein, genistein). Clinical applications include menopausal symptom relief, osteoporosis prevention, and cardiovascular protection in peri-menopausal women. Dose: standardized extract providing 40–160 mg isoflavones daily. Duke cautions that due to strong estrogenic activity, red clover is not recommended in estrogen-dependent cancers (breast, uterine) or alongside hormone replacement therapy without medical supervision. Anti-coagulant coumarins are also present (Duke, 2002).
External Ids
Gbif: 2926683
Wikidata: Q157626
Gbif: 8324121
Wikidata: Q156635
Botanical Description
Perennial herb closely resembling stinging nettle in leaf shape but entirely without stinging hairs. Square stems bear opposite, toothed, heart-shaped leaves, and whorls of white, hooded, two-lipped flowers cluster in the upper leaf axils.[15]
Height: 20-60 cm
Habit: Erect, clump-forming perennial herb
Leaves: Opposite, toothed, heart-shaped, resembling stinging nettle but without stinging hairs
Flowers: White, hooded, two-lipped, in dense whorls in the upper leaf axils
Stem: Square (typical of the mint family), unarmed (no stinging hairs)
Root: Creeping rhizome
Fruit: Small nutlet (typical of Lamiaceae)
Flowering Period: March-November (almost year-round in mild climates)
Short-lived perennial herb with trifoliate leaves, each leaflet oval and often marked with a pale chevron, arising from a spreading, slightly hairy stem. Dense, rounded, pink to magenta flower heads are borne at the stem tips.[40]
Height: 20-60 cm
Habit: Short-lived perennial herb, spreading via a branching taproot
Leaves: Trifoliate, each leaflet oval with a pale chevron marking, slightly hairy
Flowers: Dense, rounded heads of small pink to magenta pea-like flowers
Stem: Slightly hairy, branching, spreading
Root: Branching taproot with nitrogen-fixing root nodules
Fruit: Small pod containing 1-2 seeds, enclosed within the dried flower head
Flowering Period: May-September
Habitat
Grows in hedgerows, waste ground, gardens and roadsides on nitrogen-rich soils; native to Europe and temperate Asia, widely naturalised elsewhere.
Grows in meadows, pastures, roadsides and grassy waste ground; native to Europe, western Asia and North Africa and widely naturalised and cultivated as a forage crop elsewhere.[40]
Harvesting
The flowering tops are picked as they open, largely through spring to autumn given the long flowering season, and dried in a warm, shaded, airy place; the standardisation markers are richest in the flowering tops specifically.[15]
Parts: Flower, Leaf, Aerial parts
Season: Spring through autumn, as flowers open
The flowering heads are picked at full bloom in summer and dried quickly in a warm, shaded, airy place to preserve isoflavone content and colour.[40]
Parts: Flower, Leaf
Season: Summer, at full bloom
Traditional Uses
White dead-nettle flower has a long European folk history as an astringent remedy for catarrh and excessive menstrual or vaginal discharge, and topically as a vulnerary wash for minor wounds; the young leaves and shoots have also traditionally been eaten as a cooked spring pot-herb.
Red clover flower has a long folk tradition as a blood-purifying and expectorant remedy for coughs and skin complaints, and more recently has become one of the most studied herbal sources of isoflavone phytoestrogens, researched for menopausal symptom relief and cardiovascular and bone support.[14, 40, 41]
References
REF-1746, REF-1747, REF-1748, REF-1749, REF-1750, REF-1751, REF-1752, REF-1753, REF-1754, REF-1755, REF-1756, REF-1757
REF-1104, REF-1105, REF-1106, REF-1107, REF-1108, REF-1109, REF-1110, REF-1111, REF-1112, REF-1113, REF-2344, REF-2345, REF-2346, REF-0013, REF-2347, REF-2889, REF-2890, REF-2891, REF-2892, REF-2893, REF-2894, REF-2895, REF-2896, REF-2897, REF-2898, REF-2899, REF-2900, REF-2923, REF-2924, REF-2925, REF-2926, REF-2927, REF-2928, REF-2929, REF-2930, REF-2931, REF-2932, REF-2933, REF-2934
Lookalikes Review
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Preparations
Dosage
Not documented
Standardized extract[14]
Clinical research commonly uses around 40-80 mg isoflavones daily. Educational reference only, not a prescription.
Drug Class Interactions
Not documented
Drug Class: hormonal-therapies
Mechanism: Red clover is rich in isoflavones that act like weak oestrogens; its safety alongside hormone medicines (such as the contraceptive pill, HRT, or breast-cancer hormone treatments like tamoxifen) or in hormone-sensitive conditions is not established, so combined use warrants caution and medical advice.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03
References & Sources
- Czerwinska, M.E., Swierczewska, A., Wozniak, M. and Kiss, A.K (2017) 'Bioassay-Guided Isolation of Iridoids and Phenylpropanoids from Aerial Parts of Lamium album and Their Anti-inflammatory Activity in Human Neutrophils', Planta Medica, 83(12-13), pp. 1011-1019. doi:10.1055/s-0043-107031 Preclinical
https://doi.org/10.1055/s-0043-107031 - Czerwinska, M.E., Swierczewska, A. and Granica, S (2018) 'Bioactive Constituents of Lamium album L. as Inhibitors of Cytokine Secretion in Human Neutrophils', Molecules, 23(11), pp. 2770. doi:10.3390/molecules23112770 Preclinical
https://doi.org/10.3390/molecules23112770 - Czerwinska, M.E., Kalinowska, E., Popowski, D. and Bazylko, A (2020) 'Lamalbid, Chlorogenic Acid, and Verbascoside as Tools for Standardization of Lamium album Flowers - Development and Validation of HPLC-DAD Method', Molecules, 25(7), pp. 1721. doi:10.3390/molecules25071721 Preclinical
https://doi.org/10.3390/molecules25071721 - Sulborska, A., Konarska, A., Matysik-Wozniak, A., Dmitruk, M., Weryszko-Chmielewska, E., Skalska-Kaminska, A. and Rejdak, R (2020) 'Phenolic Constituents of Lamium album L. subsp. album Flowers: Anatomical, Histochemical, and Phytochemical Study', Molecules, 25(24), pp. 6025. doi:10.3390/molecules25246025 Preclinical
https://doi.org/10.3390/molecules25246025 - Konarska, A., Weryszko-Chmielewska, E., Matysik-Wozniak, A., Sulborska, A., Polak, B., Dmitruk, M., Piotrowska-Weryszko, K., Stefanczyk, B. and Rejdak, R (2021) 'Histochemical and Phytochemical Analysis of Lamium album subsp. album L. Corolla: Essential Oil, Triterpenes, and Iridoids', Molecules, 26(14), pp. 4166. doi:10.3390/molecules26144166 Preclinical
https://doi.org/10.3390/molecules26144166 - Khanaki, K., Fekri, A., Abedinzade, M., Mohammadi, E. and Aghajanpour, F (2022) 'Potential anti-inflammatory effect of Lamium album extract through caspase-3 and cyclooxygenase-2 genes expression in a rat model of middle cerebral artery occlusion', Folia Medica, 64(2), pp. 275-282. doi:10.3897/folmed.64.e60562 Preclinical
https://doi.org/10.3897/folmed.64.e60562 - Bubueanu, C., Iuksel, R. and Panteli, M (2019) 'Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts', Acta Pharmaceutica, 69(3), pp. 443-449. doi:10.2478/acph-2019-0026 Preclinical
https://doi.org/10.2478/acph-2019-0026 - Arefani, S., Mehran, S.M.M., Moladoust, H., Norasfard, M.R., Ghorbani, A. and Abedinzade, M (2018) 'Effects of standardized extracts of Lamium album and Urtica dioica on rat tracheal smooth muscle contraction', Journal of Pharmacopuncture, 21(2), pp. 70-75. doi:10.3831/KPI.2018.21.008 Preclinical
https://doi.org/10.3831/KPI.2018.21.008 - Zhang, H., Rothwangl, K., Mesecar, A.D., Sabahi, A., Rong, L. and Fong, H.H.S (2009) 'Lamiridosins, hepatitis C virus entry inhibitors from Lamium album', Journal of Natural Products, 72(12), pp. 2158-2162. doi:10.1021/np900549e Preclinical
https://doi.org/10.1021/np900549e - Chipeva, V.A., Petrova, D.C., Geneva, M.E., Dimitrova, M.A., Moncheva, P.A. and Kapchina-Toteva, V.M (2013) 'Antimicrobial activity of extracts from in vivo and in vitro propagated Lamium album L. plants', African Journal of Traditional, Complementary and Alternative Medicines, 10(6), pp. 559-562. doi:10.4314/ajtcam.v10i6.30 Preclinical
https://doi.org/10.4314/ajtcam.v10i6.30 - Paduch, R. and Wozniak, A (2015) 'The Effect of Lamium album Extract on Cultivated Human Corneal Epithelial Cells (10.014 pRSV-T)', Journal of Ophthalmic & Vision Research, 10(3), pp. 229-237. doi:10.4103/2008-322X.170349 Preclinical
https://doi.org/10.4103/2008-322X.170349 - Abedinzade, M., Rostampour, M., Mirzajani, E., Khalesi, Z.B., Pourmirzaee, T. and Khanaki, K (2019) 'Urtica Dioica and Lamium Album Decrease Glycogen Synthase Kinase-3 beta and Increase K-Ras in Diabetic Rats', Journal of Pharmacopuncture, 22(4), pp. 248-252. doi:10.3831/KPI.2019.22.033 Preclinical
https://doi.org/10.3831/KPI.2019.22.033 - Budzianowski, J. and Skrzypczak, L (1995) 'Phenylpropanoid esters from Lamium album flowers', 38(4), pp. 997--1001. doi:10.1016/0031-9422(94)00727-B Traditional / reference
https://doi.org/10.1016/0031-9422(94)00727-B - Damtoft, S (1992) 'Iridoid glucosides from Lamium album', 31(1), pp. 175--178. doi:10.1016/0031-9422(91)83030-O Traditional / reference
https://doi.org/10.1016/0031-9422(91)83030-O - Pietrzak, W. and Nowak, R (2020) 'Lamalbid, Chlorogenic Acid, and Verbascoside as Tools for Standardization of Lamium album Flowers - Development and Validation of HPLC-DAD Method', 25(8). doi:10.3390/molecules25081913 Preclinical
https://doi.org/10.3390/molecules25081913 - Grieve, M (1931). Available at: https://botanical.com/botanical/mgmh/n/netwhd11.html Traditional / reference
https://botanical.com/botanical/mgmh/n/netwhd11.html - Herbal Reality (n.d.) 'White Deadnettle (Lamium album): Benefits, Uses, Safety'. Available at: https://www.herbalreality.com/herb/white-deadnettle/ Traditional / reference
https://www.herbalreality.com/herb/white-deadnettle/ - Ask-Ayurveda (n.d.) 'Lamium album (White Dead-Nettle) in Ayurveda - Benefits, Uses, Medicinal Properties & Healing Applications'. Available at: https://ask-ayurveda.com/wiki/article/4805-lamium-album Traditional / reference
https://ask-ayurveda.com/wiki/article/4805-lamium-album - Francis-Baker, T (2021), pp. 48. Traditional / reference
https://scholar.google.com/scholar?q=Francis-Baker%2C%20T - First Nature (n.d.) 'Lamium album, White Dead-nettle: identification, distribution, habitat'. Available at: https://www.first-nature.com/flowers/lamium-album.php Traditional / reference
https://www.first-nature.com/flowers/lamium-album.php - Ballyrobert Gardens (n.d.) 'Lamium album'. Available at: https://www.ballyrobertgardens.com/products/lamium-album Traditional / reference
https://www.ballyrobertgardens.com/products/lamium-album - Botanical Society of Scotland (2022) 'Plant of the Week - 17 January 2022: the White Dead-nettle (Lamium album)'. Available at: https://botsocscot.wordpress.com/2022/01/16/plant-of-the-week-january-17th-2022-the-white-dead-nettle-lamium-album/ Traditional / reference
https://botsocscot.wordpress.com/2022/01/16/plant-of-the-week-january-17th-2022-the-white-dead-nettle-lamium-album/ - Gardeners' World (2024) 'World (2024)'. Available at: https://www.gardenersworld.com/plants/dead-nettles/ Traditional / reference
https://www.gardenersworld.com/plants/dead-nettles/ - Royal Botanic Gardens, Kew (n.d.) 'Lamium album L'. Available at: https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:448792-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:448792-1 - Royal Horticultural Society (n.d.) 'Lamium album (white deadnettle)'. Available at: https://www.rhs.org.uk/plants/9810/lamium-album/details Traditional / reference
https://www.rhs.org.uk/plants/9810/lamium-album/details - The Wildlife Trusts (n.d.) 'White dead-nettle'. Available at: https://www.wildlifetrusts.org/wildlife-explorer/wildflowers/white-dead-nettle Traditional / reference
https://www.wildlifetrusts.org/wildlife-explorer/wildflowers/white-dead-nettle
- Kanadys, W., Baranska, A., Blaszczuk, A., Polz-Dacewicz, M. and others (2021) 'Evaluation of Clinical Meaningfulness of Red Clover (Trifolium pratense L.) Extract to Relieve Hot Flushes and Menopausal Symptoms in Peri- and Post-Menopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials', Nutrients, 13(4), pp. 1258. doi:10.3390/nu13041258 Meta-analysis / review
https://doi.org/10.3390/nu13041258 - Kanadys, W., Baranska, A., Jedrych, M., Religioni, U. and others (2019) 'Effects of red clover (Trifolium pratense) isoflavones on the lipid profile of perimenopausal and postmenopausal women-A systematic review and meta-analysis', Maturitas, 132, pp. 7-16. doi:10.1016/j.maturitas.2019.11.001 Meta-analysis / review
https://doi.org/10.1016/j.maturitas.2019.11.001 - Yokoyama, S.I., Kodera, M., Hirai, A., Nakada, M. and others (2020) 'Red Clover (Trifolium pratense L.) Sprout Prevents Metabolic Syndrome', Journal of Nutritional Science and Vitaminology, 66(1), pp. 48-53. doi:10.3177/jnsv.66.48 Preclinical
https://doi.org/10.3177/jnsv.66.48 - Gosciniak, A., Szulc, P., Zielewicz, W., Walkowiak, J. and others (2023) 'Multidirectional Effects of Red Clover (Trifolium pratense L.) in Support of Menopause Therapy', Molecules, 28(13), pp. 5178. doi:10.3390/molecules28135178 Meta-analysis / review
https://doi.org/10.3390/molecules28135178 - Booth, N.L., Piersen, C.E., Banuvar, S., Geller, S.E. and others (2006) 'Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review', Menopause, 13(2), pp. 251-264. doi:10.1097/01.gme.0000198297.40269.f7 Meta-analysis / review
https://doi.org/10.1097/01.gme.0000198297.40269.f7 - Oza, M.J. and Kulkarni, Y.A (2020) 'Trifolium pratense (Red Clover) Improves SIRT1 Expression and Glycogen Content in High Fat Diet-Streptozotocin Induced Type 2 Diabetes in Rats', Chemistry & Biodiversity, 17(4), pp. e2000019. doi:10.1002/cbdv.202000019 Preclinical
https://doi.org/10.1002/cbdv.202000019 - Circosta, C., De Pasquale, R., Palumbo, D.R., Samperi, S. and others (2006) 'Effects of isoflavones from red clover (Trifolium pratense) on skin changes induced by ovariectomy in rats', Phytotherapy Research, 20(12), pp. 1096-1099. doi:10.1002/ptr.2017 Preclinical
https://doi.org/10.1002/ptr.2017 - Brandli, A., Simpson, J.S. and Ventura, S (2010) 'Isoflavones isolated from red clover (Trifolium pratense) inhibit smooth muscle contraction of the isolated rat prostate gland', Phytomedicine, 17(11), pp. 895-901. doi:10.1016/j.phymed.2010.05.006 Preclinical
https://doi.org/10.1016/j.phymed.2010.05.006 - Burdette, J.E., Liu, J., Lantvit, D., Lim, E. and others (2002) 'Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats', The Journal of Nutrition, 132(1), pp. 27-30. doi:10.1093/jn/132.1.27 Preclinical
https://doi.org/10.1093/jn/132.1.27 - Jiang, Y.B. and Yang, Y.R (2016) 'Trifolium pratense isoflavones improve pulmonary vascular remodelling in broiler chickens', Journal of Animal Physiology and Animal Nutrition, 100(6), pp. 1159-1168. doi:10.1111/jpn.12424 Preclinical
https://doi.org/10.1111/jpn.12424 - Yigit, E. and Unsal, S (2024) 'Isoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial', Climacteric, 27(6), pp. 548-554. doi:10.1080/13697137.2024.2393121 Randomized trial
https://doi.org/10.1080/13697137.2024.2393121 - Lethaby, A.E., Brown, J., Marjoribanks, J., Kronenberg, F., Roberts, H. and Eden, J (2007) 'Phytoestrogens for vasomotor menopausal symptoms', Cochrane Database of Systematic Reviews, (4), pp. CD001395. doi:10.1002/14651858.CD001395.pub3 Meta-analysis / review
https://doi.org/10.1002/14651858.CD001395.pub3 - Geller, S.E. and Studee, L (2006) 'Soy and red clover for mid-life and aging', Climacteric, 9(4), pp. 245-263. doi:10.1080/13697130600736934 Meta-analysis / review
https://doi.org/10.1080/13697130600736934 - Atkinson, C. et al (2004) 'The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial', 79(2), pp. 326--333. doi:10.1093/ajcn/79.2.326 Randomized trial
https://doi.org/10.1093/ajcn/79.2.326 - Quah, Y., Yi-Le, J.C., Park, N.H., Lee, Y.Y., Lee, E.B., Jang, S.H., Kim, M.J., Rhee, M.H., Lee, S.J. and Park, S.C (2022) 'Serum biomarker-based osteoporosis risk prediction and the systemic effects of Trifolium pratense ethanolic extract in a postmenopausal model', Chinese Medicine, 17(1), pp. 70. doi:10.1186/s13020-022-00622-7 Preclinical
https://doi.org/10.1186/s13020-022-00622-7 - Mohsen, A. and Fatemeh, K. and Leila, N. and Mona, P. and Mohammad, Z. and Mozafar, K (2021) 'Pharmacological and therapeutic properties of the Red Clover (Trifolium pratense L.): an overview of the new finding', J Tradit Chin Med, 41(4), pp. 642-649. doi:10.19852/j.cnki.jtcm.20210324.001 Meta-analysis / review
https://doi.org/10.19852/j.cnki.jtcm.20210324.001 - Antonescu Mintas, A.I. and Miere Groza, F. and Fritea, L. and Ganea, M. and Zdrinca, M. and Dobjanschi, L. and Antonescu, A. and Vicas, S.I. and Bodog, F. and Sindhu, R.K. and Cavalu, S (2021) 'Perspectives on the Combined Effects of Trifolium pratense and Ocimum basilicum Extracts in Terms of Phytochemical Profile and Pharmacological Effects', Plants (Basel), 10(7). doi:10.3390/plants10071390 Meta-analysis / review
https://doi.org/10.3390/plants10071390 - Tanrıverdi, G. and Abdulova, A. and Çölgeçen, H. and Atar, H. and Kaleci, B. and Ekiz-Yılmaz, T (2023) 'Investigation of apoptotic and antiproliferative effects of Turkish natural tetraploid Trifolium pratense L. extract on C6 glioblastoma cells via light and electron microscopy', Ultrastruct Pathol, 47(3), pp. 160-171. doi:10.1080/01913123.2023.2184893 Preclinical
https://doi.org/10.1080/01913123.2023.2184893 - Zakłos-Szyda, M. and Budryn, G (2020) 'The Effects of Trifolium pratense L. Sprouts' Phenolic Compounds on Cell Growth and Migration of MDA-MB-231, MCF-7 and HUVEC Cells', Nutrients, 12(1). doi:10.3390/nu12010257 Preclinical
https://doi.org/10.3390/nu12010257 - Khazayel, S. and Faraji, M.H. and Akbaribazm, M. and Khazaei, M. and Niromand, E. and Khazaei, M.R (2025) 'Synergistic inhibitory effects of Trifolium pratense L. extract and doxorubicin on 4T1 tumor-bearing mice are mediated via targeting the Wnt/beta-catenin pathway and reversal of epithelial-mesenchymal transition', Avicenna J Phytomed, 15(5), pp. 1546-1561. doi:10.22038/ajp.2025.25940 Preclinical
https://doi.org/10.22038/ajp.2025.25940 - Shirani Asl, V. and Rafieemehr, H. and Tamaddon, G (2024) 'The impact of Trifolium pratense extract on apoptosis and autophagy in NALM-6 cells: implications for B-ALL intervention', Med Oncol, 41(11), pp. 257. doi:10.1007/s12032-024-02485-4 Preclinical
https://doi.org/10.1007/s12032-024-02485-4 - Won, J.P. and Kim, E. and Hur, J. and Lee, H.G. and Lee, W.J. and Seo, H.G (2023) 'Red clover (Trifolium pratense L.) extract inhibits ferroptotic cell death by modulating cellular iron homeostasis', J Ethnopharmacol, 308, pp. 116267. doi:10.1016/j.jep.2023.116267 Preclinical
https://doi.org/10.1016/j.jep.2023.116267 - Al-Shami, A.S. and Essawy, A.E. and Elkader, H.A.E.A (2023) 'Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen-isoflavones in neurodegenerative disorders', Phytother Res, 37(6), pp. 2693-2737. doi:10.1002/ptr.7870 Meta-analysis / review
https://doi.org/10.1002/ptr.7870 - Zhang, H. and Zhao, J. and Shang, H. and Guo, Y. and Chen, S (2020) 'Extraction, purification, hypoglycemic and antioxidant activities of red clover (Trifolium pratense L.) polysaccharides', Int J Biol Macromol, 148, pp. 750-760. doi:10.1016/j.ijbiomac.2020.01.194 Preclinical
https://doi.org/10.1016/j.ijbiomac.2020.01.194 - Khazaei, A.H. and Bozorgi, A. and Ghanbari, E. and Bozorgi, M. and Khazaei, M (2025) 'Trifolium pratense-Derived Exosome Improved Serum Biochemical Parameters and Pancreatic Genes in STZ-Induced Diabetic Rats', Endocrinol Diabetes Metab, 8(5), pp. e70103. doi:10.1002/edm2.70103 Preclinical
https://doi.org/10.1002/edm2.70103 - Hitzman, R. and Malca-Garcia, G.R. and Howell, C. and Park, H.Y. and Friesen, J.B. and Dong, H. and Dunlap, T. and McAlpine, J.B. and Vollmer, G. and Bosland, M.C. and Nikolić, D. and Lankin, D.C. and Chen, S.N. and Bolton, J.L. and Pauli, G.F. and Dietz, B.M (2023) 'DESIGNER fraction concept unmasks minor bioactive constituents in red clover (Trifolium pratense L.)', Phytochemistry, 214, pp. 113789. doi:10.1016/j.phytochem.2023.113789 Preclinical
https://doi.org/10.1016/j.phytochem.2023.113789 - Lien, Y.Y. and Shyur, L.F. and Cheng, Y.B. and Chang, M.T. and Chang, C.T. and Chen, Y.H. and Lai, G.H. and Liao, H.Y. and Cheng, M.C (2024) 'Trifolium pratense as a novel phytogenic supplement, is an anticoccidial agent in chickens', Poult Sci, 103(10), pp. 104064. doi:10.1016/j.psj.2024.104064 Preclinical
https://doi.org/10.1016/j.psj.2024.104064 - Lee, S.G. and Brownmiller, C. and Lee, S. and Kang, H.W (2020) 'Anti-Inflammatory and Antioxidant Effects of Anthocyanins of Trifolium pratense (Red Clover) in Lipopolysaccharide-Stimulated RAW-267.4 Macrophages', Nutrients, 12(4), pp. 1089-1089. doi:10.3390/nu12041089 Preclinical
https://doi.org/10.3390/nu12041089 - Akbaribazm, M. and Khazaei, M.R. and Khazaei, M.R. and Khazaei, M. and Khazaei, M (2020) 'Phytochemicals and antioxidant activity of alcoholic/hydroalcoholic extract of Trifolium pratense', Chinese Herbal Medicines, 12(3), pp. 326-335. doi:10.1016/j.chmed.2020.02.002 Preclinical
https://doi.org/10.1016/j.chmed.2020.02.002 - Fu, X. and Qin, T. and Yu, J. and Jiao, J. and Ma, Z. and Fu, Q. and Deng, X. and Ma, S (2019) 'Formononetin Ameliorates Cognitive Disorder via PGC-1α Pathway in Neuroinflammation Conditions in High-Fat Diet-Induced Mice', CNS & Neurological Disorders - Drug Targets, 18(7), pp. 566-577. doi:10.2174/1871527318666190807160137 Preclinical
https://doi.org/10.2174/1871527318666190807160137 - Singh, L. and Kaur, H. and Arya, G.C. and Bhatti, R (2023) 'Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen', Chemical Biology & Drug Design, 103(1), pp. e14353-e14353. doi:10.1111/cbdd.14353 Meta-analysis / review
https://doi.org/10.1111/cbdd.14353 - Tan, J.W. and Kim, M (2016) 'Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway', Molecules, 21(5), pp. 548-548. doi:10.3390/molecules21050548 Preclinical
https://doi.org/10.3390/molecules21050548 - Bai, Y. and Li, Z. and Liu, W. and Gao, D. and Liu, M. and Zhang, P (2019) 'Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway', Acta Cirúrgica Brasileira, 34(11), pp. e201901104-e201901104. doi:10.1590/s0102-865020190110000004 Preclinical
https://doi.org/10.1590/s0102-865020190110000004 - Félix, F.B. and Vago, J.P. and Fernandes, D.D.O. and Martins, D.G. and Zaidan, I. and Gonçalves, W.A. and Costa, W.C. and Araújo, J.M.D. and Queiroz‐Junior, C.M. and Campolina-Silva, G.H. and Soriani, F.M. and Sousa, L.P. and Grespan, R. and Teixeira, M.M. and Pinho, V (2021) 'Biochanin A Regulates Key Steps of Inflammation Resolution in a Model of Antigen-Induced Arthritis via GPR30/PKA-Dependent Mechanism', Frontiers in Pharmacology, 12, pp. 662308-662308. doi:10.3389/fphar.2021.662308 Preclinical
https://doi.org/10.3389/fphar.2021.662308 - Akbaribazm, M. and Khazaei, M.R. and Khazaei, M.R. and Khazaei, M. and Khazaei, M (2020) 'Trifolium pratense L. (red clover) extract and doxorubicin synergistically inhibits proliferation of 4T1 breast cancer in tumor‐bearing BALB/c mice through modulation of apoptosis and increase antioxidant and anti‐inflammatory related pathways', Food Science & Nutrition, 8(8), pp. 4276-4290. doi:10.1002/fsn3.1724 Preclinical
https://doi.org/10.1002/fsn3.1724 - Akbaribazm, M. and Khazaei, M.R. and Khazaei, M.R. and Khazaei, F. and Khazaei, M. and Khazaei, M (2020) 'Doxorubicin and Trifolium pratense L. (Red clover) extract synergistically inhibits brain and lung metastases in 4T1 tumor‐bearing BALB/c mice', Food Science & Nutrition, 8(10), pp. 5557-5570. doi:10.1002/fsn3.1820 Preclinical
https://doi.org/10.1002/fsn3.1820 - Khazaei, M. and Pazhouhi, M (2018) 'Antiproliferative Effect of Trifolium Pratens L. Extract in Human Breast Cancer Cells', Nutrition and Cancer, 71(1), pp. 128-140. doi:10.1080/01635581.2018.1521443 Preclinical
https://doi.org/10.1080/01635581.2018.1521443 - Pazhouhi, M. and Khazaei, M (2018) 'Protective effect of hydroalcoholic extracts of Trifolium pratense L. on pancreatic β cell line (RIN-5F) against cytotoxicty of streptozotocin', Research in Pharmaceutical Sciences, 13(4), pp. 324-324. doi:10.4103/1735-5362.235159 Preclinical
https://doi.org/10.4103/1735-5362.235159 - Antonescu, I.A. and Antonescu, A. and Miere, F. and Fritea, L. and Teușdea, A.C. and Vicaș, L.G. and Vicaş, S.I. and Brihan, I. and Domuța, M. and Zdrîncă, M. and Zdrîncă, M. and Cavalu, S (2021) 'Evaluation of Wound Healing Potential of Novel Hydrogel Based on Ocimum basilicum and Trifolium pratense Extracts', Processes, 9(11), pp. 2096-2096. doi:10.3390/pr9112096 Preclinical
https://doi.org/10.3390/pr9112096 - British Herbal Medicine Association (1996) 'British Herbal Pharmacopoeia'. Traditional / reference
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https://scholar.google.com/scholar?q=Medical%20Herbalism - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Booth, N.L., Piersen, C.E., Banuvar, S., Geller, S.E., Shulman, L.P. and Farnsworth, N.R (2006) 'Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review', Menopause, 13(2), pp. 251-264. doi:10.1097/01.gme.0000198297.40269.f7 Meta-analysis / review
https://doi.org/10.1097/01.gme.0000198297.40269.f7 - Fritz, H., Seely, D., Flower, G., Skidmore, B., Fernandes, R., Vadeboncoeur, S., Kennedy, D., Cooley, K., Wong, R., Sagar, S., Sabri, E. and Fergusson, D (2013) 'Soy, red clover, and isoflavones and breast cancer: a systematic review', PLoS One, 8(11), pp. e81968. doi:10.1371/journal.pone.0081968 Meta-analysis / review
https://doi.org/10.1371/journal.pone.0081968
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.