Omnia SanaPlant Comparison
Lady’s-mantle vs Raspberry Leaf
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Lady’s-mantle and Raspberry Leaf: both belong to the Rosaceae family; they share 3 indicated uses (menstrual cramps, skin irritation, wounds).
Evidence face-off — shared uses
| Condition | Lady’s-mantle | Raspberry Leaf | Verdict |
|---|---|---|---|
| Menstrual cramps | 1/10 | 5/10 | Stronger for Raspberry Leaf |
| Skin irritation | 2/10 | 6/10 | Stronger for Raspberry Leaf |
| Wounds | 1/10 | 5/10 | Stronger for Raspberry Leaf |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Lady's mantle is rich in ellagitannins and other tannins (the basis of its astringency) together with phenolic acids (gallic and caffeic acids) and flavonoids such as quercetin and catechin, which underlie its antioxidant activity.
Pharmacological Actions
Alchemilla vulgaris extracts (aerial parts and root) show antioxidant, genoprotective and antitumor activity against multiple human cancer cell lines (preclinical).
Astringent for mild diarrhoea (tannins)
Astringent for menstrual cramps (traditional); Astringent for mild diarrhoea (tannins)
Traditional uterine tonic taken in late pregnancy to tone the uterus and support labour - one small double-blind RCT found a shorter second stage of labour and fewer forceps deliveries (no effect on the first stage), alongside observational signals; robust proof is still lacking
Traditional & Indicated Uses
inferred from anti-inflammatory action
Alchemilla vulgaris extracts suppress the growth of MCF-7, A375, A549, HCT116 (aerial parts) and PC-3, MCF-7, Caco-2 (root) cancer cells via caspase-dependent apoptosis and autophagy, while protecting normal cells (preclinical).
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Astringent for menstrual cramps (traditional)
inferred from emmenagogue action
inferred from astringent action
Safety, Cautions & Contraindications
Generally considered very safe. One of the gentlest astringent herbs in European herbalism. No significant drug interactions. Tannin content means very high doses should be avoided in sensitive stomachs. Not significantly contraindicated in pregnancy at normal herbal tea doses, but medicinal doses should be used cautiously.
Duke (2002) rates lady's mantle as ++ and notes astringent, angioprotective, anti-inflammatory, and vulnerary activities at the experimental level (score 1). The plant is rich in tannins and is traditionally used for diarrhea, wound healing, and as a mild gynecological tonic. Duke notes its anti-inflammatory and antioxidant properties as experimentally supported. No significant safety concerns are noted at usual herbal doses; the plant is generally well-tolerated (Duke, 2002).
External Ids
Botanical Description
Low, clump-forming perennial herb with distinctive rounded, softly hairy leaves divided into 7-11 shallow, scalloped, toothed lobes, fanning out like a cloak (giving the genus name Alchemilla, 'little alchemist', after the dew drops that collect in the leaf centre, once prized by alchemists). Tiny, petal-less, yellow-green flowers are borne in loose, branching clusters above the foliage.[14]
Deciduous, thicket-forming shrub (Rosaceae), 1-2 m tall, with upright, prickly, biennial canes (vegetative in the first year, fruiting in the second). Leaves are pinnate with 3-7 toothed leaflets, whitish-felted beneath. Small white, five-petalled flowers are followed by the aggregate red raspberry fruit, a cluster of drupelets.[2]
Habitat
Grows in damp meadows, pastures, mountain grassland, streamsides and open woodland, typically on moist, nutrient-rich soils; native to Europe and parts of temperate Asia, favouring cooler upland and northern regions.[14]
Native to Europe and northern Asia, widely cultivated as a fruit crop and naturalised on woodland edges, hedgerows and disturbed ground in temperate regions.[2]
Harvesting
The leaves and flowering tops are gathered in summer while the plant is in flower, and dried in a warm, shaded, airy place.[14]
Leaves are picked fresh during the growing season - before or during flowering is considered optimal - and dried; fruit is picked when fully ripe in summer.[2]
Traditional Uses
Lady's mantle has long been used in European herbal medicine as a gentle astringent for menstrual complaints and as a mild gynaecological tonic, and topically for minor wounds and skin inflammation, reflecting its tannin-rich astringent character.[15]
Raspberry leaf has a long, very widely known folk tradition as a 'pregnancy tea', taken in the final weeks of pregnancy as a uterine tonic to prepare for labour. Observational studies and a small randomised controlled trial suggest a possible modest effect on labour duration, though robust proof is still lacking.[1, 13]
Preparations
Dried leaf and flowering tops infused in hot water, traditionally taken for menstrual complaints and mild digestive upset.
References
Lookalikes Review
Dosage
Not documented
Popular guidance and observational studies generally describe starting raspberry-leaf tea or tablets in the last few weeks of pregnancy, at roughly 1-3 cups of tea daily; use should be discussed with a midwife or doctor given the lack of robust trial evidence. Educational reference only, not a prescription.
References & Sources
- Jelaca, S., Jovanovic, I., Bovan, D., Jovanovic, M.Z., Jurisevic, M.M., Dundjerovic, D. and others (2024) 'Dual Role of Alchemilla vulgaris L. Extract in Breast Cancer Regression: Reestablishment of Effective Immune Response', Pharmaceuticals, 17(3). doi:10.3390/ph17030286 Preclinical
https://doi.org/10.3390/ph17030286 - Jelaca, S., Jovanovic, I., Bovan, D., Pavlovic, S., Gajovic, N., Dundjerovic, D. and others (2024) 'Antimelanoma Effects of Alchemilla vulgaris: A Comprehensive In Vitro and In Vivo Study', Diseases, 12(6). doi:10.3390/diseases12060125 Preclinical
https://doi.org/10.3390/diseases12060125 - Kanak, S., Krzeminska, B., Celinski, R., Bakalczuk, M. and Dos Santos Szewczyk, K (2022) 'Phenolic composition and antioxidant activity of Alchemilla species', Plants, 11(20), pp. 2709. doi:10.3390/plants11202709 Meta-analysis / review
https://doi.org/10.3390/plants11202709 - Jakimiuk, K. and Tomczyk, M (2023) 'A review of the traditional uses, phytochemistry, pharmacology, and clinical evidence for the use of the genus Alchemilla (Rosaceae)', Journal of Ethnopharmacology, 320, pp. 117439. doi:10.1016/j.jep.2023.117439 Meta-analysis / review
https://doi.org/10.1016/j.jep.2023.117439 - Jelaca, S., Dajic-Stevanovic, Z., Vukovic, N., Kolasinac, S., Trendafilova, A., Nedialkov, P. and others (2022) 'Beyond Traditional Use of Alchemilla vulgaris: Genoprotective and Antitumor Activity In Vitro', Molecules, 27(23). doi:10.3390/molecules27238113 Traditional / reference
https://doi.org/10.3390/molecules27238113 - Anajirih, N., Abdeen, A., Taher, E.S., Abdelkader, A., Abd-Ellatieff, H.A., Gewaily, M.S. and others (2024) 'Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis', Frontiers in Pharmacology. doi:10.3389/fphar.2024.1394557 Preclinical
https://doi.org/10.3389/fphar.2024.1394557 - Karaoglan, E.S., Bayir, Y., Albayrak, A., Toktay, E., Ozgen, U., Kazaz, C., Kahramanlar, A. and Cadirci, E (2020) 'Isolation of major compounds and gastroprotective activity of Alchemilla on indomethacin induced gastric ulcers in rats', Eurasian Journal of Medicine, 52(3), pp. 249-253. doi:10.5152/eurasianjmed.2020.19243 Preclinical
https://doi.org/10.5152/eurasianjmed.2020.19243 - Vlaisavljevic, S., Jelaca, S., Zengin, G., Mimica-Dukic, N., Berezni, S., Miljic, M. and Dajic Stevanovic, Z (2019) 'Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties', RSC Advances, 9(64), pp. 37474--37483. doi:10.1039/c9ra08231j Preclinical
https://doi.org/10.1039/c9ra08231j - Kupeli Akkol, E., Demirel, M.A., Bahadir Acikara, O., Suntar, I., Ergene, B., Ilhan, M., Ozbilgin, S., Saltan, G., Keles, H. and Tekin, M (2015) 'Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model', Archives of Gynecology and Obstetrics, 292(3), pp. 619-628. doi:10.1007/s00404-015-3665-6 Preclinical
https://doi.org/10.1007/s00404-015-3665-6 - Dos Santos Szewczyk, K., Pietrzak, W., Klimek, K., Grzywa-Celinska, A., Celinski, R. and Gogacz, M (2022) 'LC-ESI-MS/MS identification of biologically active phenolics in different extracts of Alchemilla acutiloba Opiz', Molecules, 27(3), pp. 621. doi:10.3390/molecules27030621 Preclinical
https://doi.org/10.3390/molecules27030621 - Ozbek, H., Acikara, O.B., Keskin, I., Kirmizi, N.I., Ozbilgin, S., Oz, B.E., Kurtul, E., Ozrenk, B.C., Tekin, M. and Saltan, G (2016) 'Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis', Biomedicine & Pharmacotherapy, 86, pp. 172-176. doi:10.1016/j.biopha.2016.12.005 Preclinical
https://doi.org/10.1016/j.biopha.2016.12.005 - Krivokuca, M., Niketic, M., Milenkovic, M., Golic, N., Masia, C., Scaltrito, M.M., Sisto, F. and Kundakovic, T (2015) 'Anti-Helicobacter pylori activity of four Alchemilla species (Rosaceae)', Natural Product Communications, 10(8), pp. 1369-1371. doi:10.1177/1934578x1501000814 Preclinical
https://doi.org/10.1177/1934578x1501000814 - Duckstein, S.M., Lotter, E.M., Meyer, U., Lindequist, U. and Stintzing, F.C (2013) 'Phenolic constituents from Alchemilla vulgaris L. and Alchemilla mollis (Buser) Rothm. at different dates of harvest', Zeitschrift fur Naturforschung C, 68(1-2), pp. 529-540. doi:10.1515/znc-2012-11-1201 Preclinical
https://doi.org/10.1515/znc-2012-11-1201 - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Hoffmann, D (2003) 'Medical Herbalism: The Science and Practice of Herbal Medicine'. Traditional / reference
https://scholar.google.com/scholar?q=Medical%20Herbalism%3A%20The%20Science%20and%20Practice%20of%20Herbal%20Medicine - Pauli, A. and Schilcher, H (2012) 'In vitro antimicrobial activities of essential oils monographed in the European Pharmacopoeia 6th edition'. Traditional / reference
https://scholar.google.com/scholar?q=In%20vitro%20antimicrobial%20activities%20of%20essential%20oils%20monographed%20in%20the%20European%20Pharmacopoeia%206th%20edition - Ibrahim, O.H.M. and Abo-Elyousr, K.A.M. and Asiry, K.A. and Alhakamy, N.A. and Mousa, M.A.A (2022) 'Phytochemical Characterization, Antimicrobial Activity and In Vitro Antiproliferative Potential of Alchemilla vulgaris Auct Root Extract against Prostate (PC-3), Breast (MCF-7) and Colorectal Adenocarcinoma (Caco-2) Cancer Cell Lines', Plants, 11(16), pp. 2140. doi:10.3390/plants11162140 Preclinical
https://doi.org/10.3390/plants11162140 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
- Bowman, R.L., Taylor, J. and Davis, D.L (2024) 'Raspberry leaf (Rubus idaeus) use in pregnancy: a prospective observational study', BMC Complementary Medicine and Therapies. doi:10.1186/s12906-024-04465-7 Randomized trial
https://doi.org/10.1186/s12906-024-04465-7 - Mostafa, H.S. and others (2020) 'Phenolic Composition, Mineral Content, and Beneficial Bioactivities of Leaf Extracts from Black Currant (Ribes nigrum L.), Raspberry (Rubus idaeus), and Aronia (Aronia melanocarpa)', Nutrients, 12(2), pp. 463. doi:10.3390/nu12020463 Meta-analysis / review
https://doi.org/10.3390/nu12020463 - Bijak, M., Saluk-Bijak, J. and others (2016) 'The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils', Platelets, 27(5), pp. 433-439. doi:10.3109/09537104.2015.1131254 Preclinical
https://doi.org/10.3109/09537104.2015.1131254 - Valdes, M. and others (2022) 'Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial', BMC Musculoskeletal Disorders, 23(1), pp. 650. doi:10.1186/s12891-022-05612-2 Randomized trial
https://doi.org/10.1186/s12891-022-05612-2 - Campos, P.M. and others (2020) 'Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial', Journal of Cosmetic Dermatology, 19(3), pp. 671-676. doi:10.1111/jocd.13305 Randomized trial
https://doi.org/10.1111/jocd.13305 - Bednarski, M. and others (2014) 'CD39/NTPDase-1 expression and activity in human umbilical vein endothelial cells are differentially regulated by leaf extracts from Rubus caesius and Rubus idaeus', Cellular & Molecular Biology Letters, 19(2), pp. 291-304. doi:10.2478/s11658-014-0202-8 Preclinical
https://doi.org/10.2478/s11658-014-0202-8 - Rojas-Vera, J., Patel, A.V. and Dacke, C.G (2002) 'Relaxant activity of raspberry (Rubus idaeus) leaf extract in guinea-pig ileum in vitro', Phytotherapy Research, 16(7), pp. 665-668. doi:10.1002/ptr.1040 Preclinical
https://doi.org/10.1002/ptr.1040 - Raudone, L. and others (2022) 'In Vitro Antioxidant and Prooxidant Activities of Red Raspberry (Rubus idaeus L.) Stem Extracts', Molecules, 27(13), pp. 4073. doi:10.3390/molecules27134073 Preclinical
https://doi.org/10.3390/molecules27134073 - Cugnetto, M.L. and others (2015) 'An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells', International Journal of Cosmetic Science, 37(4), pp. 428-433. doi:10.1111/ics.12236 Preclinical
https://doi.org/10.1111/ics.12236 - Socha, M.W., Flis, W., Wartega, M., Szambelan, M., Pietrus, M. and Kazdepka-Zieminska, A (2023) 'Raspberry Leaves and Extracts-Molecular Mechanism of Action and Its Effectiveness on Human Cervical Ripening and the Induction of Labor', Nutrients, 15(14), pp. 3206. doi:10.3390/nu15143206 Clinical study
https://doi.org/10.3390/nu15143206 - Jianu, E.M., Pop, R.M., Gherman, L.M., Ranga, F., Levai, A.M., Rus, V., Bolboaca, S.D., Stefan, R.A., Onofrei, M.M., Nati, I.D., Stoia, I.A., Stefan, P.A., Mihu, C. and Mihu, C.M (2024) 'The Effect of Rubus idaeus Polyphenols Extract in Induced Endometriosis in Rats', Molecules, 29(4), pp. 778. doi:10.3390/molecules29040778 Preclinical
https://doi.org/10.3390/molecules29040778 - Cyboran-Mikolajczyk, S., Meczarska, K., Solarska-Sciuk, K., Ratajczak-Wielgomas, K., Oszmianski, J., Jencova, V. and Bonarska-Kujawa, D (2022) 'Protection of Erythrocytes and Microvascular Endothelial Cells against Oxidative Damage by Fragaria vesca L. and Rubus idaeus L. Leaves Extracts - The Mechanism of Action', Molecules, 27(18), pp. 5865. doi:10.3390/molecules27185865 Preclinical
https://doi.org/10.3390/molecules27185865 - Farnaghi, S. and Braniff, K (2022) 'Survey of Raspberry Leaf Tea in pregnancy', Australian and New Zealand Journal of Obstetrics and Gynaecology. doi:10.1111/ajo.13496 Randomized trial
https://doi.org/10.1111/ajo.13496 - Simpson, M., Parsons, M., Greenwood, J. and Wade, K (2001) 'Raspberry leaf in pregnancy: its safety and efficacy in labor', Journal of Midwifery & Women's Health, 46(2), pp. 51--59. doi:10.1016/s1526-9523(01)00095-2 Randomized trial
https://doi.org/10.1016/s1526-9523(01)00095-2
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.