Plant Comparison

Ground Elder vs Willow Bark

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant

Second plant

Plant AGround ElderAegopodium podagrariaApiaceaeFull monograph →

Plant BWillow BarkSalix albaSalicaceaeFull monograph →

At a glance

Ground Elder and Willow Bark: they share 6 indicated uses (arthritis / joint pain, back pain, headache, …); 2 pharmacological actions in common.

Ground ElderWillow Bark

Constituents32

Pharmacological actions43

Indicated uses97

Safety notes22

Cited sources1913

Indicated uses

Only Ground Elder

Swelling / fluid retentionUrinary supportUrinary tract infection (UTI)

Shared (6)

Arthritis / joint painBack painHeadacheInflammation (general)Pain (general)Skin irritation

Only Willow Bark

Fever

Pharmacological actions

Only Ground Elder

Anti-rheumatic / anti-arthriticDiuretic

Shared (2)

Analgesic (pain relief)Anti-inflammatory

Only Willow Bark

Antipyretic (reduces fever)

Evidence face-off — shared uses

Condition	Ground Elder	Willow Bark	Verdict
Arthritis / joint pain	1/10	7/10	Stronger for Willow Bark
Back pain	1/10	9/10	Stronger for Willow Bark
Headache	1/10	1/10	Comparable evidence
Inflammation (general)	1/10	8/10	Stronger for Willow Bark
Pain (general)	1/10	9/10	Stronger for Willow Bark
Skin irritation	1/10	8/10	Stronger for Willow Bark

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Polyacetylenes (falcarindiol)^{[6, 10]}

Falcarindiol, a potent COX-1 inhibitor (IC50 0.3 microM), identified as a key anti-inflammatory constituent underlying the plant's traditional anti-rheumatic and analgesic use.

Flavonoids and phenolic compounds^[1]

Contribute to the plant's antioxidant activity.

FlavonoidsPhenolic compounds

Coumarins and essential oil^[1]

Minor aromatic and coumarin constituents of the aerial parts.

CoumarinsEssential (volatile) oil

Salicin and related salicylates^{[1, 2, 6, 7, 11, 12]}

Metabolised in the body to salicylic acid - the 'natural aspirin' that gives the analgesic, anti-inflammatory and antipyretic effects.

Salicin

Polyphenols, flavonoids and tannins^{[10, 12]}

Contribute additionally to the anti-inflammatory and antioxidant activity.

Phenolic compoundsFlavonoidsTannins

Pharmacological Actions

Analgesic (pain relief)^{[11, 12, 13]}

Anti-inflammatory^{[1, 3, 6, 10, 11, 12, 13]}

Anti-rheumatic / anti-arthritic^{[1, 11, 12, 13]}

Diuretic^{[1, 11, 12, 13]}

Analgesic (pain relief)^{[1, 8, 9, 11, 12, 13]}

Analgesic and anti-inflammatory for low back pain (moderate evidence; dose-dependent, around 240 mg salicin/day) - in an RCT, 240 mg salicin/day left 39% pain-free vs 6% on placebo within 4 weeks

Anti-inflammatory^{[1, 4, 11, 12, 13]}

Analgesic and anti-inflammatory for low back pain (moderate evidence; dose-dependent, around 240 mg salicin/day) - in an RCT, 240 mg salicin/day left 39% pain-free vs 6% on placebo within 4 weeks

Antipyretic (reduces fever)^[12]

Antipyretic (reduces fever)

Traditional & Indicated Uses

Arthritis / joint pain^{[11, 12, 13]}Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1

Label: Arthritis / joint pain

Back pain^{[11, 12, 13]}Traditional · 1/10

inferred from anti-rheumatic action

Evidence: 1

Label: Back pain

Headache^{[11, 12, 13]}Traditional · 1/10

inferred from analgesic action

Evidence: 1

Label: Headache

Inflammation (general)^{[11, 12, 13]}Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1

Label: Inflammation (general)

Pain (general)^{[11, 12, 13]}Traditional · 1/10

Evidence: 1

Label: Pain (general)

Skin irritation^{[11, 12, 13]}Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1

Label: Skin irritation

Swelling / fluid retention^{[11, 12, 13]}Traditional · 1/10

inferred from diuretic action

Evidence: 1

Label: Swelling / fluid retention

Urinary support^{[11, 12, 13]}Traditional · 1/10

inferred from diuretic action

Evidence: 1

Label: Urinary support

Urinary tract infection (UTI)^{[11, 12, 13]}Traditional · 1/10

inferred from diuretic action

Evidence: 1

Label: Urinary tract infection (UTI)

Arthritis / joint pain^{[11, 12]}Good · 7/10

Relief of joint pain, osteoarthritis and rheumatic complaints

Evidence: 7

Label: Arthritis / joint pain

Back pain^{[8, 9, 11, 12, 13]}Strong · 9/10

Analgesic and anti-inflammatory for low back pain (moderate evidence; dose-dependent, around 240 mg salicin/day) - in an RCT, 240 mg salicin/day left 39% pain-free vs 6% on placebo within 4 weeks

Evidence: 9

Label: Back pain

Fever^[12]Traditional · 1/10

Antipyretic (reduces fever)

Evidence: 1

Label: Fever

Headache^[12]Traditional · 1/10

Evidence: 1

Label: Headache

Inflammation (general)^{[11, 12, 13]}Good · 8/10

inferred from anti-inflammatory action

Evidence: 8

Label: Inflammation (general)

Pain (general)^{[8, 11, 12, 13]}Strong · 9/10

Analgesic and anti-inflammatory for low back pain (moderate evidence; dose-dependent, around 240 mg salicin/day) - in an RCT, 240 mg salicin/day left 39% pain-free vs 6% on placebo within 4 weeks; Relief of joint pain, osteoarthritis and rheumatic complaints

Evidence: 9

Label: Pain (general)

Skin irritation^{[11, 12, 13]}Good · 8/10

inferred from anti-inflammatory action

Evidence: 8

Label: Skin irritation

Safety, Cautions & Contraindications

Safety note^{[9, 11, 12, 13]}Caution

Generally safe as a food plant when young leaves are harvested. Contains furocoumarins (photosensitising compounds) — handling large quantities in bright sunlight may cause skin irritation. Individuals with Apiaceae allergies should exercise caution. Not recommended in therapeutic doses during pregnancy.

Safety note^{[11, 12, 13, 14]}Info

Duke (2002) does not appear to include a dedicated entry for ground elder (Aegopodium podagraria) in the Handbook of Medicinal Herbs, Second Edition.

Safety note^[12]Caution

Because it works like aspirin, avoid willow bark if you are allergic to aspirin or salicylates, and do NOT give it to children or teenagers with a viral illness (risk of Reye's syndrome). Use caution in asthma (salicylate sensitivity).

Safety note^[12]Caution

Avoid with anticoagulant/antiplatelet medicines (bleeding risk) and in active peptic ulcer; avoid in pregnancy (especially the third trimester) and breastfeeding.

External Ids

Gbif: 3034620

Wikidata: Q217778

Wikidata: Q156918

Botanical Description

Vigorous, low, patch-forming perennial herb spreading rapidly by white, brittle, creeping rhizomes. The leaves are broad and twice-ternate (in threes of threes), with oval, sharply toothed leaflets, borne on long stalks. In summer it sends up hollow, grooved, unspotted green stems topped with flat umbels of small white flowers, typical of the carrot family. The whole plant smells mildly of parsley or carrot when crushed.^[1]

Height: 30-100 cm

Habit: Low, mat-forming, rhizomatous perennial herb

Leaves: Broad, twice-ternate, with oval sharply toothed leaflets in groups of three

Flowers: Small white flowers in flat compound umbels

Stem: Hollow, grooved, plain green (never purple-spotted)

Root: Thin, white, brittle, fast-spreading creeping rhizome

Fruit: Small ridged schizocarp typical of the carrot family

Flowering Period: May-July

Large deciduous tree (Salicaceae), 10-25 m tall (occasionally taller), fast-growing with a broad crown. Leaves are narrow and lance-shaped, silvery-white and silky-hairy beneath, giving the tree a shimmering appearance in the wind. Tiny flowers are borne in catkins appearing with the leaves in spring; the species is dioecious. The fruit is a small capsule releasing cottony-tufted seeds.^[12]

Height: 10-25 m

Habit: Large, fast-growing deciduous tree, dioecious

Leaves: Narrow, lance-shaped, silvery-white and silky-hairy beneath

Flowers: Tiny, in catkins with the leaves

Stem: Broad-crowned trunk

Root: Extensive, water-seeking root system

Fruit: Small capsule with cottony-tufted seeds

Flowering Period: April-May

Habitat

A common weed of gardens, hedgerows, shaded waste ground and disturbed soil, often near old dwellings; native to Europe and temperate Asia and widely naturalised elsewhere, where its invasive spreading rhizomes make it a persistent garden weed.^[1]

Native to Europe, western and central Asia and North Africa, growing on damp ground along riverbanks, floodplains and wet meadows; widely planted and naturalised elsewhere.^[12]

Harvesting

The young leaves and stems are gathered in spring, before flowering, when they are most tender and least bitter; the root can be dug at the same time. Careful identification against poisonous Apiaceae look-alikes (poison hemlock, hemlock water-dropwort, fool's parsley) is essential before harvesting.^[1]

Parts: Leaf, Root, Stem

Season: Spring, before flowering

Bark is stripped from young branches (2-3-year-old growth is preferred, as salicin content is highest in younger bark) in spring, when the rising sap makes the bark peel most easily, then dried.^[12]

Parts: Bark

Season: Spring

Traditional Uses

Ground elder has long been used in European folk medicine as a remedy for gout and rheumatic and arthritic joint pain (reflected in the name 'podagraria', from podagra, gout), typically applied as a poultice or taken as a decoction. The young leaves have also been eaten as a spring pot-herb, valued for their nutrient content as well as their medicinal reputation.^[1]

Willow bark has one of the longest documented histories of any medicinal plant, used since antiquity (recorded by Hippocrates) as a remedy for pain and fever. Its salicin content, chemically related to aspirin, gives it official European herbal-monograph recognition for mild joint pain, headache and feverish colds, with modern clinical trials supporting benefit for low back pain.^{[11, 12]}

Preparations

Decoction^[1]

Dried or fresh leaf, stem and root simmered in water as a traditional remedy for gout and rheumatic pain.

Poultice^[1]

Fresh leaves crushed or boiled and applied directly to gouty or arthritic joints.

Fresh leaf (culinary/medicinal)^[1]

Young spring leaves eaten as a cooked pot-herb, similarly to spinach, continuing the traditional food-medicine use.

Decoction^[12]

Dried bark simmered in water - the traditional preparation, since salicin needs proper simmering (not just a quick infusion) to extract well.

Standardised extract (capsule/tablet)^[11]

Standardised to salicin content, the form used in clinical trials.

References

REF-0719, REF-0720, REF-0721, REF-1688, REF-1689, REF-1690, REF-1691, REF-2560, REF-2561, REF-2562

REF-1253, REF-1254, REF-1255, REF-1256, REF-1257, REF-1258, REF-1259, REF-1260, REF-1261, REF-1262

Lookalikes Review

Outcome: has-lookalikes

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-06

Outcome: none-known

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-07

Dangerous Lookalikes

Safety note^{[15, 16]}Fatal

Dangerous Plant: conium-maculatum

Confused Part: Young leaves and foliage gathered in spring, before flowering.

Confusion Context: Poison hemlock is a carrot-family plant with lacy foliage that can be mistaken for edible umbellifer greens; its alkaloid coniine causes an ascending paralysis that stops breathing, and even a small amount can be fatal. It grows in the same disturbed ground, hedgerows and waste places as ground elder.

Distinguishing Features: Ground elder leaves are in neat groups of three (twice-ternate) with broad, oval, sharply toothed leaflets. Poison hemlock leaves are finely divided, feathery and fern-like — not in groups of three., Poison hemlock has a hairless stem blotched and streaked with purple; ground elder's stem is plain green and grooved, never purple-spotted., Crushed ground elder smells mildly of parsley or carrot; crushed poison hemlock smells foul and musty ('mousy').

Key Test: Check the stem: purple blotches or streaks on a smooth, hairless stem = poison hemlock — do not eat. Ground elder has a plain green grooved stem, broad toothed leaflets in threes, and a mild parsley smell (never mousy).

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-06

Safety note^[17]Fatal

Dangerous Plant: oenanthe-crocata

Confused Part: Foliage (mistaken for celery or parsley) and roots (mistaken for parsnip), where the plant grows near water.

Confusion Context: Hemlock water-dropwort is probably the most poisonous plant in Britain; its toxin oenanthotoxin causes violent convulsions, and its parsnip-like roots and celery-like leaves have repeatedly been eaten by mistake, often fatally. It grows in and beside water.

Distinguishing Features: Habitat is the first filter: hemlock water-dropwort grows in or right beside water (wet ditches, streams, marshes); ground elder grows in dry gardens, hedgerows and disturbed ground., Hemlock water-dropwort has a cluster of pale, swollen, finger-like root tubers ('dead man's fingers'); ground elder spreads by thin white creeping rhizomes, not fleshy tubers.

Key Test: If the plant is growing in or at the edge of water and has a cluster of swollen finger-like root tubers, treat it as hemlock water-dropwort — do not touch the roots. Ground elder grows in dry ground from thin creeping rhizomes.

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-06

Safety note^{[18, 19]}Dangerous

Dangerous Plant: aethusa-cynapium

Confused Part: Young leaves and foliage in spring.

Confusion Context: Fool's parsley is a common carrot-family weed of gardens and disturbed ground — named for being mistaken for parsley — that contains toxic polyacetylenes and can cause burning of the mouth, vomiting and neurological effects, especially in children.

Distinguishing Features: Fool's parsley leaves are finely dissected, thin, dark green and fern-like; ground elder leaves are broad, oval, toothed leaflets in neat groups of three — a coarser, very different leaf., In flower, fool's parsley shows three long, narrow bracteoles hanging down beneath each small flower cluster (a 'beard'); ground elder umbels have no such drooping beard., Crushed fool's parsley smells foul and acrid ('mousy'); ground elder smells mildly of parsley or carrot.

Key Test: Finely dissected fern-like leaves with a foul mousy smell — and, if flowering, a drooping three-part 'beard' under each little umbel — mean fool's parsley, not ground elder (which has broad toothed leaflets in threes and a mild parsley scent).

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-06

Not documented

Dosage

Not documented

Standardised extract^{[11, 12]}

Clinical trials for back pain have used around 240 mg salicin/day of standardised extract. Educational reference only, not a prescription; avoid if allergic to aspirin/salicylates, in children/teenagers with a viral illness (Reye's syndrome risk), or alongside anticoagulants.

References & Sources

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https://doi.org/10.3390/molecules30071603
Engelhardt, L., Pöhnl, T. and Neugart, S (2022) 'Edible Wild Vegetables Urtica dioica L. and Aegopodium podagraria L.: Antioxidants Affected by Processing', Plants (Basel), 11(20), pp. 2710. doi:10.3390/plants11202710 Preclinical
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Jakubczyk, K., Łukomska, A., Czaplicki, S., Wajs-Bonikowska, A., Gutowska, I. et al (2021) 'Bioactive Compounds in Aegopodium podagraria Leaf Extracts and Their Effects against Fluoride-Modulated Oxidative Stress in the THP-1 Cell Line', Pharmaceuticals (Basel), 14(12), pp. 1334. doi:10.3390/ph14121334 Preclinical
https://doi.org/10.3390/ph14121334
Tovchiga, O.V (2016) 'The influence of goutweed (Aegopodium podagraria L.) tincture and metformin on the carbohydrate and lipid metabolism in dexamethasone-treated rats', BMC Complementary and Alternative Medicine, 16, pp. 235. doi:10.1186/s12906-016-1221-y Preclinical
https://doi.org/10.1186/s12906-016-1221-y
Flieger, J. and Flieger, M (2020) 'The [DPPH/DPPH-H]-HPLC-DAD Method on Tracking the Antioxidant Activity of Pure Antioxidants and Goutweed (Aegopodium podagraria L.) Hydroalcoholic Extracts', Molecules, 25(24), pp. 6005. doi:10.3390/molecules25246005 Preclinical
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Prior, R.M., Lundgaard, N.H., Light, M.E., Stafford, G.I., van Staden, J. and Jager, A.K (2007) 'The polyacetylene falcarindiol with COX-1 activity isolated from Aegopodium podagraria L', Journal of Ethnopharmacology, 113(1), pp. 176-178. doi:10.1016/j.jep.2007.05.005 Preclinical
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Niziol-Lukaszewska, Z., Zagorska-Dziok, M., Ziemlewska, A. and Bujak, T (2020) 'Comparison of the Antiaging and Protective Properties of Plants from the Apiaceae Family', Oxidative Medicine and Cellular Longevity, 2020, pp. 5307614. doi:10.1155/2020/5307614 Preclinical
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Baranauskiene, R., Rackauskiene, I. and Venskutonis, P.R (2025) 'Characterization of Steam Volatiles and Evaluation of the Antioxidant Properties of Different Extracts from Leaves and Roots of Aegopodium podagraria L', Molecules, 30(24), pp. 4786. doi:10.3390/molecules30244786 Preclinical
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Ojala, T., Vuorela, P., Kiviranta, J., Vuorela, H. and Hiltunen, R (1999) 'A bioassay using Artemia salina for detecting phototoxicity of plant coumarins', Planta Medica, 65(8), pp. 715-718. doi:10.1055/s-1999-14049 Preclinical
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Schulte, K.E. and Wulfhorst, G (1977) 'Polyacetylene compounds from Aegopodium podagraria L', Archiv der Pharmazie, 310(4), pp. 285-298. doi:10.1002/ardp.19773100403 Preclinical
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Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
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Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
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Dayan, A.D (2024) 'Death of Socrates: a likely case of poison hemlock (Conium maculatum) poisoning', Clinical Toxicology (Philadelphia, Pa.), 62(1), pp. 56-60. doi:10.1080/15563650.2024.2309328 Clinical study
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King County Noxious Weeds (2024) 'Poison hemlock (Conium maculatum) identification and control'. Available at: https://kingcounty.gov/en/dept/dnrp/nature-recreation/environment-ecology-conservation/noxious-weeds/identification-control/poison-hemlock Traditional / reference
https://kingcounty.gov/en/dept/dnrp/nature-recreation/environment-ecology-conservation/noxious-weeds/identification-control/poison-hemlock
Mitchell, M.I. and Routledge, P.A (1978) 'Hemlock water dropwort poisoning - a review', Clinical Toxicology, 12(4), pp. 417-26. doi:10.3109/15563657809150012 Clinical study
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Teuscher, E. and Greger, H. and Adrian, V (1990) 'Toxicity of Aethusa cynapium L. (fool's parsley)', Pharmazie, 45(7), pp. 537-8. Available at: https://pubmed.ncbi.nlm.nih.gov/2236201/ Preclinical
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Minnesota Wildflowers (2024) 'Aethusa cynapium (Fool's Parsley)'. Available at: https://www.minnesotawildflowers.info/flower/fools-parsley Traditional / reference
https://www.minnesotawildflowers.info/flower/fools-parsley

Shara, M. and Stohs, S.J (2015) 'Efficacy and Safety of White Willow Bark (Salix alba) Extracts', Phytotherapy Research, 29(8), pp. 1112-1116. doi:10.1002/ptr.5377 Meta-analysis / review
https://doi.org/10.1002/ptr.5377
Maistro, E.L., Terrazzas, P.M., Perazzo, F.F., Gaivao, I.O.M. and others (2020) 'Salix alba (white willow) medicinal plant presents genotoxic effects in human cultured leukocytes', Journal of Toxicology and Environmental Health, Part A, 82(23-24), pp. 1223-1234. doi:10.1080/15287394.2019.1711476 Preclinical
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Phillips, H.N., Sharpe, K.T., Endres, M.I. and Heins, B.J (2021) 'Effects of oral white willow bark (Salix alba) and intravenous flunixin meglumine on prostaglandin E2 in healthy dairy calves', JDS Communications, 3(1), pp. 49-54. doi:10.3168/jdsc.2021-0138 Preclinical
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Kong, C.S., Kim, K.H., Choi, J.S., Kim, J.E. and others (2014) 'Salicin, an extract from white willow bark, inhibits angiogenesis by blocking the ROS-ERK pathways', Phytotherapy Research, 28(8), pp. 1246-1251. doi:10.1002/ptr.5126 Preclinical
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Noleto-Dias, C., Ward, J.L., Bellisai, A., Lomax, C. and Beale, M.H (2018) 'Salicin-7-sulfate: A new salicinoid from willow and implications for herbal medicine', Fitoterapia, 127, pp. 166-172. doi:10.1016/j.fitote.2018.02.009 Preclinical
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Wolfle, U., Haarhaus, B., Kersten, A., Fiebich, B. and others (2015) 'Salicin from Willow Bark can Modulate Neurite Outgrowth in Human Neuroblastoma SH-SY5Y Cells', Phytotherapy Research, 29(10), pp. 1494-1500. doi:10.1002/ptr.5400 Preclinical
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Amel Zabihi, N., Mahmoudabady, M., Soukhtanloo, M., Hayatdavoudi, P. and others (2018) 'Salix alba attenuated oxidative stress in the heart and kidney of hypercholesterolemic rabbits', Avicenna Journal of Phytomedicine, 8(1), pp. 63-72. Preclinical
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https://www.ema.europa.eu/en/medicines/herbal/salicis-cortex
Chrubasik, S., Eisenberg, E., Balan, E., Weinberger, T., Luzzati, R. and Conradt, C (2000) 'Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study', The American Journal of Medicine, 109(1), pp. 9--14. doi:10.1016/S0002-9343(00)00442-3 Randomized trial
https://doi.org/10.1016/S0002-9343(00)00442-3

Ground Elder monograph Willow Bark monograph Compare other plants

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.