Plant Comparison
Dill vs Japanese knotweed
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Dill and Japanese knotweed: they share 5 indicated uses (arthritis / joint pain, cancer (anticancer research), cardiovascular / heart health, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Dill | Japanese knotweed | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 8/10 | 2/10 | Stronger for Dill |
| Cancer (anticancer research) | 2/10 | 2/10 | Comparable evidence |
| Cardiovascular / heart health | 8/10 | 1/10 | Stronger for Dill |
| Inflammation (general) | 8/10 | 7/10 | Comparable evidence |
| Skin irritation | 8/10 | 1/10 | Stronger for Dill |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Seed essential oil dominated by the monoterpene ketone carvone and limonene, giving dill its characteristic aroma and much of its carminative and antimicrobial activity.
Antioxidant flavonoids and phenolics identified in metabolomic analysis of leaf and seed extracts.
Considered the principal bioactive constituents, responsible for much of the antioxidant, anti-inflammatory and cardioprotective activity attributed to this root.
Emodin has laxative and anti-inflammatory activity at typical concentrations but can cause gastrointestinal upset at high doses.
Pharmacological Actions
Anethum graveolens (dill) extract and essential oil induce ROS-mediated apoptosis in melanoma and lung adenocarcinoma cells (preclinical).
Traditional & Indicated Uses
inferred from anti-inflammatory action
Anethum graveolens (dill) extract induces ROS-mediated apoptosis in HT-144 melanoma cells, and its essential oil is selectively cytotoxic and pro-apoptotic against A549 lung adenocarcinoma cells (preclinical).
inferred from digestive action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from diuretic action
inferred from diuretic action
inferred from diuretic action
inferred from anti-inflammatory action
inferred from anticancer action
inferred from anti-inflammatory action
Safety, Cautions & Contraindications
Widely used as a food herb/spice; WHO monograph notes a “generally regarded as safe” status as a flavouring agent (World Health Organization, 2007). Allergic reactions (including oral itching, swelling, urticaria, vomiting/diarrhoea) are reported; avoid if you react to Apiaceae-family plants (World Health Organization, 2007; Egyptian Drug Authority, n.d.).
Duke (2002) provides clinical evidence (score 2) for dill's antibacterial and antispasmodic activities, consistent with Commission E and PhEur approvals. Traditional uses include management of colic, dyspepsia, and flatulence. The plant is a well-documented lactagogue (promotes milk production) and has a mild hypotensive effect. Dose: 1–3 g seeds as tea three times daily. Dill is generally safe (++) with no known significant contraindications at culinary and medicinal doses (Duke, 2002).
Japanese knotweed root contains resveratrol and emodin; high doses of emodin may cause GI discomfort and have laxative effects. Not recommended during pregnancy (emodin has potential teratogenic effects in animal studies). May interact with anticoagulants and antiplatelet medications. Quality control of commercial preparations is important as invasive weed extracts vary significantly.
Duke (2002) rates Japanese knotweed (listed as Hu-Zhang, Fallopia japonica) as +++ and highlights its rich content of resveratrol and emodin. Experimental evidence (score 1) supports COX-2 inhibitory, antioxidant, anti-inflammatory, hepatoprotective, and lipid-lowering activities — largely attributed to resveratrol. Duke notes its use in traditional Chinese medicine for fractures, burns, abscesses, and gynecological conditions. No significant clinical trials were available at time of publication, but resveratrol's biological activity is well-documented in vitro (Duke, 2002).
External Ids
Botanical Description
Aromatic annual herb with a slender, hollow, ridged, blue-green stem. The leaves are finely divided into thread-like segments, feathery and soft, similar to fennel but more delicate. Small yellow flowers are borne in flat, wide compound umbels at the stem tips in summer, ripening into flattened, ridged, aromatic seeds (fruits).[1]
Vigorous, invasive rhizomatous perennial (Polygonaceae) with hollow, bamboo-like, jointed stems 1-3 m tall (occasionally taller), speckled reddish-purple. Leaves are broad, heart- to shovel-shaped with a flat base. Abundant sprays of small, creamy-white flowers appear in late summer, followed by small winged fruit.[6]
Habitat
Believed native to the eastern Mediterranean, Western Asia and southern Russia; widely cultivated as a culinary and medicinal herb in gardens and fields across Europe, Asia and the Americas.[1]
Native to East Asia (Japan, China, Korea), now a notorious invasive species across Europe and North America, growing in disturbed ground, riverbanks, roadsides and waste land, spreading aggressively via an extensive rhizome network.[6]
Harvesting
Leaves are picked fresh through the growing season; the seeds are harvested in late summer once the umbels have browned and dried, then threshed and dried further before storage.
The rhizome/root, the main medicinal part, is dug in autumn or winter when resveratrol content is highest; young spring shoots (stems) are also edible and used. Strict containment is required when harvesting, given the plant's severe invasiveness.[6]
Traditional Uses
Dill seed and leaf have a long culinary-medicinal history as a carminative digestive remedy for colic, dyspepsia and flatulence, and as a traditional lactagogue (galactagogue) to support breastfeeding; dill water ('gripe water') is a classic infant remedy for colic.[1]
Known as Hu Zhang in Traditional Chinese Medicine, Japanese knotweed root has a centuries-old use for inflammation, infections, jaundice and menstrual complaints. Modern interest centres on its resveratrol and emodin content, now studied (as Polygonum cuspidatum extract) for antioxidant, anti-inflammatory, cardioprotective and hepatoprotective activity, and more recently for supportive use in acute respiratory infections.[2, 3, 6]
Preparations
Dosage
The WHO monograph on Fructus Anethi gives an average daily dose of 3 g of the dried ripe fruit, or 0.1-0.3 g of the essential oil, or the equivalent in other preparations. Educational reference only, not a prescription.
Duke (2002) and general phytotherapy guidance treat this as an experimentally supported herb without a single agreed clinical dose; commercial resveratrol-standardised extracts should be dosed per product labelling. Educational reference only, not a prescription; avoid in pregnancy.
References
Lookalikes Review
Dangerous Lookalikes
Not documented
References & Sources
- Thanuma, J., Phetcharaburanin, J., Dokduang, H., Loilome, W. and others (2025) 'Metabolomic analysis of bioactive compounds in dill (Anethum graveolens L.) extracts', PeerJ, 13, pp. e19567. doi:10.7717/peerj.19567 Preclinical
https://doi.org/10.7717/peerj.19567 - Sharma, H., Yang, H., Sharma, N. and An, S.S.A (2024) 'Neuroprotection by Anethum graveolens (Dill) Seeds and Its Phytocompounds in SH-SY5Y Neuroblastoma Cell Lines and Acellular Assays', International Journal of Molecular Sciences, 25(13), pp. 7104. doi:10.3390/ijms25137104 Preclinical
https://doi.org/10.3390/ijms25137104 - Mohammed, F.A., Elkady, A.I., Syed, F.Q., Mirza, M.B. and others (2018) 'Anethum graveolens (dill) - A medicinal herb induces apoptosis and cell cycle arrest in HepG2 cell line', Journal of Ethnopharmacology, 219, pp. 15-22. doi:10.1016/j.jep.2018.03.008 Preclinical
https://doi.org/10.1016/j.jep.2018.03.008 - Haidari, F., Zakerkish, M., Borazjani, F., Ahmadi Angali, K. and others (2020) 'The effects of Anethum graveolens (dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes', Trials, 21(1), pp. 483. doi:10.1186/s13063-020-04401-3 Randomized trial
https://doi.org/10.1186/s13063-020-04401-3 - Li, Z., Xue, Y., Li, M., Guo, Q. and others (2018) 'The Antioxidation of Different Fractions of Dill (Anethum graveolens) and Their Influences on Cytokines in Macrophages RAW264.7', Journal of Oleo Science, 67(12), pp. 1535-1541. doi:10.5650/jos.ess18134 Preclinical
https://doi.org/10.5650/jos.ess18134 - Jang, S.A., Lee, S.J., Hwang, Y.H. and Ha, H (2023) 'Anti-Osteoporotic Potential of Water Extract of Anethum graveolens L. Seeds', Nutrients, 15(19), pp. 4302. doi:10.3390/nu15194302 Preclinical
https://doi.org/10.3390/nu15194302 - Stavri, M. and Gibbons, S (2005) 'The antimycobacterial constituents of dill (Anethum graveolens)', Phytotherapy Research, 19(11), pp. 938-941. doi:10.1002/ptr.1758 Preclinical
https://doi.org/10.1002/ptr.1758 - Orhan, I.E., Senol, F.S., Ozturk, N., Celik, S.A. and others (2013) 'Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L. (dill) samples cultivated under organic and conventional agricultural conditions', Food and Chemical Toxicology, 59, pp. 96-103. doi:10.1016/j.fct.2013.05.053 Preclinical
https://doi.org/10.1016/j.fct.2013.05.053 - Tian, J., Ban, X., Zeng, H., He, J. and others (2012) 'The mechanism of antifungal action of essential oil from dill (Anethum graveolens L.) on Aspergillus flavus', PLoS One, 7(1), pp. e30147. doi:10.1371/journal.pone.0030147 Preclinical
https://doi.org/10.1371/journal.pone.0030147 - Castro, L.M., Pinto, N.B., Moura, M.Q., Villela, M.M. and others (2021) 'Antihelminthic action of the Anethum graveolens essential oil on Haemonchus contortus eggs and larvae', Brazilian Journal of Biology, 81(1), pp. 183-188. doi:10.1590/1519-6984.225856 Preclinical
https://doi.org/10.1590/1519-6984.225856 - World Health Organization (2007) 'Fructus Anethi'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Egyptian Drug Authority (n.d.). Available at: https://dev.edaegypt.gov.eg/media/a4kf0fmp/anethum-graveolens_1.pdf Traditional / reference
https://dev.edaegypt.gov.eg/media/a4kf0fmp/anethum-graveolens_1.pdf - Haidari, F., Mohammadshahi, M., Zarei, M., Gorji, Z., Asghari-Jafarabadi, M. and Alizadeh, M (2020) 'The effects of anethum graveolens (dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes'. doi:10.1016/j.ctim.2020.102367 Randomized trial
https://doi.org/10.1016/j.ctim.2020.102367 - Mousavi, S.M., Pizarro, A.B., Akhgarjand, C., Bagheri, A., Persad, E., Karimi, E., Wong, A. and Jayedi, A (2022) 'The effects of Anethum graveolens (dill) supplementation on lipid profile and glycemic control: a systematic review and meta-analysis of randomized controlled trials', 62(21), pp. 5705--5716. doi:10.1080/10408398.2021.1889459 Meta-analysis / review
https://doi.org/10.1080/10408398.2021.1889459 - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:837530-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:837530-1 - World Health Organization (2007) 'WHO monographs on selected medicinal plants, Volume 3: ‘Fructus Anethi'. Available at: https://e-lactancia.org/media/papers/Fitoterapia-Plantas-WHO-03_2007.pdf Traditional / reference
https://e-lactancia.org/media/papers/Fitoterapia-Plantas-WHO-03_2007.pdf - Aydogmus-Ozturk, F. and Jahan, H. and Ozturk, M. and Gunaydin, K. and Choudhary, M.I (2020) 'Preclinical study of the medicinal plants for the treatment of malignant melanoma', Molecular Biology Reports, 47(8), pp. 5975-5983. doi:10.1007/s11033-020-05671-5 Preclinical
https://doi.org/10.1007/s11033-020-05671-5 - Tavakkol Afshari, H.S. and Homayouni Tabrizi, M. and Ardalan, T. and Jalili Anoushirvani, N. and Mahdizadeh, R (2021) 'Anethum graveolens Essential Oil Nanoemulsions (AGEO-NE) as an Exclusive Apoptotic Inducer in Human Lung Adenocarcinoma (A549) Cells', Nutrition and Cancer, 74(4), pp. 1411-1419. doi:10.1080/01635581.2021.1952450 Preclinical
https://doi.org/10.1080/01635581.2021.1952450 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Washington State University Extension, Yakima County (2025) 'One Invasive, One Native, Both Deadly'. Available at: https://extension.wsu.edu/yakima/2025/08/09/one-invasive-one-native-both-deadly/ Traditional / reference
https://extension.wsu.edu/yakima/2025/08/09/one-invasive-one-native-both-deadly/ - King County Noxious Weeds (2024) 'Poison hemlock (Conium maculatum) identification and control'. Available at: https://kingcounty.gov/en/dept/dnrp/nature-recreation/environment-ecology-conservation/noxious-weeds/identification-control/poison-hemlock Traditional / reference
https://kingcounty.gov/en/dept/dnrp/nature-recreation/environment-ecology-conservation/noxious-weeds/identification-control/poison-hemlock - Dayan, A.D (2024) 'Death of Socrates: a likely case of poison hemlock (Conium maculatum) poisoning', Clinical Toxicology (Philadelphia, Pa.), 62(1), pp. 56-60. doi:10.1080/15563650.2024.2309328 Clinical study
https://doi.org/10.1080/15563650.2024.2309328 - Grow Forage Cook Ferment 'Poison Hemlock: How to Identify and Potential Look-alikes'. Available at: https://www.growforagecookferment.com/poison-hemlock/ Traditional / reference
https://www.growforagecookferment.com/poison-hemlock/
- Dong, X., Fu, J., Yin, X., Cao, S. and others (2016) 'Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics', Phytotherapy Research, 30(8), pp. 1207-1218. doi:10.1002/ptr.5631 Traditional / reference
https://doi.org/10.1002/ptr.5631 - Wang, S., Yang, Y., Sun, L., Qiao, G. and others (2022) 'Reynoutria japonica Houtt for Acute Respiratory Tract Infections in Adults and Children: A Systematic Review', Frontiers in Pharmacology, 13, pp. 787032. doi:10.3389/fphar.2022.787032 Meta-analysis / review
https://doi.org/10.3389/fphar.2022.787032 - Ke, Y., Zhan, L., Lu, T., Zhou, C. and others (2023) 'Advances for pharmacological activities of Polygonum cuspidatum (Reynoutria japonica) - A review', Pharmaceutical Biology, 61(1), pp. 177-188. doi:10.1080/13880209.2022.2158349 Traditional / reference
https://doi.org/10.1080/13880209.2022.2158349 - Zhang, Q., Zhao, Y., Zhang, M., Zhang, Y. and others (2021) 'Bioactive amides from Reynoutria japonica', Journal of Asian Natural Products Research, 23(3), pp. 228-234. doi:10.1080/10286020.2021.1873298 Preclinical
https://doi.org/10.1080/10286020.2021.1873298 - Lai, Y., Zhou, C., Huang, P., Dong, Z. and others (2024) 'Polygonum cuspidatum polysaccharide: A review of its extraction and purification, structure analysis, and biological activity', Journal of Ethnopharmacology, 331, pp. 118079. doi:10.1016/j.jep.2024.118079 Traditional / reference
https://doi.org/10.1016/j.jep.2024.118079 - Peng, W., Qin, R., Li, X. and Zhou, H (2013) 'Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Sieb. et Zucc.: a review', Journal of Ethnopharmacology, 148(3), pp. 729-745. doi:10.1016/j.jep.2013.05.007 Traditional / reference
https://doi.org/10.1016/j.jep.2013.05.007 - Wang, X., Liang, L., Yan, J., Li, Z. and others (2023) 'Citri Reticulatae Pericarpium-Reynoutria japonica Houtt. herb pair suppresses breast cancer liver metastasis by targeting ECM1-mediated cholesterol biosynthesis pathway', Phytomedicine, 116, pp. 154896. doi:10.1016/j.phymed.2023.154896 Preclinical
https://doi.org/10.1016/j.phymed.2023.154896 - Jiang, Y., Liu, Y., Zhang, X. and others (2020) 'New phenolic glycosides from Reynoutria japonica', Journal of Asian Natural Products Research, 22(1), pp. 17-23. doi:10.1080/10286020.2019.1646730 Preclinical
https://doi.org/10.1080/10286020.2019.1646730 - Liu, Y., Wang, J., Li, Q. and others (2024) 'The Possibility of Polygonum cuspidatum against Osteoarthritis based on Network Pharmacology', Current Computer-Aided Drug Design, 20(2), pp. 121-133. doi:10.2174/1573409919666230403114131 Preclinical
https://doi.org/10.2174/1573409919666230403114131 - Espinosa-Andrews, H., Morales-Hernandez, N., Garcia-Marquez, E. and others (2025) 'Physicochemical and rheological characteristics of commercial Greek-style yogurt enriched with Polygonum cuspidatum roots or the P. cuspidatum beta-cyclodextrin inclusion complex', Food Research International, 203, pp. 115854. doi:10.1016/j.foodres.2025.115854 Preclinical
https://doi.org/10.1016/j.foodres.2025.115854 - Burns, J., Yokota, T., Ashihara, H., Lean, M.E.J. and Crozier, A (2002) 'Plant foods and herbal sources of resveratrol', 50(11), pp. 3337--3340. doi:10.1021/jf0112973 Traditional / reference
https://doi.org/10.1021/jf0112973 - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - World Health Organization (2007) 'WHO Monographs on Selected Medicinal Plants'. Traditional / reference
https://scholar.google.com/scholar?q=WHO%20Monographs%20on%20Selected%20Medicinal%20Plants - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.