Peach-leaved bellflower (Campanula persicifolia) as a tool for helping with Skin irritation

The Campanula genus (Campanulaceae) comprises nearly 300 herbaceous species widely distributed across the Northern Hemisphere. Beyond their ornamental value, many species have been traditionally employed to treat inflammatory, respiratory, and cardiovascular disorders. Phytochemical studies have revealed a remarkable diversity of bioactive constituents, including phenolic acids, flavonoids, coumarins, acetylenic compounds, triterpenes, and alkaloids. These metabolites exhibit broad pharmacological activities, such as antioxidant, anti-inflammatory, antimicrobial, cytotoxic, and cardioprotective effects. This review provides a comprehensive overview of the isolated compounds from the Campanula species, summarizing their chemical diversity, pharmacological mechanisms, and structure-activity relationships. It also highlights underexplored species and compound classes with potential therapeutic significance. By integrating the phytochemical evidence with pharmacological insights, this work underscores the value of the Campanula species as promising natural resources for future drug discovery and development.

Plants are valuable sources of bioactive metabolites that influence cellular physiology and tissue repair. This study investigates the phytochemical composition and cellular wound-healing potential of the aqueous extract of Campanula macrostachya Boiss. (Campanulaceae), an endemic Anatolian species traditionally used for treating skin injuries. The extract was obtained via ultrasound-assisted extraction and characterized by LC–MS, revealing chlorogenic and caffeic acids as the dominant phenolics. Antioxidant properties were evaluated using DPPH, ABTS, FRAP, CUPRAC, phosphomolybdenum, and ferrous ion chelating assays, while enzyme inhibition screening included acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-amylase, and α-glucosidase inhibitory activities. In human dermal fibroblast (HDFa) cultures, the extract exhibited no cytotoxicity up to 62.5 µg/mL, significantly enhanced cell viability, and promoted 98% wound closure within 48 h in scratch assays. Moreover, TNF-α and IL-1β levels were downregulated, suggesting an anti-inflammatory contribution to tissue repair. These findings provide mechanistic insights into the cellular basis of C. macrostachya’s ethnopharmacological use and support its potential as a source of phenolic compounds that modulate redox balance and cytokine activity. The study highlights the relevance of plant-derived antioxidants in regulating fibroblast behavior and suggests their potential for future development of natural agents for skin-related applications, based on in vitro findings.