Symptom → Plant Sources
White Dead Nettle (Lamium album) as a tool for helping with Arthritis / joint pain
inferred from anti-inflammatory action
← Back to Symptom-to-Plant Lookup
Full White Dead Nettle monograph →All plants for arthritis / joint pain →
Background : As part of the efforts to find natural alternatives for cancer treatment and to overcome the barriers of cellular resistance to chemotherapeutic agents, polymeric nanocapsules containing curcumin and/or methotrexate were prepared by an interfacial deposition of preformed polymer method. Methods : Physicochemical properties, drug release experiments and in vitro cytotoxicity of these nanocapsules were performed against the Calu-3 lung cancer cell line. Results : The colloidal suspensions of nanocapsules showed suitable size (287 to 325 nm), negative charge (-33 to -41 mV) and high encapsulation efficiency (82.4 to 99.4%). Spherical particles at nanoscale dimensions were observed by scanning electron microscopy. X-ray diffraction analysis indicated that nanocapsules exhibited a non-crystalline pattern with a remarkable decrease of crystalline peaks of the raw materials. Fourier-transform infrared spectra demonstrated no chemical bond between the drug(s) and polymers. Drug release experiments evidenced a controlled release pattern with no burst effect for nanocapsules containing curcumin and/or methotrexate. The nanoformulation containing curcumin and methotrexate (NCUR/MTX-2) statistically decreased the cell viability of Calu-3. The fluorescence and morphological analyses presented a predominance of early apoptosis and late apoptosis as the main death mechanisms for Calu-3. Conclusions : Curcumin and methotrexate co-loaded nanocapsules can be further used as a novel therapeutic strategy for treating non-small-cell lung cancer.
4 sources supporting White Dead Nettle for Arthritis / joint pain. Includes scientific publications, books, monographs and traditional-use references.
Mechanistic basis
This use is associated with the plant's anti-inflammatory action. Further evidence for that pharmacology:
Bioassay-guided isolation from Lamium album aerial parts yielded iridoids and phenylpropanoids that inhibited reactive oxygen species and elastase release in human neutrophils, supporting the anti-inflammatory and antiseptic traditional use of white dead-nettle in bronchitis and pharyngitis.
Constituents isolated from an aqueous-methanolic extract of Lamium album herb inhibited pro-inflammatory cytokine (IL-8, TNF-alpha) secretion in human neutrophils, providing a mechanistic basis for the traditional anti-inflammatory use of white dead-nettle.
In a rat middle-cerebral-artery-occlusion stroke model, Lamium album extract modulated caspase-3 and cyclooxygenase-2 gene expression, indicating a potential anti-inflammatory and anti-apoptotic effect of white dead-nettle.