Symptom → Plant Sources
Artichoke (Cynara scolymus) as a tool for helping with Liver support
Hepatoprotective / liver support (protects liver cells and may aid their regeneration)
Artichoke (Cynara scolymus) leaf extract was one of the few herbal remedies which the clinical and experimental trials have complemented each other. Both experimental and clinical effects have been verified through extensive biomedical herbal remedy research. Specifically, antioxidant, choleretic, hepatoprotective, bile-enhancing and lipid-lowering effects have been demonstrated, which corresponded with its historical use. Ongoing research seems to indicate that artichoke indeed have medicinal qualities. Most significant appears to be its beneficial effect on the liver. In animal studies, liquid extracts of the roots and leaves of artichoke have demonstrated an ability to protect the liver, with possibly even to help liver cells regenerate. Although research is not yet conclusive, scientists were optimistic that its long-standing use in humans for digestive and bowel problems was indeed justified. It may also play a role in lowering cholesterol and thus help to prevent heart disease. Boiled wild artichoke reduced postprandial glycemic and insulinemic responses in normal subjects but has no effect on metabolic syndrome patients. This article intended to review the wide ranging pharmacological effects of artichoke leaf extract.
1 source supporting Artichoke for Liver support. Includes scientific publications, books, monographs and traditional-use references.
Mechanistic basis
This use is associated with the plant's choleretic / cholagogue (bile flow), hepatoprotective (liver support) actions. Further evidence for that pharmacology:
This review describes the anti-inflammatory, antioxidant, liver-protective, bile-expelling, antimicrobial and lipid-lowering properties of globe artichoke (Cynara scolymus), attributing its health benefits largely to its polyphenol content and supporting use in cardiovascular, metabolic and digestive disorders.
This systematic review and meta-analysis of animal studies provided convincing evidence for the antioxidant activity of artichoke (Cynara scolymus), which increased hepatic superoxide dismutase, catalase and glutathione and decreased malondialdehyde, supporting its hepatoprotective use.
Artichoke (Cynara scolymus) leaf extract protected rat liver against diazinon-induced injury, reducing serum liver enzymes, malondialdehyde, TNF-alpha and hepatic TNF-alpha gene expression while improving antioxidant enzyme activity and histopathology, confirming its hepatoprotective action.