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Common yellow woodsorrel (Oxalis stricta) as a tool for helping with Infection (general)
inferred from antimicrobial/antiparasitic action
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Antibacterial activity of ethanolic and aqueous extracts of two medicinal plants including Oxalis corniculata (EtOc, AqOc) and Artemisia annua (EtAa, AqAa) as well as A. annua essential oil (EoAa) was investigated on multi-drug resistance (MDR) E. coli . Microdilution and agar well diffusion methods were used to determine the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) as well as the inhibition zone. The phytconstituents of these products were analyzed using Reverse-phase High- performance liquid chromatography (RP-HPLC) and gas chromatography-mass spectrometry (GC-mass). The order of bacteriostatic and bacteriocide rate of the products can be shown as follows: EoAa>AqOc>EtAa = AqAa>EtOc, but the bactericidal effect of A. annua extracts is higher than of O. corniculata based on the MIC/MBC ratio and the order is as follows: EoAa>EtAa = AqAa>EtOc>AqOc. The most potent product, i.e. EoAa with a 56.7% inhibition of all isolates, has the potential to substitute 13 used antibiotics including oxacillin, amoxicillin, ampicillin, amoxicillin-clavulanic acid, tetracycline, streptomycin, ciprofloxacin, ceftriaxone, cefazolin, cefuroxime, cefotaxime, ceftazidime and cefixime ( P ). Different terpenoids were detected and measured in EoAa and catechin flavonoids in extracts of both plants, quercetin in extracts of O. corniculata but it was only possible to detect chlorogenic acid polyphenol in AqAa. Due to the antibacterial activities of the studied products, more effective than some antibiotics and their edible consumption, these products can be suggested as an alternative to some antibiotics and food preservatives to fight against MDR E. coli.
Oxalis corniculata is a naturally occurring weed that has been used in traditional medicine for the cure of dysentery and diarrhea in India. One of the common causes of dysentery is due to infection by the protist pathogen Entamoeba histolytica. Bioactivity profiling of extracts from O. corniculata identified several compounds that showed antiamoebic activity in axenic cultures of E. histolytica. These were characterized by nuclear magnetic resonance, infrared, and mass spectrometry as (i) Oc-1, a mixture of saturated fatty acids C₂₄ to C₂₈; (ii) Oc-2, a mixture of long-chain alcohols C₁₈ to C₂₈; and (iii) Oc-3, a single compound that was a galacto-glycerolipid (GGL). Of the different compounds that were obtained, the strongest antiamoebic activity was found in GGL. The addition of GGL to E. histolytica xenic cultures containing other microbial flora from the large intestine did not affect its antiamoebic activity. Amoebicidal concentrations of GGL had no effect on intestinal microbial flora or on the mammalian cell line HEK-293. GGL was also found to be equally effective in killing another protist pathogen, Giardia lamblia, that causes diarrhea in humans. The importance of this study is based on the identification of novel natural products and the possibility of developing these compounds as active agents to treat at least two pathogenic parasitic intestinal infections endemic to tropical regions.
2 sources supporting Common yellow woodsorrel for Infection (general). Includes scientific publications, books, monographs and traditional-use references.
Mechanistic basis
This use is associated with the plant's antimicrobial action. Further evidence for that pharmacology:
Purpose To analyze phytochemical composition, antioxidant potential, antimicrobial activity and α-glucosidase, cholinesterase and Monoamine oxidase inhibitory potential of Oxalis corniculata extract. Methods Phytochemicals of the 70% ethanolic extract of O. corniculata were quantitatively determined by standard spectrophotometric method. The anti-oxidative and antibacterial potential were investigated by DPPH scavenging test and by well-diffusion method respectively. The p-NPG technique was applied to evaluate α-glucosidase inhibition potential. Moreover, cholinesterase and Monoamine oxidase -A & -B activities were examined by Elman's method and fluorometric kynuramine deamination test respectively. Results Phytochemical study revealed the presence of tannin quantity in range 586 ± 0.05 µg/mg followed by flavonoid; 154.83 ± 0.04 µg/mg and phenolic contents; 135.29 ± 0.01 µg/mg. DPPH radical scavenging of the extract indicates good IC50 value 40.74 µg/ml according to the standard ascorbic acid; 25.79 µg/ml. The bacterial inhibition revealed that the extract were high inhibitory against E. coli, H. influenza and k. pneumonia while showing no inhibition against Acetobactor aceti. Similarly, Acetylcholinesterase and Butyrylcholinesterase inhibition result revealed that O. corniculata have effective anti-cholinesterase potential with the IC50 value of Acetylcholinesterase; 34.54 µg/ml and Butyrylcholinesterase; 8.91 µg/ml. Moreover, O. corniculata has good potential against MAO-B inhibition with an IC50 value; 60.68 µg/ml, while showing IC50 value; 274.23 µg/ml against MAO-A. Furthermore, the inhibitory potential against α- glucosidase of the extract shows significant IC50 value (40.59 µg/ml). Conclusion O. corniculata exhibits potential as a valuable reservoir of natural bioactive compounds endowed with a wide array of health-promoting properties.