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Omnia Sana · Plant Monograph

Lady’s-mantle

Alchemilla vulgaris

Family RosaceaeParts used Flower, LeafAlso known as Lady's mantle, lion's foot

This monograph compiles 1 documented constituent, 3 pharmacological actions, 6 traditional / indicated uses, supported by 16 cited sources, drawn directly from the Omnia Sana plant database.

Key Constituents

Phenolic compounds and tannins[5, 8]

Lady's mantle is rich in ellagitannins and other tannins (the basis of its astringency) together with phenolic acids (gallic and caffeic acids) and flavonoids such as quercetin and catechin, which underlie its antioxidant activity.

Phenolic compoundsPhenolic acidsTanninsCaffeic acidFlavonoidsQuercetinCatechinsGallic acid

Pharmacological Actions

Anti-inflammatory[4, 6, 7, 9, 14, 15, 16]
Antioxidant[3, 5, 6, 8, 10, 13, 14, 15, 16]
Vulnerary (wound healing)[14, 15, 16]

Traditional & Indicated Uses

Arthritis / joint pain[6, 14, 15, 16]Traditional · 2/10

inferred from anti-inflammatory action

more plants for arthritis / joint pain →detailed sources →
Bruising[14, 15, 16]Traditional · 1/10

inferred from vulnerary action

more plants for bruising →detailed sources →
Inflammation (general)[6, 14, 15, 16]Traditional · 2/10

inferred from anti-inflammatory action

more plants for inflammation (general) →detailed sources →
Menstrual cramps[14, 15, 16]Traditional · 1/10
more plants for menstrual cramps →detailed sources →
Skin irritation[6, 14, 15, 16]Traditional · 2/10

inferred from anti-inflammatory action

more plants for skin irritation →detailed sources →
Wounds[14, 15, 16]Traditional · 1/10

inferred from vulnerary action

more plants for wounds →detailed sources →

Safety, Cautions & Contraindications

Safety note[14, 15, 16]Caution

Generally considered very safe. One of the gentlest astringent herbs in European herbalism. No significant drug interactions. Tannin content means very high doses should be avoided in sensitive stomachs. Not significantly contraindicated in pregnancy at normal herbal tea doses, but medicinal doses should be used cautiously.

Safety note[14, 15, 16]Info

Duke (2002) rates lady's mantle as ++ and notes astringent, angioprotective, anti-inflammatory, and vulnerary activities at the experimental level (score 1). The plant is rich in tannins and is traditionally used for diarrhea, wound healing, and as a mild gynecological tonic. Duke notes its anti-inflammatory and antioxidant properties as experimentally supported. No significant safety concerns are noted at usual herbal doses; the plant is generally well-tolerated (Duke, 2002).

References

REF-0688, REF-0689, REF-2226, REF-2227, REF-0686, REF-0685, REF-2228, REF-0687, REF-2229, REF-2230, REF-2231, REF-2232, REF-2233

References & Sources

  1. Jelaca, S., Jovanovic, I., Bovan, D., Jovanovic, M.Z., Jurisevic, M.M., Dundjerovic, D. and others (2024) 'Dual Role of Alchemilla vulgaris L. Extract in Breast Cancer Regression: Reestablishment of Effective Immune Response', Pharmaceuticals, 17(3). doi:10.3390/ph17030286 Preclinical
    https://doi.org/10.3390/ph17030286
  2. Jelaca, S., Jovanovic, I., Bovan, D., Pavlovic, S., Gajovic, N., Dundjerovic, D. and others (2024) 'Antimelanoma Effects of Alchemilla vulgaris: A Comprehensive In Vitro and In Vivo Study', Diseases, 12(6). doi:10.3390/diseases12060125 Preclinical
    https://doi.org/10.3390/diseases12060125
  3. Kanak, S., Krzeminska, B., Celinski, R., Bakalczuk, M. and Dos Santos Szewczyk, K (2022) 'Phenolic composition and antioxidant activity of Alchemilla species', Plants, 11(20), pp. 2709. doi:10.3390/plants11202709 Meta-analysis / review
    https://doi.org/10.3390/plants11202709
  4. Jakimiuk, K. and Tomczyk, M (2023) 'A review of the traditional uses, phytochemistry, pharmacology, and clinical evidence for the use of the genus Alchemilla (Rosaceae)', Journal of Ethnopharmacology, 320, pp. 117439. doi:10.1016/j.jep.2023.117439 Meta-analysis / review
    https://doi.org/10.1016/j.jep.2023.117439
  5. Jelaca, S., Dajic-Stevanovic, Z., Vukovic, N., Kolasinac, S., Trendafilova, A., Nedialkov, P. and others (2022) 'Beyond Traditional Use of Alchemilla vulgaris: Genoprotective and Antitumor Activity In Vitro', Molecules, 27(23). doi:10.3390/molecules27238113 Traditional / reference
    https://doi.org/10.3390/molecules27238113
  6. Anajirih, N., Abdeen, A., Taher, E.S., Abdelkader, A., Abd-Ellatieff, H.A., Gewaily, M.S. and others (2024) 'Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis', Frontiers in Pharmacology. doi:10.3389/fphar.2024.1394557 Preclinical
    https://doi.org/10.3389/fphar.2024.1394557
  7. Karaoglan, E.S., Bayir, Y., Albayrak, A., Toktay, E., Ozgen, U., Kazaz, C., Kahramanlar, A. and Cadirci, E (2020) 'Isolation of major compounds and gastroprotective activity of Alchemilla on indomethacin induced gastric ulcers in rats', Eurasian Journal of Medicine, 52(3), pp. 249-253. doi:10.5152/eurasianjmed.2020.19243 Preclinical
    https://doi.org/10.5152/eurasianjmed.2020.19243
  8. Vlaisavljevic, S., Jelaca, S., Zengin, G., Mimica-Dukic, N., Berezni, S., Miljic, M. and Dajic Stevanovic, Z (2019) 'Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties', RSC Advances, 9(64), pp. 37474--37483. doi:10.1039/c9ra08231j Preclinical
    https://doi.org/10.1039/c9ra08231j
  9. Kupeli Akkol, E., Demirel, M.A., Bahadir Acikara, O., Suntar, I., Ergene, B., Ilhan, M., Ozbilgin, S., Saltan, G., Keles, H. and Tekin, M (2015) 'Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model', Archives of Gynecology and Obstetrics, 292(3), pp. 619-628. doi:10.1007/s00404-015-3665-6 Preclinical
    https://doi.org/10.1007/s00404-015-3665-6
  10. Dos Santos Szewczyk, K., Pietrzak, W., Klimek, K., Grzywa-Celinska, A., Celinski, R. and Gogacz, M (2022) 'LC-ESI-MS/MS identification of biologically active phenolics in different extracts of Alchemilla acutiloba Opiz', Molecules, 27(3), pp. 621. doi:10.3390/molecules27030621 Preclinical
    https://doi.org/10.3390/molecules27030621
  11. Ozbek, H., Acikara, O.B., Keskin, I., Kirmizi, N.I., Ozbilgin, S., Oz, B.E., Kurtul, E., Ozrenk, B.C., Tekin, M. and Saltan, G (2016) 'Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis', Biomedicine & Pharmacotherapy, 86, pp. 172-176. doi:10.1016/j.biopha.2016.12.005 Preclinical
    https://doi.org/10.1016/j.biopha.2016.12.005
  12. Krivokuca, M., Niketic, M., Milenkovic, M., Golic, N., Masia, C., Scaltrito, M.M., Sisto, F. and Kundakovic, T (2015) 'Anti-Helicobacter pylori activity of four Alchemilla species (Rosaceae)', Natural Product Communications, 10(8), pp. 1369-1371. Preclinical
    Find this source
  13. Duckstein, S.M., Lotter, E.M., Meyer, U., Lindequist, U. and Stintzing, F.C (2013) 'Phenolic constituents from Alchemilla vulgaris L. and Alchemilla mollis (Buser) Rothm. at different dates of harvest', Zeitschrift fur Naturforschung C, 68(1-2), pp. 529-540. Preclinical
    Find this source
  14. Hoffmann, D (2003) 'Medical Herbalism: The Science and Practice of Herbal Medicine'. Traditional / reference
    Find this source
  15. Pauli, A. and Schilcher, H (2012) 'In vitro antimicrobial activities of essential oils monographed in the European Pharmacopoeia 6th edition'. Traditional / reference
    Find this source
  16. Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
    https://powo.science.kew.org

Record last updated 2026-06-20 · Provenance: book+pubmed · Status: verified

This fact sheet is generated automatically from the Omnia Sana plant database and reflects its latest synced data. It is provided for educational purposes only and is not medical advice. Always consult a qualified practitioner before using medicinal plants.

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