Omnia Sana · Plant Monograph
Horehound
Marrubium vulgare
This monograph compiles 3 documented constituents, 4 pharmacological actions, 9 traditional / indicated uses, supported by 13 cited sources, drawn directly from the Omnia Sana plant database.
Key Constituents
The characteristic bitter principle (pharmacopoeial material contains at least 0.7%); drives the expectorant and digestive actions. A phytochemical/pharmacological overview identifies marrubiin and the phenolic fraction as the basis for antioxidant, anti-inflammatory and antimicrobial activity.
Antioxidant and anti-inflammatory constituents.
Astringent and aromatic constituents of the herb.
Pharmacological Actions
Traditional & Indicated Uses
Bitter digestive for dyspeptic complaints (indigestion, bloating, flatulence) and loss of appetite
more plants for loss of appetite →detailed sources →Bitter digestive for dyspeptic complaints (indigestion, bloating, flatulence) and loss of appetite
more plants for bloating →detailed sources →Expectorant for productive cough and catarrh of the upper respiratory tract / bronchitis
more plants for bronchitis →detailed sources →Antispasmodic (traditional use in whooping cough); Expectorant for productive cough and catarrh of the upper respiratory tract / bronchitis
more plants for cough →detailed sources →Bitter digestive for dyspeptic complaints (indigestion, bloating, flatulence) and loss of appetite
more plants for indigestion →detailed sources →inferred from antispasmodic action
more plants for menstrual cramps →detailed sources →inferred from antispasmodic action
more plants for muscle spasm →detailed sources →inferred from expectorant action
more plants for respiratory support →detailed sources →Soothes sore throat (traditional)
more plants for sore throat →detailed sources →Safety, Cautions & Contraindications
As a strong bitter it may aggravate hyperacidity; theoretical caution in peptic ulcer. Large amounts have shown effects on heart rhythm and blood pressure in studies, so avoid excessive intake.
Traditional use only; a cough or digestive complaint that persists needs medical assessment. Use in pregnancy and breastfeeding is not recommended.
References
REF-0920, REF-0921, REF-0922, REF-0923, REF-0924, REF-0925, REF-0926, REF-0927, REF-0928, REF-0929References & Sources
- Lazarova, M.I., Tsvetanova, E.R., Georgieva, A.P., Stefanova, M.O. and others (2024) 'Marrubium vulgare Extract Improves Spatial Working Memory and Oxidative Stress Damage in Scopolamine-Treated Rats', Journal of Alzheimer's Disease, 99(s1), pp. S157-S169. doi:10.3233/JAD-231011 Preclinical
https://doi.org/10.3233/JAD-231011 - Rodriguez Villanueva, J. and Martin Esteban, J (2016) 'An Insight into a Blockbuster Phytomedicine; Marrubium vulgare L. Herb. More of a Myth than a Reality?', Phytotherapy Research, 30(10), pp. 1551-1558. doi:10.1002/ptr.5661 Traditional / reference
https://doi.org/10.1002/ptr.5661 - Acimovic, M., Ivanovic, S., Simic, K., Pezo, L. and others (2021) 'Chemical Characterization of Marrubium vulgare Volatiles from Serbia', Plants (Basel), 10(3), pp. 600. doi:10.3390/plants10030600 Preclinical
https://doi.org/10.3390/plants10030600 - Amri, B., Martino, E., Vitulo, F., Corana, F. and others (2017) 'Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties', Molecules, 22(11), pp. 1851. doi:10.3390/molecules22111851 Preclinical
https://doi.org/10.3390/molecules22111851 - Lazarova, M., Stefanova, M., Denev, P., Taseva, T. and others (2024) 'Neuroprotective Effect of Marrubium vulgare Extract in Scopolamine-Induced Cognitive Impairment in Rats: Behavioral and Biochemical Approaches', Biology (Basel), 13(6), pp. 426. doi:10.3390/biology13060426 Preclinical
https://doi.org/10.3390/biology13060426 - Aitbaba, A., Kabdy, H., Baslam, A., Azraida, H. and others (2024) 'Chemical Investigation and Antinociceptive Activity Evaluation of Marrubium vulgare L. Aqueous Extract', Chemistry & Biodiversity, 21(5), pp. e202400228. doi:10.1002/cbdv.202400228 Preclinical
https://doi.org/10.1002/cbdv.202400228 - Abidi, A., Dhaouafi, J., Brinsi, C., Tounsi, H. and Sebai, H (2022) 'Tunisian Horehound (Marrubium vulgare) Aqueous Extract Improves Treatment of Bleomycin-Induced Lung Fibrosis in Rat', Dose-Response, 20(3), pp. 15593258221119300. doi:10.1177/15593258221119300 Preclinical
https://doi.org/10.1177/15593258221119300 - Rezgui, M., Basma, M., Neng, N., Nogueira, J.M. and others (2021) 'Evaluation of Marrubium vulgare Growing Wild in Tunisia for Its Potential as a Dietary Supplement', Foods, 10(11), pp. 2864. doi:10.3390/foods10112864 Preclinical
https://doi.org/10.3390/foods10112864 - Gourich, A.A., Touijer, H., Drioiche, A., Asbabou, A. and others (2023) 'Insight into biological activities of chemically characterized extract from Marrubium vulgare L. in vitro, in vivo and in silico approaches', Frontiers in Chemistry, 11, pp. 1238346. doi:10.3389/fchem.2023.1238346 Preclinical
https://doi.org/10.3389/fchem.2023.1238346 - Yousefi, K., Hamedeyazdan, S., Torbati, M. and Fathiazad, F (2016) 'Chromatographic Fingerprint Analysis of Marrubiin in Marrubium vulgare L. via HPTLC Technique', Advanced Pharmaceutical Bulletin, 6(1), pp. 131-136. doi:10.15171/apb.2016.019 Preclinical
https://doi.org/10.15171/apb.2016.019 - European Medicines Agency (HMPC) (2013) 'European Union herbal monograph on Marrubium vulgare L., herba (Marrubii herba)'. Available at: https://www.ema.europa.eu/en/medicines/herbal/marrubii-herba Traditional / reference
https://www.ema.europa.eu/en/medicines/herbal/marrubii-herba - ESCOP (European Scientific Cooperative on Phytotherapy) (n.d.) 'Marrubii herba (White Horehound) monograph', pp. com. Available at: https://www.escop.com/downloads/white-horehound/ Traditional / reference
https://www.escop.com/downloads/white-horehound/ - Acimovic, M., Jeremic, K., Salaj, N., Gavaric, N., Kiprovski, B., Sikora, V. and Zeremski, T (2020) 'Marrubium vulgare L.: A Phytochemical and Pharmacological Overview', Molecules, 25(12). doi:10.3390/molecules25122898 Randomized trial
https://doi.org/10.3390/molecules25122898
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